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Circadian variation in the onset of myocardial infarction and sudden cardiac death

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Triggering of Acute Coronary Syndromes

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 170))

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Abstract

Study of triggering of the acute coronary syndromes received great stimulus from the relatively simple observation that the disorders have a prominent circadian variation of onset. The widespread recognition of the morning increase of myocardial infarction [1] and sudden cardiac death [2] has convinced many that the activities of the morning “trigger” onset of a sizeable percentage of the events.

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References

  1. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. [Review] Circulation 1989; 79: 733–43.

    Article  PubMed  CAS  Google Scholar 

  2. Muller JE, Ludmer PL, Willich SN et al. Circadian variation in the frequency of sudden cardiac death. Circulation 1987; 75: 131–8.

    Article  PubMed  CAS  Google Scholar 

  3. Thompson DR, Blandford RL, Sutton TW, Marchant PR. Time of onset of chest pain in acute myocardial infarction. Int J Cardiol 1985; 7: 139–48.

    Article  PubMed  CAS  Google Scholar 

  4. Myers A, Dewar HA. Circumstances attending 100 sudden deaths from coronary artery disease with coroner’s necropsies. Br Heart J 1975; 37: 1133–43.

    Article  PubMed  CAS  Google Scholar 

  5. World Health Organization. Myocardial infarction community registers: results of a WHO international collaborative study coordinated by the regional office for Europe. 1976; Copenhagen: Regional Office for Europe: World Health Organization. 5: 1 p. Public Health in Europe.

    Google Scholar 

  6. Muller JE, Stone PH, Turi ZG et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313: 1315–22.

    Article  PubMed  CAS  Google Scholar 

  7. Willich SN, Linderer T, Wegscheider K, Leizorovicz A, Alamercery I, Schroder R. Increased morning incidence of myocardial infarction in the ISAM Study: absence with prior beta-adrenergic blockade. ISAM Study Group. Circulation 1989; 80: 853–8.

    Article  PubMed  CAS  Google Scholar 

  8. Goldberg RJ, Brady P, Muller JE et al. Time of onset of symptoms of acute myocardial infarction. Am J Cardiol 1990; 66: 140–4.

    Article  PubMed  CAS  Google Scholar 

  9. Willich SN, Löwel H, Lewis M et al. Association of waketime and the onset of myocardial infarction: TRIM (Triggers and Mechanisms of myocardial Infarction) Pilot Study. Circulation 1991; 84(Suppl): VI-62–7.

    Google Scholar 

  10. Kleiman NS, Schechtman KB, Young PM et al. Lack of diurnal variation in the onset of non-Q wave infarction. Circulation 1990; 81: 548–55.

    Article  PubMed  CAS  Google Scholar 

  11. Ogawa H, Misumi I, Masuda T, Sakamoto T, Okubo H, Miyao Y. Difference in plasminogen activator inhibitor-1 (PAI-1) activity between Q wave infarction and Non-Q wave infarction. Circulation 1991; 84: II-289 (Abstract).

    Google Scholar 

  12. DeWood MA, Spores J, Notske R et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med 1980; 303: 897–902.

    Article  PubMed  CAS  Google Scholar 

  13. Ambrose JA, Winters SL, Stern A et al. Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol 1985; 5: 609–16.

    Article  PubMed  CAS  Google Scholar 

  14. Sherman CT, Litvack F, Grundfest W et al. Coronary angioscopy in patients with unstable angina pectoris. N Engl J Med 1986; 315: 913–9.

    Article  PubMed  CAS  Google Scholar 

  15. Constantinides P. Plaque fissure in human coronary thrombosis. J Atherosclerosis Res 1966; 1: 1–17.

    Article  Google Scholar 

  16. Nakagawa S, Hanada Y, Koiwaya Y, Tanaka K. Angiographic features in the infarct-related artery after intracoronary urokinase followed by prolonged anticoagulation. Role of ruptured atheromatous plaque and adherent thrombus in acute myocardial infarction in vivo. Circulation 1988; 78: 1335–44.

