Abstract
An almost universal property of bacteria in nature and disease is the possession of an extracellular polysaccharide-containing structure (glycocalyx) which is more or less firmly associated with the outer membrane of Gram-negative cells and the peptidoglycan of Gram-positive cells (Costerton et al., 1981). Within the genus Pseudomonas the major component of the glycocalyx is the exopolysaccharide alginate which is partially O-acetylated on the mannuronate residues (see Chapter 3). Several functions of P. aeruginosa alginate have been proposed, including mediation of bacterial adherence to tracheobronchial mucins of lung tissue (see Chapter 6), promotion of microcolony formation (see Chapter 5), defence against the host immune system (see Chapters 7 and 8), and protection from lung surfactants and certain antibiotics (see Chapters 4 and 8). Because it has these functions alginate is considered an important virulence factor of mucoid P. aeruginosa in chronic pulmonary colonization of CF patients (Govan and Harris, 1986).
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Wingender, J. (1990). Interactions of alginate with exoenzymes. In: Gacesa, P., Russell, N.J. (eds) Pseudomonas Infection and Alginates. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1836-8_9
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DOI: https://doi.org/10.1007/978-94-009-1836-8_9
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