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The problem ulcer: bleeding, perforation, Helicobacter pylori-negativity and intractability

  • M. Buckley
  • J. Lee
  • C. O’Morain

Abstract

Since the discovery of Helicobacter pylori in 1982, this Gram-negative bacterium has been associated with a variety of clinical conditions. The bacterium was initially reported to be present in 80–100% of duodenal ulcer patients. In recent larger studies, with improved diagnostic techniques, the prevalence of H. pylori in uncomplicated duodenal ulcers is reported to be approximately 95%1. Duodenal ulcer disease is usually a chronic recurrent condition in untreated individuals. In excess of 50% of patients have dyspeptic symptoms for more than 2 years before presentation. In the pre-H. pylori era, of patients who were followed for 1 year after ulcer healing, 57% had one or two recurrences, 7% had more than three recurrences and 36% remained symptom-free2. Overall 50–80% of duodenal ulcer patients will have a recurrence during a 12-month follow-up after healing. Eradication of H. pylori alters the natural history of peptic ulcer disease and virtually abolishes ulcer relapse rates during 1 year follow-up3.

Keywords

Peptic Ulcer Duodenal Ulcer Pylorus Infection Peptic Ulcer Disease Systemic Mastocytosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers and Axcan Pharma 1996

Authors and Affiliations

  • M. Buckley
  • J. Lee
  • C. O’Morain

There are no affiliations available

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