Abstract
The proximal colon of the rodent contains an organized lymphoid nodule consistently located 25% of the distance from the cecum to the anus. We have undertaken a morphokinetic evaluation of crypts associated with this lymphoid tissue, as compared to crypts on adjacent plicae. Results demonstrated that the crypts associated with this lymphoid nodule are deeper, contain greater numbers of columnar and goblet cells and have a greater cell production than crypts of adjacent alymphoid plicae. The distribution of metaphases is shifted toward the upper part of lymphoid associated crypts and the binding of radiolabelled recombinant human urogastrone (rhUG/EGF) is greater even in mice treated with steroid to deplete the lymphoid elements. These results indicate a significant lymphoepithelial interaction associated with proximal colonic lymphoid tissue (PCLT), and suggest that this interaction may be mediated by a locally acting paracrine mechanism(s).
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References
Brandtzaeg, P., Baklien, K., Bjerke, K., Tognum, T.O., Scott, H. and Valnes, K. (1987) ‘Nature and properties of the human gastrointestinal immune system, In Miller, K. and Nicklin, S. (Eds.) Immunology of the Gastrointestinal Tract, CRC Press, Boca Raton, pp. 1–85.
Perry, G.A. and Sharp, J.G. (1988) ‘Characterization of proximal colonic lymphoid tissue in the mouse.’ Anat. Rec. 220, 305–312.
Crouse, DA., Perry, G.A., Murphy, B.O. and Sharp, J.G. (1989) ‘Characteristics of submucosal lymphoid tissue located in the proximal colon of the rat.’ J. Anat. 162, 53–65.
Langman, J.M. and Rowland, R. (1986) ‘The number and distribution of lymphoid follicles in the human large intestine’ J. Anat. 194, 189–194.
Perry, G.A. and Eccleston-Joyner, C. (1989) ‘Ultrastructural characterization of proximal colonic lymphoid tissue in the mouse.’ This Volume.
Hunter, W.M. and Greenwood, F.C. (1962) ‘Preparation of Iodine-131 labelled human growth hormone of high specific activity.’ Nature 194, 495–496.
McGarrity, TJ., Peiffer, L.P. and Colony, P.C. (1988) ‘Cellular proliferation in proximal and distal rat colon during 1,2 - dimethylhydrazine-induced carcinogenesis.’ Gastroent. 95, 343–348.
Deschner, E.E., Goldbold, J. and Lynch, H.T. (1988) ‘Rectal epithelial cell proliferation in a group of young adults: Influence of age and genetic risk for colon cancer.’ Cancer 61, 2286–2290.
Sharp, J.G. and Crouse, D.A. (1989) ‘Apparent synergism between radiation and the carcinogen 1,2- dimethylhydrazine in the induction of colonic tumors in rats.’ Radiat. Res. 117, 304–317.
Maunda, K.K.Y. and Moore, J.V. (1987) ‘Radiobiology and stathmokinetics of intestinal crypts associated with patches of Peyer.’ Int. J. Radiat Biol 51, 255–264.
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© 1990 Kluwer Academic Publishers
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Saxena, S.K., Perry, G.A., Joshi, S.S., Sharp, J.G. (1990). Lymphoepithelial interactions associated with proximal colonic lymphoid tissue in the mouse. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_24
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DOI: https://doi.org/10.1007/978-94-009-1848-1_24
Publisher Name: Springer, Dordrecht
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