Skip to main content
SpringerLink
Log in
Book cover

Serotonin pp 193–202Cite as

Serotonin Transmission and Food Intake

  • Chapter

Abstract

Serotonin (5HT) injected into the rat paraventricular nucleus (PVN) of the hypothalamus reduces food intake and antagonizes the hyperphagia induced by noradrenaline administered in the same area (1). This effect is particularly evident on carbohydrate intake when 5HT is administered early in the night (2). 5HT also has anorectic activity when given by a general route (3) but in this case it acts peripherally since it does not cross the blood-brain barrier.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Leibowitz, S.F., Weiss, G.F. and Shor-Posner, G. (1988) Hypothalamic serotonin: Pharmacological, biochemical, and behavioral analyses of its feeding-suppressive action. Clin. Neuropharmacol. 11, Suppl. 1, S51–S71.

    Google Scholar 

  2. Weiss, G. F. and Leibowitz, S.F. (1988) The impact of serotonergic agonists on nocturnal patterns of macronutrient selection. In Society for Neuroscience Abstracts V.14, part 1, 613.

    Google Scholar 

  3. Fletcher, P. J. and Burton, M.J. (1984) Effects of manipulations of peripheral serotonin on feeding and drinking in the rat. Pharmacol. Biochem. Behav. 20, 835–840.

    Google Scholar 

  4. Angel, I., Taranger, M. A., Claustre,Y., Scatton, B. and Langer, S. Z. Anorectic activities of serotonin uptake inhibitors: Correlation with their potencies at inhibiting serotonin uptake in vivo and 3H-mazindol binding in vitro. Life Sci., In Press.

    Google Scholar 

  5. Samanin, R., Caccia, S., Bendotti, C., Borsini, F., Borroni, E., Invernizzi, R., Pataccini, R. and T. Mennini (1980) Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology 68, 99–104.

    Article  PubMed  CAS  Google Scholar 

  6. Samanin, R., Caccia, S., Bendotti, C., Borsini, F., Borroni, E., Invernizzi, R., Pataccini, R. and T. Mennini (1980) Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology 68, 99–104.

    Article  PubMed  CAS  Google Scholar 

  7. Wong,D.T., Reid, L.R. and Threlkeld, P.G. (1988) Suppression of food intake in rats by fluoxetine: Comparison of enantiomers and effects of serotonin antagonists. Pharmacol. Biochem. Behav. 31, 475–479.

    Google Scholar 

  8. Borsini, F., Bendotti, C., Aleotti, A., Samanin, R. and Garattini, S. (1982) d-Fenfluramine and d-norfenfluramine reduce food intake by acting on different serotonin mechanisms in the rat brain. Pharmacol. Res. Commun. 14, 671–678.

    Google Scholar 

  9. Lucki, I., Kreider, M. S. and Simansky, K. J. (1988) Reduction of feeding behavior by the serotonin uptake inhibitor sertraline. Psychopharmacology 96, 289–295.

    Article  PubMed  CAS  Google Scholar 

  10. Samanin, R., Mennini, T., Ferraris, A., Bendotti, C., Borsini, F. and Garattini, S. (1979) m-Chlorophenylpiperazine: A central serotonin agonist causing powerful anorexia in rats. Naunyn-Schmiedeberg’s Arch. Pharmacol. 308, 159–163.

    Google Scholar 

  11. Samanin, R., Bendotti, C., Candelaresi, G. and Garattini, S. (1977). Specificity of serotoninergic involvement in the decrease of food intake induced by quipazine in the rat. Life Sci. 21, 1259–1266.

    Article  PubMed  CAS  Google Scholar 

  12. Bendotti, C. and Samanin, R. (1987) The role of putative 5-HT1A and 5-HT1B receptors in the control of feeding in rats. Life Sci. 41, 635–642.

    Article  PubMed  CAS  Google Scholar 

  13. Garattini, S., Bizzi, A., Caccia, S., Mennini, T. and Samanin, R. (1988) Progress in assessing the role of serotonin in the control of food intake. Clin. Neuropharmacol. 11, suppl., S8–S32.

    Google Scholar 

  14. Samanin, R. Serotonin and feeding, in Behavioral Pharmacology of 5-HT. T. Archer, P. Bevan and L. Cools (eds.) Lawrence Erlbaum, Hillsdale, In Press.

    Google Scholar 

  15. Garattini, S., Mennini, T. and Samanin, R. (1987) From fenfluramine racemate to d-fenfluramine: Specificity and potency of the effects on the serotoninergic system and food intake. Ann. NY Acad. Sci. 409, 156–166.

    Google Scholar 

  16. Samanin, R. (1983) Drugs affecting serotonin and feeding, in Biochemical Pharmacology of Obesity. P.B. Curtis-Prior (ed.) Elsevier, Amsterdam, pp. 339–356.

    Google Scholar 

  17. Blundell, J. E. (1984) Serotonin and appetite. Neuropharmacology 23, 1537–1551.

    Article  PubMed  CAS  Google Scholar 

  18. Bendotti, C. and Samanin, R. (1986) 8-Hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) elicits eating in free-feeding rats by acting on central serotonin neurons. Eur. J. Pharmacol. 121, 147–150.

    Google Scholar 

  19. Hutson, P. H., Dourish, C. T. and Curzon, G. (1986) Neurochemical and behavioural evidence for mediation of the hyperphagic action of 8-OH-DPAT by 5-HT cell body autoreceptors. Eur. J. Pharmacol. 129, 347–352.

