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Enzymes as targets for drug design

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Enzyme Chemistry

Abstract

Alfred Burger (1980) dates the modern era of medicinal chemistry from the discovery of the antibacterial properties of sulphanilamide in 1936. The subsequent observation that sulphanilamide antagonized the incorporation of p-aminobenzoic acid into folic acid marked the beginning of a shift in the medicinal chemist’s attention from endogenous metabolites per se to the biochemical processes which control the flux of these metabolites in the organism. Many of these important biochemical processes are the enzyme- catalysed reactions of biosynthesis and catabolism. Most others are receptor-mediated processes in which interaction of an endogenous ligand with a receptor in a cell membrane initiates a complex sequence of biochemical events. The research topics in our own organization’s portfolio of projects appear to be based almost equally on receptor and enzyme mechanisms. This balance is unlikely to be greatly different elsewhere.

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Authors
  1. Philip D. Edwards
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  2. Barrie Hesp
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  3. D. Amy Trainor
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  4. Alvin K. Willard
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Editors and Affiliations

  1. Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

    Colin J. Suckling (Professor of Organic Chemistry) (Professor of Organic Chemistry)

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Edwards, P.D., Hesp, B., Trainor, D.A., Willard, A.K. (1990). Enzymes as targets for drug design. In: Suckling, C.J. (eds) Enzyme Chemistry. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1832-0_5

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