    Article  PubMed  CAS  Google Scholar 

  17. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J 1983; 50: 127–34.

    Article  PubMed  CAS  Google Scholar 

  18. Little WC, Constantinescu M, Applegate RJ et al. Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease? Circulation 1988; 78: 1157–66.

    Article  PubMed  CAS  Google Scholar 

  19. Brown BG, Gallery CA, Badger RS et al. Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction: quantitative angiographic observations. Circulation 1986; 73: 653–61.

    Article  PubMed  CAS  Google Scholar 

  20. Haft JI, Haik BJ, Goldstein JE. Catastrophic progression of coronary artery lesions, the common mechanism for coronary disease progression. Circulation 1987; 76: 168.

    Google Scholar 

  21. Richardson PD, Davies MJ, Born GV. Influence of plaque configuration and stress distribution on Assuring of coronary atherosclerotic plaques. Lancet 1989; 2: 941–4.

    Article  PubMed  CAS  Google Scholar 

  22. Falk E. Why do plaques rupture? [Review] Circulation 1992; 86: III30–42.

    Google Scholar 

  23. van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimai rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994; 89: 36–44.

    PubMed  Google Scholar 

  24. Fernandez-Ortiz A, Badimon JJ, Falk E et al. Characterization of the relative thrombogenicity of atherosclerotic plaque components: implications for consequences of plaque rupture. J Am Coll Cardiol 1994; 23: 1562–9.

    Article  PubMed  CAS  Google Scholar 

  25. Alexander RW. Inflammation and coronary artery disease (editorial; comment). N Engl J Med 1994; 331: 468–9.

    Article  PubMed  CAS  Google Scholar 

  26. Toiler GH, Brezinski D, Schafer AI et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 1987; 316: 1514–8.

    Article  Google Scholar 

  27. Jimenez AH, Toiler GH, Chen X, Stubbs ME, Solomon HS, Muller JE. Effects of nadolol on hemodynamic and hemostatic responses to potential mental and physical triggers of myocardial infarction in subjects with mild systemic hypertension. Am J Cardiol 1993; 72: 47–52.

    Article  PubMed  CAS  Google Scholar 

  28. Behar S, Halabi M, Reicher-Reiss H et al. Circadian variation and possible external triggers of onset of myocardial infarction. SPRINT Study Group. Am J Med 1993; 94: 395–400.

    Article  PubMed  CAS  Google Scholar 

  29. Weitzman ED, Fukushima D, Nogeire C, Roffwarg H, Gallagher TF, Hellman L. Twenty-four hour pattern of the episodic secretion of Cortisol in normal subjects. J Clin Endocrinol Metabolism 1971; 33: 14–22.

    Article  CAS  Google Scholar 

  30. Winther K, Hillegass W, Toiler GH et al. Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men. Am J Cardiol 1992; 70: 1051–5.

    Article  PubMed  CAS  Google Scholar 

  31. Peters RW, Zoble RG, Liebson PR, Pawitan Y, Brooks MM, Proschan M. Identification of a secondary peak in myocardial infarction onset 11 to 12 hours after awakening: the Cardiac Arrhythmia Suppression Trial (CAST) experience. J Am Coll Cardiol 1993; 22: 998–1003.

    Article  PubMed  CAS  Google Scholar 

  32. Somers VK, Dyken ME, Mark AL, Abboud FM. Sympathetic-nerve activity during sleep in normal subjects. N Engl J Med 1993; 328: 303–7.

    Article  PubMed  CAS  Google Scholar 

  33. Fan WH, Dai RH. Further studies on the factors influencing the onset of acute myocardial infarction. Chin J Prev Med 1993; 27: 337–9.

