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Genetic bases for heterogeneity of Helicobacter pylori

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Helicobacter pylori

Abstract

Diversity, a characteristic of all living things, has long been recognized among microorganisms and has been well appreciated among bacteria1. For pathogenic microbes, those whose lifestyle results in injury to their larger hosts, a central notion is that these often represent clonal populations. In this context clonality represents a common ancestry, and a very close if not identical genetic relationship among the members of a group.

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References

  1. Smith JM. Population genetics: an introduction. In: Smith JM, Neidhardt FC, editors. Escherichia coli and Salmonella. Cellular and molecular biology. Washington, DC: ASM Press; 1996:2685–90.

    Google Scholar 

  2. Hermans PMW, Van Soolingen D, Dale JW et al. Insertion element IS906 from Mycobacterium tuberculosis: a useful tool for diagnosis and epidemiology of tuberculosis. J Clin Microbiol. 1990;28:2051–8.

    PubMed  CAS  Google Scholar 

  3. Blaser MJ, Miotto K, Hopkins JA. Molecular probe analysis of Shigella dysenteriae type I isolates from 1940 to 1987. Int J Epidemiol. 1992;21:594–8.

    Article  PubMed  CAS  Google Scholar 

  4. Strockbine NA, Paronnet J, Greene K, Kiehlbauch JA, Wachsmuth IK. Molecular epidemiologic techniques in analysis of epidemic Shigella dysenteriae type 1 strains. J Infect Dis. 1991; 163:406–9.

    Article  PubMed  CAS  Google Scholar 

  5. Salama SM, Jiang Q, Chang N, Sherbaniuk RW, Taylor DE. Characterization of chromosomal DNA profiles from Helicobacter pylori strains isolated from sequential gastric biopsies. J Clin Microbiol. 1995;33:2496–7.

    PubMed  CAS  Google Scholar 

  6. Xia HX, Windle HJ, Marshall DG, Smyth CJ, Keane CT, Omorain CA. Recrudescence of Helicobacter pylori after apparently successful eradication: novel application of randomly amplified polymorphic DNA fingerprinting. Gut. 1995;37:30–4.

    Article  PubMed  CAS  Google Scholar 

  7. Fujimoto S, Marshall B, Blaser MJ. PCR-based restriction fragment length polymorphism typing of Helicobacter pylori. J Clin Microbiol. 1994;32:331–4.

    PubMed  CAS  Google Scholar 

  8. Tee W, Lambert J, Smallwood R, Schembri M, Ross BC, Dwyer B. Ribotyping of Helicobacter pylori from clinical specimens. J Clin Microbiol. 1992;30:1562–7.

    PubMed  CAS  Google Scholar 

  9. Clayton CL, Kleanthous H, Morgan DD, Puckey L, Tabaqchali S. Rapid fingerprinting of Helicobacter pylori by polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol. 1993;31:1420–5.

    PubMed  CAS  Google Scholar 

  10. Lopez CR, Owen RJ, Desai M. Differentiation between isolates of Helicobacter pylori by PCR-RFLP analysis of urease A and B genes and comparison with ribosomal RNA gene patterns. FEMS Microbiol Lett. 1993;110:37–43.

    Article  PubMed  CAS  Google Scholar 

  11. Prewett EJ, Bickley J, Owen RJ, Pounder RE. DNA patterns of Helicobacter pylori isolated from gastric antrum, body, and duodenum. Gastroenterology. 1992;102:829–33.

    PubMed  CAS  Google Scholar 

  12. Foxall PA, Hu LT, Mobley HL. Use of polymerase chain reaction-amplified Helicobacter pylori urease structural genes for differentiation of isolates. J Clin Microbiol. 1992;30:739–41.

    PubMed  CAS  Google Scholar 

  13. Kansau I, Raymond J, Bingen E. Genotyping of Helicobacter pylori isolates by sequencing of PCR products and comparison with the RAPD technique. Res Microbiol. 1996 (In press).

    Google Scholar 

  14. Atherton JC, Cao P, Peek RM, Tummuru MKR, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori; association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270:17771–7.

    Article  PubMed  CAS  Google Scholar 

  15. Wang Y, Roos KP, Taylor DE. Transformation of Helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker. J Gen Microbiol. 1993;139:2485–93.

