Abstract
Intraepithelial lymphocytes form one of the largest populations of T lymphocytes in the body and probably play an important role in both immune defence and in immunopathology in the intestine. Nevertheless, their functions are unclear, partly because they have an unusual phenotype, with a large proportion of CD8+ T cells, many of which do not express pan T cell markers such as Thy1 or CD5 (1).
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Parrott, D.M.V., Tait, C., MacKenzie, S., Mowat, A.Mcl., Davies, M. D.J. and Micklem, H.S. (1983)’Analysis of the effector functions of different populations of mucosal lymphocytes1, Ann. N.Y. Acad. Sei 409, 307–20
Goodman, T. and Lefrancois, L. (1988) ’Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes, Nature 333, 855–8.
Bonneville, M., Janeway, C.A., Ito, K., Haser, W., Ishida, I., Nakanishi, N. and Tonegawa, S. (1988) Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells, Nature 336, 479–81.
Davies, M.D.J, and Parrott, D.M.V. (1981) Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine, Gut 22, 481–8.
Viney, J.L., MacDonald, T.T. and Kilshaw, P.J. (1989) “T cell receptor expression in intestinal intraepithelial lymphocyte sub- populations of normal and athymic mice”, Immunology 66, 583–7.
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© 1990 Kluwer Academic Publishers
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Mowat, A.M., Edwards, A.J., Crispe, I.N. (1990). T cell receptor expression by CD8+ intraepithelial lymphocytes from mouse small intestine. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_21
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DOI: https://doi.org/10.1007/978-94-009-1848-1_21
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