    CAS  Google Scholar 

  34. Rose G. Cold weather and ischaemic heart disease. Br J Prev Social Med 1966; 20: 97–100.

    CAS  Google Scholar 

  35. Anderson T, Rochard C. Cold snaps, snowfall, and sudden death from ischemic heart disease. Can Med J 1979; 121: 1580–3.

    CAS  Google Scholar 

  36. Marchant B, Ranjadayalan K, Stevenson R, Wilkinson P, Timmis AD. Circadian and seasonal factors in the pathogenesis of acute myocardial infarction: the influence of environmental temperature. Br Heart J 1993; 69: 385–7.

    Article  PubMed  CAS  Google Scholar 

  37. Willich SN, Lowel H, Lewis M, Hormann A, Arntz HR, Keil U. Weekly variation of acute myocardial infarction. Increased Monday risk in the working population. Circulation 1994; 90: 87–93.

    PubMed  CAS  Google Scholar 

  38. Hansen O, Johansson BW, Gullberg B. Circadian distribution of onset of acute myocardial infarction in subgroups from analysis of 10,791 patients treated in a single center. Am J Cardiol 1992; 69: 1003–8.

    Article  PubMed  CAS  Google Scholar 

  39. Peters RW, Muller JE, Goldstein S, Byington R, Friedman LM. Propranolol and the morning increase in the frequency of sudden cardiac death (BHAT Study). Am J Cardiol 1989; 63:1518–20.

    Article  PubMed  CAS  Google Scholar 

  40. Ridker PM, Manson JE, Buring JE, Muller JE, Hennekens CH. Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicians. Circulation 1990; 82: 897–902.

    Article  PubMed  CAS  Google Scholar 

  41. Mulcahy D, Keegan J, Cunningham D et al. Circadian variation of total ischaemic burden and its alteration with anti-anginal agents. Lancet 1988; 2: 755–9.

    Article  PubMed  CAS  Google Scholar 

  42. Parker JD, Testa MA, Jimenez AH et al. Morning increase in ambulatory ischemia in patients with stable coronary artery disease. Importance of physical activity and increased cardiac demand. Circulation 1994; 89: 604–14.

    PubMed  CAS  Google Scholar 

  43. Kurnik PB. Circadian variation in the efficacy of t-PA. Circulation 1991; 84: 289 (Abstract).

    Google Scholar 

  44. Fujita M, Araie E, Yamanishi K, Miwa K, Kida M, Nakajima H. Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction. Am J Cardiol 1993; 71: 1369–71.

    Article  PubMed  CAS  Google Scholar 

  45. Hansen O, Johansson BW, Gullberg B. The clinical outcome of acute myocardial infarction is related to the circadian rhythm of myocardial infarction onset. Angiology 1993; 44: 509–16.

    Article  PubMed  CAS  Google Scholar 

  46. Muller JE, Abela GS, Nesto RW, Tofler GH. Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier. J Am Coll Cardiol 1994; 23: 809–13.

    Article  PubMed  CAS  Google Scholar 

  47. Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med 1984; 310: 1137–40.

    Article  PubMed  CAS  Google Scholar 

  48. Ip JH, Fuster V, Badimon L, Badimon J, Taubman MB, Chesebro JH. Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation. [Review] J Am Coll Cardiol 1990; 15: 1667–87.

    Article  PubMed  CAS  Google Scholar 

  49. Willerson JT, Campbell WB, Winniford MD et al. Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. Am J Cardiol 1984; 54: 1349–54.

    Article  PubMed  CAS  Google Scholar 

  50. Coller BS, Folts JD, Smith SR, Scudder LE, Jordan R. Abolition of in vivo platelet thrombus formation in primates with monoclonal antibodies to the platelet GPIIb/IIIa receptor. Correlation with bleeding time, platelet aggregation, and blockade of GPIIb/IIIa receptors. Circulation 1989; 80: 1766–74.

    Article  PubMed  CAS  Google Scholar 

  51. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (2). N Engl J Med 1992; 326: 310–8.