    Google Scholar 

  20. Kennett, G. A., Dourish, C. T. and Curzon, G. (1987) 5–HT1B agonists induce anorexia at a postsynaptic site. Eur. J. Pharmacol. 141, 429–435.

    Google Scholar 

  21. Dourish, C. T. and Gilbert, F.(1987) Interactions between 5-HT1A agonists on food intake in rats. Br. J. Pharmacol. 91,425P

    Google Scholar 

  22. Wong, D. T. and Reid, L. R. (1987) Fenfluramine antagonizes the stimulation of food intake induced by the putative 5-hydroxytryptamine1A agonist, isapirone, in Non-fasted rats. J. Pharm. Pharmacol. 39, 570–571.

    Google Scholar 

  23. Mennini, T., Gobbi, M., Taddei, C. and Garattini, S. (1988) Characterization of high affinity and stereospecific [3H]d-fenfluramine binding to rat brain. Neurochem. Int. 13, 345–351.

    Google Scholar 

  24. Briley, M. and Langer, S.Z. (1981): Sodium dependency of [3H]imipramine binding in rat brain cerebral cortex. Eur. J. Pharmacol., 72, 377–380.

    Google Scholar 

  25. Gobbi, M., Taddei, C. and Mennini, T. (1988) Different components of 3H-imipramine binding in rat brain membranes: Relation to serotonin uptake sites. Life Sci. 42, 575–583.

    Article  PubMed  CAS  Google Scholar 

  26. Garattini, S., Menini, T., Samanin, R. (1987) Advances in understanding the role of serotonin in controlling food intake, in E.M. Berry, S.H. Blondheim, H.E. Eliahou and E. Shafrir (eds.), Recent Advances in Obesity Research: V, John Libbey, London, pp. 272–284.

    Google Scholar 

  27. Ghezzi, D., Samanin, R., Bernasconi, S., Tognoni, G., Gerna, M. and Garattini, S. (1973) Effect of thymoleptics on fenfluramine-induced depletion of brain serotonin in rats. Eur. J. Pharmacol. 24, 205–210.

    Google Scholar 

  28. Fuller, R.W., Snoddy, H.D. and Hemrick, S.K. (1978) Effects of fenfluramine and norfenfluramine on brain serotonin metabolism in rats. Proc. Soc. Exp. Biol. Med., 157, 202–205.

    Google Scholar 

  29. Fuller, R.W., Snoddy, H.D. and Hemrick, S.K. (1978) Effects of fenfluramine and norfenfluramine on brain serotonin metabolism in rats. Proc. Soc. Exp. Biol. Med., 157, 202–205.

    Google Scholar 

  30. Invernizzi, R., Fracasso, C., Caccia, S., Di Clemente, A., Garattini, S. and Samanin, R. (1989) Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. Eur. J. Pharmacol. 163, 77–83.

    Google Scholar 

  31. Invernizzi, R., Fracasso, C., Caccia, S., Di Clemente, A., Garattini, S. and Samanin, R. (1989) Effect of L-cysteine on the long-term depletion of brain indoles caused by p-chloroamphetamine and d-fenfluramine in rats. Relation to brain drug concentrations. Eur. J. Pharmacol. 163, 77–83.

    Google Scholar 

  32. Samanin, R., Bendotti, C., Miranda, F. and Garattini, S. (1977) Decrease of food intake by quipazine in the rat: Relation to serotoninergic receptor stimulation. J. Pharm. Pharmacol. 29, 53–54.

    Article  PubMed  CAS  Google Scholar 

  33. Garattini, S., Buczko, W., Jori, A. and Samanin, R. (1975) The mechanism of action of fenfluramine. Postgrad. Med. J. 51 Suppl. 1., 27–35.

    Google Scholar 

  34. Garattini, S., Mennini, T., Bendotti, C., Invernizzi, R. and R. Samanin, R. (1986) Neurochemical mechanism of action of drugs which modify feeding via the serotoninergic system. Appetite 7, Suppl., 15–38.

    Google Scholar 

  35. Miranda, G.F., Poggesi, E., Bianchetti, A., Unkovic, J. and Samanin, R. (1988) Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. Eur. J. Pharmacol. 150, 155–161.

    Google Scholar 

  36. Simpson, R.J., Lawton, D.J., Watt, M.H., and Tiplady, B. (1981): Effect of zimelidine, a new antidepressant, on appetite and body weight. Br. J. Clin. Pharmacol. 11, 96–98.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Ricerche Farmacologiche “Mario Negri”, Via Eritrea, 62, 20157, Milan, Italy

    S. Garattini, S. Caccia, T. Mennini & R. Samanin

Authors
  1. S. Garattini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Caccia
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Mennini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Samanin
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Fondazione Lorenzini, Milan, Italy

    Rodolfo Paoletti

  2. Mayo Clinic, Rochester, Minnesota, USA

    Paul M. Vanhoutte

  3. Institute of Pharmacological Sciences, University of Milan, Italy

    Nicoletta Brunello  & Franco M. Maggi  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Garattini, S., Caccia, S., Mennini, T., Samanin, R. (1990). Serotonin Transmission and Food Intake. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1912-9_25

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7353-0

  • Online ISBN: 978-94-009-1912-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation