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Advances in Mucosal Immunology pp 67–68Cite as

The gamma/delta T cell receptor (TCR) is expressed on less than 50% of intraepithelial lymphocytes (IEL) in human intestine

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Abstract

The γ/δ T cell receptor (TCR) is found on virtually all intestinal intraepithelial cells (IEL) and on dendritic cells of the epidermis in the murine system but only on a small proportion of peripheral blood lymphocytes (PBL) or in other lymphoid organs; thus a specific function of γ/δ T cells at epithelial surfaces has been discussed [1]. Very limited data exists so far on the distribution and phenotypic characteristics of γ/δ T cells in the human intestine. Therefore, we studied the expression of the γ/δ TCR and the coexpression with other surface antigens on human intestinal IEL.

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References

  1. Janeway, C.A., Jones, B., and Hayday, A. (1988) ‘Specifity and function of T cells bearing γ/δ receptors’, Immunol. Today, 9, 73–6

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  2. Cerf-Bensussan, N., Jarry, A., Brousse, N., Liskowska-Grospierre, B., Guy-Grand, D., and Griscelli, C. (1987) ‘A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes’, Eur. J. Immunol., 17, 1279–85

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Authors and Affiliations

  1. Medical Department, Klinikum Steglitz, Free University of Berlin, Hindenburgdamm 30, 1000, Berlin 45, West Germany

    R Ullrich, H Schieferdecker, C Brunn, E O Riecken & M Zeitz

Authors
  1. R Ullrich
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  2. H Schieferdecker
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  3. C Brunn
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  4. E O Riecken
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  5. M Zeitz
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Editor information

Editors and Affiliations

  1. Department of Paediatric Gastroenterology, St Bartholomews Hospital, London, UK

    Thomas T MacDonald PhD MRCPath (Wellcome Senior Lecturer) (Wellcome Senior Lecturer)

  2. Department of Oral Medicine and Pathology, Guy’s Hospital, London, UK

    Stephen J Challacombe PhD BDS MRCPath (Professor) (Professor)

  3. Department of Veterinary Medicine, The University, Bristol, UK

    Paul W Bland PhD (Lecturer) & Christopher R Stokes PhD (Senior Research Fellow) (Lecturer) &  (Senior Research Fellow)

  4. Department of Medicine, St James’s University Hospital, London, UK

    Richard V Heatley MD MRCP (Senior Lecturer) (Senior Lecturer)

  5. Department of Bacteriology and Immunology, The University, Glasgow, UK

    Allan Mcl Mowat PhD MB ChB (Lecturer) (Lecturer)

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© 1990 Kluwer Academic Publishers

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Ullrich, R., Schieferdecker, H., Brunn, C., Riecken, E.O., Zeitz, M. (1990). The gamma/delta T cell receptor (TCR) is expressed on less than 50% of intraepithelial lymphocytes (IEL) in human intestine. In: MacDonald, T.T., Challacombe, S.J., Bland, P.W., Stokes, C.R., Heatley, R.V., Mowat, A.M. (eds) Advances in Mucosal Immunology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1848-1_16

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  • DOI: https://doi.org/10.1007/978-94-009-1848-1_16

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7323-3

  • Online ISBN: 978-94-009-1848-1

  • eBook Packages: Springer Book Archive

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