Abstract
Like most drug development programmes cancer chemotherapy covers three broad areas, screening, analogue synthesis and rational drug design. The aim of large scale empirical screening is to discover ‘lead’ compounds which will form the basis for analogue synthesis. Analogues of the ‘lead’ chemical are evaluated in the hope that some will be more clinically useful because they are more selective (i.e. have fewer side effects at the effective dose) or for instance maintain their activity when given orally. Once some information has been obtained on how the drug works it may then be possible to design new types of agent which may have superior qualities (referred to as rational design).
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© 1990 Kluwer Academic Publishers, Dordrecht
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Connors, T.A. (1990). The use of animals in cancer chemotherapy. In: Garattini, S., van Bekkum, D.W. (eds) The Importance of Animal Experimentation for Safety and Biomedical Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1904-4_15
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DOI: https://doi.org/10.1007/978-94-009-1904-4_15
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7349-3
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