Skip to main content
SpringerLink
Log in

Helicobacter pylori gastritis and gastric acid secretory function — an integrated approach

  • Chapter
Helicobacter pylori

  • 77 Accesses

Abstract

There is evidence of a two-way relationship between gastric acid secretory function and H. pylori-associated gastritis. Gastric acid secretory function influences the density of H. pylori colonization, its distribution within the stomach and the severity of the mucosal inflammatory response to the infection. In addition, H. pylori gastritis alters gastric acid secretion. In subjects with a predominant antral gastritis it increases acid secretion predisposing to duodenal ulcers (DU), whereas in others, with predominant body gastritis, acid secretion is impaired and the subjects have an increased risk of gastric cancer. In this chapter we discuss the interaction between gastric acid secretory function and H. pylori gastritis and its importance in determining disease outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Graham DY, Opekum A, Lew GM, Evans DJ, Klein PD, Evans DG. Ablation of exaggerated meal-stimulated gastrin release in duodenal ulcer patients after clearance of Helicobacter (Campylobacter) pylori infection. Am J Gastroenterol. 1990;85:394–8.

    PubMed  CAS  Google Scholar 

  2. Levi S, Beardshall K, Desa LA, Calam J. Campylobacter pylori, gastrin, acid secretion and duodenal ulcers. Lancet. 2;613.

    Google Scholar 

  3. Smith JTL, Pounder RE, Nwokolo CU et al. Inappropriate hypergastrinaemia in asymptomatic healthy subjects infected with Helicobacter pylori. Gut. 1990;31:522–5.

    Article  PubMed  CAS  Google Scholar 

  4. McColl KEL, Fullarton GM, Chittajallu R et al. Plasma gastrin, daytime intragastric pH, and nocturnal acid output before and at 1 and 7 months after eradication of Helicobacter pylori in duodenal ulcer subjects. Scand J Gastroenterol. 1991;26:339–46.

    Article  PubMed  CAS  Google Scholar 

  5. El-Omar E, Penman ID, Ardill JES, Chittajallu RS, Howie C, McColl KEL. Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology. 1995;109:681–91.

    Article  PubMed  CAS  Google Scholar 

  6. El-Omar E, Penman I, Dorrian CA, Ardill JES, McColl KEL. Eradicating Helicobacter pylori infection lowers gastrin mediated acid secretion by two thirds in patients with duodenal ulcer. Gut. 1993;34:1060–5.

    Article  PubMed  CAS  Google Scholar 

  7. Mulholland G, Ardill JES, Fillmore D, Chittajallu RS, Fullarton GM, McColl KEL. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut. 1993; 34:757–61.

    Article  PubMed  CAS  Google Scholar 

  8. Kaneko H, Nakada K, Mitsuma T et al. Helicobacter pylori infection induces a decrease in immunoreactive-somatostatin concentrations of human stomach. Dig Dis Sci. 1992;37:409–16.

    Article  PubMed  CAS  Google Scholar 

  9. Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992;340:930–2.

    Article  PubMed  CAS  Google Scholar 

  10. Queiroz DMM, Mendes EN, Rocha GA et al. Effect of Helicobacter pylori eradication on antral gastrin- and somatostatin-immunoreactive cell density and gastrin and somatostatin concentrations. Scand J Gastroenterol. 1993;28:858–64.

    Article  PubMed  CAS  Google Scholar 

  11. Graham DY, Lew GM, Lechago J. Antral G-cell and D-cell numbers in Helicobacter pylori infection: effect of H. pylori eradication. Gastroenterology. 1993;104:1655–60.

    PubMed  CAS  Google Scholar 

  12. Sumii M, Summi K, Tari A et al. Expression of antral gastrin and somatostatin mRNA in Helicobacter pylori-infected subjects. Am J Gastroenterol. 1994;89:1515–19.

    PubMed  CAS  Google Scholar 

  13. Chittajallu RS, Ardill JES, McColl KEL. The degree of hypergastrinaemia induced by Helicobacter pylori is the same in duodenal ulcer patients and asymptomatic volunteers. Eur J Gastroenterol Hepatol. 1992;4:49–53.

    Google Scholar 

  14. Graham DY, Go MF, Lew GM, Genta RM, Rehfeld JE Helicobacter pylori infection and exaggerated gastrin release. Effects of inflammation and progastrin processing. Scand J Gastroenterol. 1993;28:690–4.

    Article  PubMed  CAS  Google Scholar 

  15. Moss SF, Calam J. Acid secretion and sensitivity to gastrin in patients with duodenal ulcer: effect of eradication of Helicobacter pylori. Gut. 1993;34:888–92.

    Article  PubMed  CAS  Google Scholar 

  16. Harris AW, Gummett PA, Misiewicz JJ, Baron JH. Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin. Gut. 1996;38:663–8.