    PubMed  CAS  Google Scholar 

  16. Ferrero RL, Cussac V, Courcoux P, Labigne A. Construction of isogenic unease-negative mutants of Helicobacter pylori by allelic exchange. J Bacteriol. 1992;174:4212–17.

    PubMed  CAS  Google Scholar 

  17. Cover TL, Dooley CP, Blaser MJ. Characterization of, and human serologic response to, proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun. 1990;58:603–10.

    PubMed  CAS  Google Scholar 

  18. Crabtree JE, Taylor JD, Wyatt JI et al. Mucosal IgA recognition of Helicobacter pylori 120kDa protein, peptic ulceration, and gastric pathology. Lancet. 1991;338:332–5.

    Article  PubMed  CAS  Google Scholar 

  19. Tummuru MKR, Cover TL, Blaser MJ. Cloning and expression of a high molecular weight major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun. 1993; 61:1799–809.

    PubMed  CAS  Google Scholar 

  20. Covacci A, Censini S, Bugnoli M et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA. 1993;90:5791–5.

    Article  PubMed  CAS  Google Scholar 

  21. Akopyants JS, Kersulyte D, Berg DE. CagII, a new multigene locus associated with virulence in Helicobacter pylori. Gut. 1995;37(Suppl. 1):A1.

    Article  Google Scholar 

  22. Lang N, Censini S, Xiang Z et al. The cagI chromosomal region of Helicobacter pylori is type-1 specific and encodes exporter molecules and invasion genes. 8th International Workshop on Campylobacters, Helicobacter and Related Organisms. Winchester, UK: 1995;E2/3 (abstract).

    Google Scholar 

  23. Tummuru MKR, Sharma SA, Blaser MJ. Helicobacter pylori picB, a homolog of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol. 1995;18:867–76.

    Article  PubMed  CAS  Google Scholar 

  24. Kersulyte D, Akopyants NS, Clifton S, Roe BS, Berg DE. IS605, a novel chimaeric transposable element from Helicobacter pylori. Abstracts of the Annual Meeting of the American Society of Microbiology. Washington, DC: ASM Press; 1996;B-62 (abstract).

    Google Scholar 

  25. Höök-Nikanne J, Tummuru MKR, Kersulyte D et al. IS605, a novel transposable element, suitable for typing Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. Gastroenterology. 1996;A135 (abstract).

    Google Scholar 

  26. Taylor DE, Eaton M, Chang N, Salama SM. Construction of a Helicobacter pylori genome map and demonstration of diversity at the genome level. J Bacteriol. 1992;174:6800–6.

    PubMed  CAS  Google Scholar 

  27. Bukanov NO, Berg DE. Ordered cosmid library and high-resolution physical-genetic map of Helicobacter pylori strain NCTC11638. Mol Microbiol. 1994;11:509–23.

    Article  PubMed  CAS  Google Scholar 

  28. Penfold SS, Lastovica AJ, Elisha BG. Demonstration of plasmids in Campylobacter pylori (letter). J Infect Dis. 1988;157:850–1.

    Article  PubMed  CAS  Google Scholar 

  29. Simor AE, Shames B, Drumm B, Sherman P, Low DE, Penner JL. Typing of Campylobacter pylori by bacterial DNA restriction endonuclease analysis and determination of plasmid profile. J Clin Microbiol. 1990;28:83–6.

    PubMed  CAS  Google Scholar 

  30. Tjia TN, Harper WES, Goodwin CS, Grubb WB. Plasmids in Campylobacter pyloridi. Microbiol Lett. 1987;36:7–11.

    Google Scholar 

  31. Minnis JA, Taylor TE, Knesek JE, Peterson WL, McIntire SA. Characterization of a 3.5-kbp plasmid from Helicobacter pylori. Plasmid. 1995;34:22–36.

    Article  PubMed  CAS  Google Scholar 

  32. Kleanthous H, Clayton CL, Tabaqchali S. Characterization of a plasmid from Helicobacter pylori encoding a replication protein common to plasmids in gram-positive bacteria. Mol Microbiol. 1991;5:2377–89.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. M. J. Blaser
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1996 Kluwer Academic Publishers and Axcan Pharma

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Blaser, M.J. (1996). Genetic bases for heterogeneity of Helicobacter pylori . In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_3

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  • DOI: https://doi.org/10.1007/978-94-009-1792-7_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

  • eBook Packages: Springer Book Archive

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