Effects of infection with Helicobacter pylori on gastric epithelium

  • S. E. Crowe
  • X. Fan
  • S. Behar
  • G. Ye


There is growing evidence to support a key role for the gastric epithelium in the pathogenesis of Helicobacter pylori-associated gastroduodenal disorders. H. pylori is largely regarded as a non-invasive pathogen, yet is capable of inducing a significant inflammatory response. The concept that the epithelium could play an active role in H. pylori-associated inflammation has been substantiated over the past few years by work from several laboratories (reviewed by others in refs 1 and 2). In these studies gastric epithelial production of interleukin-8 (IL-8), a cytokine with potent neutrophil chemotactic and activating properties3,4, was significantly increased during H. pylori infection5–9. More recent data suggest that other chemokines including members of the C-C family that stimulate lymphocytes and monocytes/macrophages, are also expressed by gastric epithelial cells in response to H. pylori infection. Gastric epithelial cells are also capable of interacting with immune and inflammatory cells through adhesion or immune accessory molecules including Class II MHC, invariant chain (Ii), intracellular adhesion molecule (ICAM)-1, lymphocyte function antigen (LFA)-3, and B7. Expression of such molecules is increased by H. pylori infection with both direct and indirect events involved in the enhanced expression. Together, this information provides a basis to establish potential mechanisms whereby the epithelium can signal immune cells to establish the gastritis associated with H. pylori infection. In turn, immune or inflammatory cells may mediate alterations of the gastric epithelium that occur during H. pylori infection.


Pylorus Infection Gastric Epithelial Cell Gastric Epithelium Accessory Molecule Gastric Epithelial Cell Line 
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© Kluwer Academic Publishers and Axcan Pharma 1996

Authors and Affiliations

  • S. E. Crowe
  • X. Fan
  • S. Behar
  • G. Ye

There are no affiliations available

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