Abstract
It is now widely recognized that local immune reactions mediated by activated gut associated lymphoid tissue (GALT) increase crypt depth, crypt cell production rate and intraepithelial lymphocyte numbers (Mowat & Ferguson, 1982). Secondary selective changes affecting enterocyte development also take place (Lund et al., 1986; Phillips et al., 1988). Mechanisms controlling the primary cause of these events, involving transport of enteric antigens across M cells in the FAE for presentation to the GALT, have been less well defined. Present work uses a new cytochemical technique (Smith et al., 1987; 1988) to quantify Salmonella effects on M cells present in germ-free mouse FAE.
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References
Bye, W.A., Allan, C.H. and Trier, J.S. (1984) ‘Structure, distribution and origin of M cells in Peyer’s patches of mouse ileum’, Gastroenterology, 86, 789–801.
Collins, F.M. and Carter, P.B. (1978) ‘Growth of Salmonellae in orally infected germ free mice’, Infect. Immunol. 21, 41–47.
Dougan, G., Hormaeche, C.E. and Maskell, D.J. (1987) ‘Live oral Salmonella vaccines: potential use of attenuated strains as carriers of heterologous antigens to the immune system’, Parasite Immunol. 9, 151–160.
Kohbata, S., Yokoyama, H. and Yabuuchi, E. (1986) ‘Cytopathogenic effect of Salmonella typhi GIFU 10007 on M cells of murine ileal Peyer’s patches in ligated ileal loops: an ultrastructural study’, Microbiol. Immunol. 30, 1225–1237.
Lund, E.K., Bruce, M.G., Smith, M.W. and Ferguson, A. (1986) ‘Selective effects of graft-versus-host reaction on disaccharidase expression by mouse jejunal enterocytes’, Clin. Sci. 71, 189–198.
Mowat, A. Mcl. and Ferguson, A. (1982) ‘Intraepithelial lymphocyte count and crypt hyperplasia measure the mucosal component of the graft-versus-host reaction in mouse small intestine’, Gastroenterology, 83, 417–423.
Phillips, A.D., Smith, M.W. and Walker-Smith, J.A. (1988) ‘Selective alteration of brush-border hydrolases in intestinal diseases in childhood’, Clin. Sci. 74, 193–200.
Smith, M.W. and Peacock, M.A. (1980) ‘“M” cell distribution in follicle-associated epithelium of mouse Peyer’s patch’, Am. J. Anat. 159, 167–175.
Smith, M.W., James, P.S. and Tivey, D.R. (1987) ‘M cell numbers increase after transfer of SPF mice to a normal animal house environment’, Am. J. Path. 128, 385–389.
Smith, M.W., James, P.S., Tivey, D.R. and Brown, D., (1988) ‘Automated histochemical analysis of cell populations in the intact follicle-associated epithelium of the mouse Peyer’s patch’, Histochem. J. 20, 443–448.
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© 1990 Kluwer Academic Publishers
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Savidge, T.C., Smith, M.W., James, P.S., Aldrid, P. (1990). Salmonella increases M cell numbers in mouse Peyer’s patch follicle associated epithelium. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_25
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DOI: https://doi.org/10.1007/978-94-009-1848-1_25
Publisher Name: Springer, Dordrecht
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