Abstract
Serum concentrations of corticosterone were increased following activation of 5-HT1A receptors with 8-OH-DPAT or activation of 5-HT2 receptors with MK-212 or DOI. The repeated administration of a 5-HT1A agonist, 5-MeODMT, selectively diminished the corticosterone response to 8-OH-DPAT, whereas the repeated administration of a 5-HT2 agonist, DOI, selectively diminished the corticosterone response to MK-212. Serum concentrations of PRL were increased following the administration of a 5-HT2 agonist (viz., DOI) but not 5-HT1A agonists (viz., 8-OH-DPAT, ipsapirone, gepirone). It is concluded that corticosterone secretion can be enhanced through the activation of either 5-HT1A or 5-HT2 receptors. The role of subtypes, other than 5-HT2, in the stimulation of PRL secretion is less clear.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fuller, R.W. and Snoddy, H.D. (1984) ‘Central serotonin antagonist activity of ketanserin’, Res. Comm. Chem. Path. Pharmacol. 46, 151–154.
Koenig, J.I., Gudelsky, G.A. and Meltzer, H.Y. (1987) ‘Stimulation of corticosterone and β-endorphin secretion in the rat by selective 5-HT receptor subtype activation’, Eur. J. Pharmacol. 137, 1–8.
Koenig, J.I., Meltzer, H.Y. and Gudelsky, G.A. (1988), ‘5-Hydroxy- tryptamine1A receptor mediated effects of buspirone, gepi¬rone and ipsapirone’, Pharmacol. Biochem. Behav. 29, 711–715.
Meltzer, H.Y., Simonovic, M. and Gudelsky, G.A. (1983) ‘Effects of pirenperone and ketanserin in rat prolactin secretion in vivo and in vitro’, Eur. J. Pharmacol. 92, 83–89.
Meltzer, H.Y., Simonovic, M. and Gudelsky, G.A. (1983) ‘Effects of pirenperone and ketanserin in rat prolactin secretion in vivo and in vitro’, Eur. J. Pharmacol. 92, 83–89.
Meltzer, H.Y., Simonovic, M. and Gudelsky, G.A. (1983) ‘Effects of pirenperone and ketanserin in rat prolactin secretion in vivo and in vitro’, Eur. J. Pharmacol. 92, 83–89.
Rech, R.H. and Gudelsky, G.A. (1988), ‘5-HT Agonists on Psychoactive Drugs, NPP Books, Ann Arbor, MI.
Simonovic, M., Gudelsky, G.A. and Meltzer, H.Y. (1984) ‘Effect of 8-hydroxy-2- (di-n-propylamino) tetralin on rat prolactin secre¬tion’, J. Neural Transm. 59, 143–149.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Kluwer Academic Publishers
About this chapter
Cite this chapter
Gudelsky, G.A., Nash, J.F., Koenig, J.I., Meltzer, H.Y. (1990). Serotonin Agonist Induced Corticosterone and Prolactin Secretion: Role of 5-HT2 and 5-HT1A Receptors. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_76
Download citation
DOI: https://doi.org/10.1007/978-94-009-1912-9_76
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7353-0
Online ISBN: 978-94-009-1912-9
eBook Packages: Springer Book Archive