Abstract
Subtypes of brain serotonin (5-HT) receptors mediate distinct electrophysiological effects via different effector mechanisms: 1) 5-HT1 receptors induce a slow hyperpolarization via pertussis toxin-sensitive G proteins coupled to the opening of K+ channels; 2) 5-HT2 receptors induce a slow depolarization, partly by a closing of K+ channels negatively modulated by a stimulation of phosphoinositide (PI) hydrolysis; 3) 5-HT3 receptors induce a response distinct from the others, a fast, rapidly desensitizing excitation.
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Aghajanian, G.K., Sprouse, J.S., Sheldon, P., Rasmussen, K. (1990). Electrophysiology of Brain Serotonin Receptors: Subtype Specificity for Effector Mechanisms. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_35
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