    Article  PubMed  CAS  Google Scholar 

  52. Arbustini E, Grasso M, Diegoli M et al. Coronary thrombosis in non-cardiac death. Coronary Artery Dis 1993; 4: 751–9.

    Article  CAS  Google Scholar 

  53. Belch JJ, McArdle BM, Burns P, Lowe GD, Forbes CD. The effects of acute smoking on platelet behaviour, fibrinolysis and haemorheology in habitual smokers. Thrombosis Haemostasis 1984; 51: 6–8.

    CAS  Google Scholar 

  54. Egan B, Schork N, Panis R, Hinderliter A. Vascular structure enhances regional resistance responses in mild essential hypertension. J Hypertension 1988; 6: 41–8.

    Article  CAS  Google Scholar 

  55. Ludmer PL, Selwyn AP, Shook TL et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986; 315: 1046–51.

    Article  PubMed  CAS  Google Scholar 

  56. Khanna PK, Seth HN, Balasubramanian V, Hoon RS. Effect of submaximal exercise on fibrinolytic activity in ischaemic heart disease. Br Heart J 1975; 37: 1273–6.

    Article  PubMed  CAS  Google Scholar 

  57. Gillum RF. Sudden coronary death in the United States: 1980–1985. Circulation 1989; 79: 756–65.

    Article  PubMed  CAS  Google Scholar 

  58. Goldberg J. Declining out-of-hospital sudden coronary death rates: additional pieces of the epidemiologic puzzle. Circulation 1989; 79: 1369–73.

    Article  PubMed  CAS  Google Scholar 

  59. Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death. Structure, function, and time-dependence of risk. Circulation 1992; 85: I2–10.

    PubMed  CAS  Google Scholar 

  60. Lown B. Sudden cardiac death: the major challenge confronting contemporary cardiology. Am J Cardiol 1979; 43: 313–28.

    Article  PubMed  CAS  Google Scholar 

  61. Gallerani M, Manfredini R, Ricci L et al. Sudden death may show a circadian time of risk depending on its anatomo-clinical causes and age. Jpn Heart J 1993; 34: 729–39.

    Article  PubMed  CAS  Google Scholar 

  62. Hinkle LE, Jr., Thaler HT. Clinical classification of cardiac deaths. Circulation 1982; 65: 457–64.

    Article  PubMed  Google Scholar 

  63. Lovegrove T, Thompson P. The role of acute myocardial infarction in sudden cardiac death-a statistician’s nightmare. Am Heart J 1978; 96: 711–3.

    Article  PubMed  CAS  Google Scholar 

  64. Goldstein S. Toward a new understanding of the mechanism and prevention of sudden death in coronary heart disease. [Review] Circulation 1990; 82: 284–8.

    Article  PubMed  CAS  Google Scholar 

  65. Davies MJ. Anatomic features in victims of sudden coronary death. Coronary artery pathology. Circulation 1992; 85: I19–24.

    PubMed  CAS  Google Scholar 

  66. Goldstein S, Landis JR, Leighton R et al. Characteristics of the resuscitated out-of-hospital cardiac arrest victim with coronary heart disease. Circulation 1981; 64: 977–84.

    Article  PubMed  CAS  Google Scholar 

  67. Willich SN, Maclure M, Mittleman M, Arntz HR, Muller JE. Sudden cardiac death. Support for a role of triggering in causation. Circulation 1993; 87: 1442–50.

    PubMed  CAS  Google Scholar 

  68. Willich SN, Levy D, Rocco MB, Tofler GH, Stone PH, Muller JE. Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. Am J Cardiol 1987; 60: 801–6.

    Article  PubMed  CAS  Google Scholar 

  69. Levine RL, Pepe PE, Fromm RE, Curka PA, Clark PA. Prospective evidence of a circadian rhythm for out-of-hospital cardiac arrests. J Am Med Assoc 1992; 267: 2935–7.

