Essential co-factors in gastric carcinogenesis
There is now a large body of evidence which supports the association between Helicobacter pylori infection and an increased risk of gastric cancer. This is reflected in the decision by the International Agency for Cancer Research to categorize H. pylori infection as a definite cause of human cancer1. It is, however, readily apparent that, whereas infection with H. pylori is an extremely common event, gastric cancer is a relatively rare outcome of such infection. For every 100 people infected, no more than five, and probably only one or two, are likely to develop a malignancy. This poses the problem of how to identify the small percentage of infected individuals who are at increased risk of cancer. Clearly unravelling the co-factors involved in the process may be of public health significance, and should help in improving the focus of screening programmes which have, as their objective, preventing the future occurrence of gastric cancer.
KeywordsGastric Cancer Pylorus Infection Atrophic Gastritis Gastric Carcinogenesis Gastric Lymphoma
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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