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Helicobacter pylori and the gastric environment

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Helicobacter pylori

Abstract

The presence of acid secretion in the stomach was thought for many years not only to aid digestion but also to act as a barrier to bacterial infection. The isolation of Helicobacter pylori in the stomach has refuted this idea, at least in part1,2. The now-proven association of infection with this organism and the presence of duodenal and gastric ulcer disease has made eradication of H. pylori a central issue in the treatment of acid-related diseases3,4. The induction of gastritis by the organism, and the tendency towards atrophic gastritis with inflammation, points to an association of H. pylori infection and gastric cancer. Furthermore, the treatment of reflux disease with proton pump inhibitor drugs appears to accelerate atrophic gastritis in the body of the stomach of H. prylori-positive individuals4,5.

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Authors
  1. G. Sachs
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  2. K. Meyer-Rosberg
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  3. D. R. Scott
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  4. K. Melchers
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Sachs, G., Meyer-Rosberg, K., Scott, D.R., Melchers, K. (1996). Helicobacter pylori and the gastric environment. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_6

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

  • eBook Packages: Springer Book Archive

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