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Serotonergic Regulation of Renin and Vasopressin Secretion

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Serotonin

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Abstract

This chapter reviews the evidence that a serotonergic (5-HT containing) pathway (dorsal raphe to the hypothalamus) stimulates renin secretion by activation of 5-HT2 receptors. Serotonergic nerve terminals in the hypothalamus stimulate the secretion of a renin releasing factor (RRF) into the blood stream, which then stimulates renin secretion from the kidneys. Denervation of serotonergic neurons with 5,7-dihydroxytryptamine (5,7-DHT) produces up-regulation of the 5-HT2 receptors, resulting in a left-ward shift in the dose-response effect of the 5-HT agonist RU 24969 on renin secretion. The evidence for serotonergic stimulation of vasopressin (AVP) secretion is less abundant, but suggests that 5-HT nerve terminals in the hypothalamus stimulate AVP secretion by activating 5-HT2 receptors. Serotonergic neurons mediate the hyperosmotic stimulation of AVP secretion.

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Author information

Authors and Affiliations

  1. Department of Pharmacology Stritch School of Medicine, Loyola University of Chicago, 2160 S. First Avenue, Maywood, Illinois, 60153, USA

    Louis D. Van de Kar & Janice H. Urban

  2. University of Wisconsin, Madison, WI, USA

    Mark S Brownfield

Authors
  1. Louis D. Van de Kar
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  2. Janice H. Urban
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  3. Mark S Brownfield
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Editor information

Editors and Affiliations

  1. Fondazione Lorenzini, Milan, Italy

    Rodolfo Paoletti

  2. Mayo Clinic, Rochester, Minnesota, USA

    Paul M. Vanhoutte

  3. Institute of Pharmacological Sciences, University of Milan, Italy

    Nicoletta Brunello  & Franco M. Maggi  & 

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© 1990 Kluwer Academic Publishers

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Van de Kar, L.D., Urban, J.H., Brownfield, M.S. (1990). Serotonergic Regulation of Renin and Vasopressin Secretion. In: Paoletti, R., Vanhoutte, P.M., Brunello, N., Maggi, F.M. (eds) Serotonin. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1912-9_16

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  • DOI: https://doi.org/10.1007/978-94-009-1912-9_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7353-0

  • Online ISBN: 978-94-009-1912-9

  • eBook Packages: Springer Book Archive

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