    Article  CAS  Google Scholar 

  70. Ishida K, Takagi T, Ohkura K, Yabuki S, Machii K, Ito M. Out-of-hospital sudden cardiac death: a comparative study spanning 10 years. [Japanese]. J Cardiol 1989; 19: 765–73.

    PubMed  CAS  Google Scholar 

  71. Arntz HR, Willich SN, Oeff M et al. Circadian variation of sudden cardiac death reflects age-related variability in ventricular fibrillation. Circulation 1993; 88: 2284–9.

    PubMed  CAS  Google Scholar 

  72. Hausmann D, Trappe HJ, Bargheer K, Daniel WG, Wenzlaff P, Lichtlen PR. Circadian variation of ventricular tachycardia in patients after myocardial infarction. J Am Coll Cardiol 1992; 19: 368A (Abstract).

    Google Scholar 

  73. Willich SN, Goldberg RJ, Maclure M, Perriello L, Muller JE. Increased onset of sudden cardiac death in the first three hours after awakening. Am J Cardiol 1992; 70: 65–8.

    Article  PubMed  CAS  Google Scholar 

  74. Peters RW, Mitchell LB, Brooks MM et al. Circadian pattern of arrhythmic death in patients receiving encainide, flecainide or moricizine in the Cardiac Arrhythmia Suppression Trial (CAST). J Am Coll Cardiol 1994; 23: 283–9.

    Article  PubMed  CAS  Google Scholar 

  75. Gebara OCE, Mittleman M, Rasmussen C, Venditti FJ, Muller JE, Tofler GH. Morning peak in ventricular arrhythmias detected by time of implantable cardioverter defibrillator therapy. Circulation 1995; 92: 1203–8.

    PubMed  Google Scholar 

  76. Karch SB, Billingham ME. The pathology and etiology of cocaine-induced heart disease. Arch Pathol Lab Med 1988; 112: 225–30.

    PubMed  CAS  Google Scholar 

  77. de Silva RA. Central nervous system risk factors for sudden cardiac death. In Greenberg HM, Dwyer EM (eds): Sudden Coronary Death. New York: New York Academy of Sciences 1982; 143–160.

    Google Scholar 

  78. Corbalan R, Verrier R, Lown B. Psychological stress and ventricular arrhythmias during myocardial infarction in the conscious dog. Am J Cardiol 1974; 34: 692–6.

    Article  PubMed  CAS  Google Scholar 

  79. Folts JD, Stamler J, Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation 1991; 83: 2122–7.

    PubMed  CAS  Google Scholar 

  80. Huikuri HV, Linnaluoto MK, Seppanen T et al. Circadian rhythm of heart rate variability in survivors of cardiac arrest. Am J Cardiol 1992; 70: 610–5.

    Article  PubMed  CAS  Google Scholar 

  81. Verrier RL, Nearing BD. Electrophysiologic basis for T wave alternans as an index of vulnerability to ventricular fibrillation. J Cardiovasc Electrophysiol 1994; 5: 445–61.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. James E. Muller
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  2. Stefan N. Willich
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Editors and Affiliations

  1. Institute for Epidemiology, Social and Preventive Medicine, Humboldt University of Berlin, Klinikum Charité, Berlin, Germany

    Stefan N. Willich

  2. Institute for Prevention of Cardiovascular Disease, Deaconess Hospital, Harvard Medical School, Boston, USA

    James E. Muller

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© 1996 Kluwer Academic Publishers

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Muller, J.E., Willich, S.N. (1996). Circadian variation in the onset of myocardial infarction and sudden cardiac death. In: Willich, S.N., Muller, J.E. (eds) Triggering of Acute Coronary Syndromes. Developments in Cardiovascular Medicine, vol 170. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1577-0_4

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  • DOI: https://doi.org/10.1007/978-94-009-1577-0_4

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7205-2

  • Online ISBN: 978-94-009-1577-0

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