Abstract
A single alveolus is used to simulate a breathing cycle in human lungs. An alveolus elastic wall lined with liquid is deformed to accommodate the intrapleural pressure changes. The difference in pressure between alveolus and surroundings is established and the air flow is followed. The main focus, however, is on normal and pathological inhomogeneities which are implemented into the model as decreased tissue elasticity, surfactant deficiency, and constriction of airways. Under such conditions, particle transport and deposition patterns distinguish from those observed in normal healthy lungs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gradon L., Orlicki D., Deposition of inhaled Aerosol Particles in a Generation of the Tracheobronchial Tree, J. Aerosol Sci. 22, 15–30, 1990,
Balashazy I., Hofmann W., Deposition of Aerosols in Asymmetric Airway Bifurcations, J. Aerosol Sci. 26, 273–292, 1995,
Orlicki D., Mathematical Modeling of Aerosol Deposition in Human Respiratory Tracts, Ph.D. Thesis, Warsaw University of Technology, Warsaw, Poland, 1988,
Weibel E. R., Morphometry of the Human Lung, Academic Press, New York, 1963,
Olson D. E., Dart G. A., and Filley G. F., Pressure drop and fluid flow regime of air inspired into the human lungs, J. Appl. Physiol. 28: 482–484, 1970,
Gallagher R. H., Simon B. R., Johnson P. C., and Gross J. F., Finite Elements in Biomechanics, Wiley, New York, 1982.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Kluwer Academic Publishers
About this chapter
Cite this chapter
Orlicki, D.S., Gradon, L. (1996). The Influence of Normal and Pathological Inhomogeneities of the Lung Tissues on Particle Transport and Deposition. In: Marijnissen, J.C.M., Gradoń, L. (eds) Aerosol Inhalation: Recent Research Frontiers. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1694-4_12
Download citation
DOI: https://doi.org/10.1007/978-94-009-1694-4_12
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-7259-5
Online ISBN: 978-94-009-1694-4
eBook Packages: Springer Book Archive