    Article  PubMed  CAS  Google Scholar 

  17. Gillen D, El-Omar E, McColl KEL. Parietal cell sensitivity to gastrin distinguishes H. pylori D.U. patients from H. pylori infected healthy volunteers. Gastroenterology. 1996; 110:A116.

    Article  Google Scholar 

  18. Pisegna JR, Norton JA, Slimak GG et al. Effect of curative gastrinoma resection on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome. Gastroenterology. 1992;102:767–78.

    PubMed  CAS  Google Scholar 

  19. Montbriand JR, Appelman HD, Cotner EK, Nostrant TT, Elta GH. Treatment of Campylobacter pylori does not alter gastric acid secretion. Am J Gastroenterol. 1989;84:1513–16.

    PubMed  CAS  Google Scholar 

  20. Harris AW, Gummett PA, Walker MM, Misiewicz JJ, Baron JH. The relationship between gastric acid output, Helicobacter pylori and gastric metaplasia in the duodenal bulb. Gut. 1996 (in press).

    Google Scholar 

  21. Khulusi S, Badve S, Patel P et al. Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration. Gastroenterology. 1996; 110:452–8.

    Article  PubMed  CAS  Google Scholar 

  22. Tucci A, Poli L, Paparo GF et al. Effect of Helicobacter pylori (HP) eradication in patients with fundic atrophic gastritis. Gut. 1994;35(Suppl. 4): 1514.

    Google Scholar 

  23. Yasunaga Y, Shinomura Y, Kanayam S et al. Improved fold width and increased acid secretion after eradication of the organism in Helicobacter pylori associated enlarged fold gastritis. Gut. 1994;35:1571–4.

    Article  PubMed  CAS  Google Scholar 

  24. El-Omar E, Oien K, Wirz A, Mccoll KEL. Divergent effects of H. pylori on acid secretion. Gastroenterology. 1996;110:A102.

    Article  Google Scholar 

  25. Parsonnet J, Friedman GD, Vandersteen DP et al. Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med. 1991;325:1127 – 31.

    Article  PubMed  CAS  Google Scholar 

  26. Forman D, Newell DG, Fullerton F et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br Med J. 1991;302:1302–5.

    Article  CAS  Google Scholar 

  27. Nomura A, Stemmermann GN, Po-Huang C, Kato I, Perez-Perez GI, Blaser MJ. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N Engl J Med. 1991;325:1132–6.

    Article  PubMed  CAS  Google Scholar 

  28. Lee A, Dixon MF, Danon SJ et al. Local acid production and Helicobacter pylori — a unifying hypothesis of gastroduodenal disease. Eur J Gastroenterol Hepatol. 1995;7:461–5.

    PubMed  CAS  Google Scholar 

  29. Logan RPH, Walker MM, Misiewicz JJ, Gummett PA, Karim QN, Baron JH. Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut. 1995;36: 12–16.

    Article  PubMed  CAS  Google Scholar 

  30. Kuipers EJ, Uyterlinde AM, Pena AS et al. Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for longterm safety. Am J Gastroenterol. 1995;90:1401–6.

    PubMed  CAS  Google Scholar 

  31. Solcia E, Villani L, Fiocca R et al. Effects of eradication of Helicobacter pylori on gastritis in duodenal ulcer patients. Scand J Gastroenterol. 1994;29(Suppl. 201):28–34.

    Article  Google Scholar 

  32. Solcia E, Fiocca R, Havu N, Dalvag A, Carlsson R. Gastric endocrine cells and gastritis in patients receiving long-term omeprazole treatment. Digestion. 1992;5(Suppl. 1):82–92.

    Article  Google Scholar 

  33. Kuipers EJ, Uyterlinde AM, Pena AS et al. Increase of Helicobacter pylori-associated corpus gastritis during acid suppressive therapy: implications for longterm safety. Am J Gastroenterol. 1995;90:1401–6.

    PubMed  CAS  Google Scholar 

  34. Kuipers EJ, Lee A, Klinkenberg-Knol EC, Meuwissen SGM. Review article: The development of atrophic gastritis — Helicobacter pylori and the effects of acid suppressive therapy. Aliment Pharmacol Ther. 1995;9:331–40.

    Article  PubMed  CAS  Google Scholar 

  35. Verdu EF, Armstrong D, Fraser R et al. Effect of Helicobacter pylori status on intragastric pH during treatment with omeprazole. Gut. 1995;36:539–43.

    Article  PubMed  CAS  Google Scholar 

  36. Verdu EF, Armstrong D, Idstrom J-P et al. Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole. Gut. 1995;37:743–8.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. K. E. L. McColl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Gillen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. El-Omar
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Oien
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. Dahill
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Room 4W8, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers and Axcan Pharma

About this chapter

Cite this chapter

McColl, K.E.L., Gillen, D., El-Omar, E., Oien, K., Dahill, S. (1996). Helicobacter pylori gastritis and gastric acid secretory function — an integrated approach. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1792-7_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1792-7_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7299-1

  • Online ISBN: 978-94-009-1792-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation