In vivo studies of emergent issues in gastric Helicobacter pathogenesis and epidemiology

  • J. G. Fox


Since the original description of the bacterium by Warren and Marshall in 1983, Helicobacter pylori is now causally linked to a variety of pathological conditions of the human stomach, such as chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and, most recently, gastric mucosa-associated lymphoid tissue lymphoma1–6. The discovery of H. pylori, and its emerging importance in gastric disease, has generated an enormous interest in dissecting the pathogenesis and epidemiology of H. pylori infection7,8. Early studies failed to establish H. pylori in animal models and, surprisingly, Koch’s postulates were initially fulfilled in two human volunteers9–11. These individuals suffered bouts of acute gastric symptomatology a few days after oral challenge with H. pylori, and in one of them a persistent gastritis was established10,11.


Gastric Mucosa Pylorus Infection Clinical Cure Pylorus Strain Pylorus Isolate 
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Copyright information

© Kluwer Academic Publishers and Axcan Pharma 1996

Authors and Affiliations

  • J. G. Fox

There are no affiliations available

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