Human interleukin-5 “switches” human IgA+ B cells to express and secrete IgA

Bertolini, J N; Benson, E M

doi:10.1007/978-94-009-1848-1_35

J N Bertolini⁶ &
E M Benson⁶

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Abstract

In the murine and the human system there is evidence that T-cells regulate both isotype switching to IgA (1,2), and post-switch expansion of IgA⁺ B-cells (2,3). The post-switch activity in the murine system appears to be mediated, at least in part, by Interleukin-5 (IL-5) (4). However, experiments examining the role of human IL-5 in IgA secretion failed to validate the results in the mouse (5).

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Department of Pathology and Immunology and Medicine, Monash University Medical School, Alfred Hospital, Commercial Road, Prahran, 3181, Victoria, Australia
J N Bertolini & E M Benson

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J N Bertolini
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E M Benson
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Editors and Affiliations

Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK
Thomas T MacDonald PhD MRCPath (Wellcome Senior Lecturer) (Wellcome Senior Lecturer)
Department of Oral Medicine and Pathology, Guy’s Hospital, London, UK
Stephen J Challacombe PhD BDS MRCPath (Professor) (Professor)
Department of Veterinary Medicine, The University, Bristol, UK
Paul W Bland PhD (Lecturer) & Christopher R Stokes PhD (Senior Research Fellow) (Lecturer) & (Senior Research Fellow)
Department of Medicine, St James’s University Hospital, London, UK
Richard V Heatley MD MRCP (Senior Lecturer) (Senior Lecturer)
Department of Bacteriology and Immunology, The University, Glasgow, UK
Allan Mcl Mowat PhD MB ChB (Lecturer) (Lecturer)

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Bertolini, J.N., Benson, E.M. (1990). Human interleukin-5 “switches” human IgA+ B cells to express and secrete IgA. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_35

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DOI: https://doi.org/10.1007/978-94-009-1848-1_35
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7323-3
Online ISBN: 978-94-009-1848-1
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