Skip to main content
SpringerLink
Log in

Spontaneous gamma-interferon production by human tonsillar lymphocytes: regulation of secretion by interleukin-1

  • Chapter
Advances in Mucosal Immunology

  • 21 Accesses

Abstract

The frequency of gamma-interferon (IFN-γ) secreting cells was examined in tonsillar cell suspensions. Comparisons were made between tonsils from orally and/or parenterally immunized individuals and non-immunized controls, and between infected and clinically healthy tonsils. Our results show that the tonsils are the site of pronounced T-lymphocyte (and possibly natural killer cell) activation, irrespective of intentional immunization or clinical status. In addition, this study suggests that interleukin-1 is required not only as an inducer of IFN-γ synthesis, but also as a promoter of its secretion. (Supported by the Swedish Medical Research Council).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 429.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 549.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Holmgren J., Svennerholm A.-M., Lönnroth I., et al (1977) Nature (London) 269, 602

    Article  Google Scholar 

  2. Czerkinsky C., Andersson G., Ekre H-P. et al (1988) J. Immunol. Methods, 110, 29

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Microbiology, University of Göteborg, Sweden

    M Quiding, I Nordström, G Granström, J Holmgren & C Czerkinsky

  2. Department of Clinical Immunology and Medicine, University of Göteborg, Sweden

    M Quiding, I Nordström, G Granström, J Holmgren & C Czerkinsky

Authors
  1. M Quiding
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I Nordström
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Granström
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Holmgren
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Czerkinsky
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK

    Thomas T MacDonald PhD MRCPath (Wellcome Senior Lecturer) (Wellcome Senior Lecturer)

  2. Department of Oral Medicine and Pathology, Guy’s Hospital, London, UK

    Stephen J Challacombe PhD BDS MRCPath (Professor) (Professor)

  3. Department of Veterinary Medicine, The University, Bristol, UK

    Paul W Bland PhD (Lecturer) & Christopher R Stokes PhD (Senior Research Fellow) (Lecturer) &  (Senior Research Fellow)

  4. Department of Medicine, St James’s University Hospital, London, UK

    Richard V Heatley MD MRCP (Senior Lecturer) (Senior Lecturer)

  5. Department of Bacteriology and Immunology, The University, Glasgow, UK

    Allan Mcl Mowat PhD MB ChB (Lecturer) (Lecturer)

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Kluwer Academic Publishers

About this chapter

Cite this chapter

Quiding, M., Nordström, I., Granström, G., Holmgren, J., Czerkinsky, C. (1990). Spontaneous gamma-interferon production by human tonsillar lymphocytes: regulation of secretion by interleukin-1. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_41

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1848-1_41

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7323-3

  • Online ISBN: 978-94-009-1848-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation