Abstract
Previous work from this laboratory has shown that activated surface IgA-bearing (sIgA+) B cells of mice develop into IgA-secreting plasma cells under the influence of IL-5 and IL-6. We have examined the regulation of the IgA response by analysis of messenger RNA (mRNA) in murine intestinal cells. T cell hybridomas isolated from Peyer’s patch which have receptors for the Fc region of immunoglobulin α chain (FcαR) spontaneously secrete IL-5. The expression of mRNA for IL-5 in these cells is suppressed by incubation with IgA. Furthermore, we have found that intraepithelial lymphocytes of BALB/c mice also express mRNA for IL-5 in relatively high amounts compared to spleen cells. These results highlight unique features of intestinal cytokine production and may indicate the presence of a homeostatic mechanism whereby IL-5 synthesis by T cells in the intestine can be down-regulated by IgA via Fc receptors.
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References
Mosmann, T.R., Cherwinski, H., Bond, M.W., Geidlin, M.A. and Coffman, R.L. (1986) Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins’, J. Immunol. 136, 2348.
Kiyono, H., Cooper, M.D., Kearney, J.F., Mosteller, L.M., Michalek, S.M., Koopman, W.J. and McGhee, J.R. (1984) ‘Isotype-specificity of helper T cell clones. Peyer’s patch Th cells preferentially collaborate with membrane IgA B cells for IgA responses’, J. Exp. Med. 154: 798.
Roman, S., Moore, J.S., Darby, C., Müller, S. and Hoover, R.G. (1988) ‘Modulation of Ig gene expression by Ig binding factors. Suppression of αH-chain and λ2L chain mRNA accumulation in MOPC 315 by IgA-binding factor’, J. Immunol. 140: 3622.
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© 1990 Kluwer Academic Publishers
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Aicher, W.K., Beagley, K.W., Bruce, M.G., Kiyono, H., McGhee, J.R. (1990). Regulaton of intestinal immunity by soluble B and T cell products. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_32
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DOI: https://doi.org/10.1007/978-94-009-1848-1_32
Publisher Name: Springer, Dordrecht
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