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Adenylate Cyclase-Linked 5-Hydroxytryptamine Receptors in the Brain

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Book cover Serotonin

Abstract

The 5-hydroxytryptamine (5-HT) receptors which mediate the stimulation and inhibition of adenylate cyclase (AC; EC 4.6.1.1) activity were the subject of a recent review [De Vivo, M. and Maayani, S. (1988) in E. Sanders-Bush (ed.). The Serotonin Receptors, Humana Press, Clifton, N.J., pp. 141–179]. Highlights of the previous review are reiterated here, with a more detailed discussion of developments from the middle of 1987 through the end of 1988. Recent progress has included: 1) the discovery of additional 5-HT receptor subtypes; 2) the cloning and sequencing of one receptor subtype (5-HT1A) that is linked both positively and negatively to AC; 3) the identification of additional guanine nucleotide-binding proteins, some of which couple the 5-HT receptors to AC, and 4) attempts to determine the relationship between the mitogenic effects of 5-HT and its effects on AC activity in certain cell types. The recent suggestion that the 5-HT1A receptor and the adenosine A1 receptor may share the same effector system(s) in the same cells of the rat hippocampus was based on the similar toxin sensitivity and the non-additivity of the effects of 5-HT1A-specific ligands and adenosine analogs on AC activity and ion channel conductance in these cells. Further research is needed to elucidate the molecular basis for the apparent differences in the responsiveness to 5-HT of AC in the same tissue in various physiological or pathological states or in different regions of the brain in which the receptors appear to be the same.

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Authors and Affiliations

  1. Department of Anesthesiology, Mount Sinai School of Medicine, City University of New York, New York, New York, 10029, USA

    Saul Maayani

  2. Department of Pharmacology, Mount Sinai School of Medicine, City University of New York, New York, New York, 10029, USA

    Saul Maayani

  3. Department of Biological Sciences, Rutgers University, Newark, New Jersey, 07102, USA

    Merry R. Sherman

  4. Department of Chemistry, Rutgers University, Newark, New Jersey, 07102, USA

    Merry R. Sherman

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  1. Fondazione Lorenzini, Milan, Italy

    Rodolfo Paoletti

  2. Mayo Clinic, Rochester, Minnesota, USA

    Paul M. Vanhoutte

  3. Institute of Pharmacological Sciences, University of Milan, Italy

    Nicoletta Brunello  & Franco M. Maggi  & 

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Maayani, S., Sherman, M.R. (1990). Adenylate Cyclase-Linked 5-Hydroxytryptamine Receptors in the Brain. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_7

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  • DOI: https://doi.org/10.1007/978-94-009-1912-9_7

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