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Serotonin Receptors Regulating Transmitter Release

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Book cover Serotonin

Abstract

The effects of serotonin (5-HT) and of various serotonergic agents on the release of 3H-acetylcholine (3H-ACh) and of endogenous glutamate (GLU) have been studied in rat hippocampal and cerebellar synaptosomes and slices depolarized with KCl or stimulated electrically. The results allow to conclude that: a) hippocampal cholinergic terminals are endowed with a tonically activated inhibitory 5-HT receptor which appears to belong to the 5-HT1B subtype; b) cerebellar GLU release appears to be tonically inhibited by 5-HT through the activation of both 5-HT1 and 5-HT2 receptors. The 5-HT1 receptors are located on GLU terminals (parallel fibers); they do not conform to the criteria defining the known 5-HT binding sites and might therefore represent a novel subtype of the 5-HT2 receptor. The possible localization of the 5-HT receptors is discussed.

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Authors and Affiliations

  1. Institute of Pharmacology and Pharmacognosy, University of Genoa, Viale Cembrano 4, 16148, Genoa, Italy

    M. Raiteri, G. Maura, G. Bonanno, A. Pittaluga, E. Fedele, C. Costa, M. G. Cerasoli & M. Ulivi

Authors
  1. M. Raiteri
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  2. G. Maura
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  3. G. Bonanno
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  4. A. Pittaluga
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  5. E. Fedele
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  6. C. Costa
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  7. M. G. Cerasoli
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  8. M. Ulivi
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Editor information

Editors and Affiliations

  1. Fondazione Lorenzini, Milan, Italy

    Rodolfo Paoletti

  2. Mayo Clinic, Rochester, Minnesota, USA

    Paul M. Vanhoutte

  3. Institute of Pharmacological Sciences, University of Milan, Italy

    Nicoletta Brunello  & Franco M. Maggi  & 

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© 1990 Kluwer Academic Publishers

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Raiteri, M. et al. (1990). Serotonin Receptors Regulating Transmitter Release. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_22

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  • DOI: https://doi.org/10.1007/978-94-009-1912-9_22

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7353-0

  • Online ISBN: 978-94-009-1912-9

  • eBook Packages: Springer Book Archive

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