Abstract
The principle that colonization of tissue surfaces precedes an active infection is widely accepted. Interference with colonization would presumably prevent or reduce the incidence of infection. Thus numerous studies have been designed to identify the mechanisms of adherence of organisms to cells. These studies have centred primarily on defining the bacterial adhesins and the cellular receptors with which the adhesins interact. Clearly the best-studied adhesins have been bacterial pili, particularly those of Escherichia coli. Detailed information about pili structures and the specific receptors are available. The Pap pili of uropathogenic E. coli is the most extensively studied system (for review see Normark et al., 1986). A binding subunit of the pilus structure has been localized to the tip of the pilus and the receptor has been identified as an α-D-galactose (1 → 4) (ß-D-galactose-containing oligosaccharide (Leffler and Svanborg-Eden, 1981; Bock et al., 1985).
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Baker, N.R. (1990). Adherence and the role of alginate. In: Gacesa, P., Russell, N.J. (eds) Pseudomonas Infection and Alginates. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1836-8_6
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DOI: https://doi.org/10.1007/978-94-009-1836-8_6
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