Skip to main content
SpringerLink
Log in

Chronopharmacological aspects of coronary heart disease

  • Chapter
Triggering of Acute Coronary Syndromes

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 170))

Abstract

Circadian rhythms in the functions of the cardiovascular system are now well established as indicated in the preceeding chapters and other publications [1,2]. Biological rhythms in heart rate and blood pressure were already described at the end of the 18th and during the 19th century by Zimmermann, 1793, Falconer, 1797, Autenrieth, 1801, Knox, 1815, Wilhelm, 1809, Zadek, 1881 and others [2]. There are also very early reports of the occurrence of nocturnal symptoms and/or onset of angina pectoris attacks and myocardial infarction [3,4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Lemmer B. Temporal aspects in the effects of cardiovascular active drugs in man. In Lemmer B (ed): Chronopharmacology — Cellular and Biochemical Interactions. New York: Marcel Dekker 1989: 525–42.

    Google Scholar 

  2. Lemmer B. The cardiovascular system and daily variation in response to antihypertensive and antianginal drugs: recent advances. Pharmac Ther 1991; 51: 269–74.

    Article  CAS  Google Scholar 

  3. Zimmermann JG. Von der Erfahrung in der Arzneykunst. New edition. Agram: Edlen von Trattnern JT, 1793: 234.

    Google Scholar 

  4. Testa AJ. Über die Krankheiten des Herzens. German translation by Sprengel K. Halle: Gebauer JJ, 1815: 35ff, 321ff.

    Google Scholar 

  5. Lemmer B, Scheidel B, Behne S. Chronopharmacokinetics and chronopharmacodynamics of cardiovascular active drugs: Propranolol, organic nitrates, nifedipine. Ann NY Acad Sci 1991; 618: 166–81.

    Article  PubMed  Google Scholar 

  6. Lemmer B, Winkler H, Ohm T, Fink M. Chronopharmacokinetics of beta-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, Sotalol, atenolol) in plasma and tissues after single and multiple dosing in the rat. Naunyn-Schmiedeberg’s Arch Pharmacol 1985; 330: 42–9.

    Article  CAS  Google Scholar 

  7. Lemmer B, Mattes A, Böhm M, Ganten D. Orcadian blood pressure variation in transgenic hypertensive rats. Hypertension 1993; 22: 97–101.

    PubMed  CAS  Google Scholar 

  8. Lemmer B, Witte K, Makabe T, Ganten D, Mattes A. Effects of enalaprilat on circadian profiles in blood pressure and heart rate of spontaneously and transgenic hypertensive rats. J Cardiovasc Pharmacol 1994; 23: 311–4.

    Article  PubMed  CAS  Google Scholar 

  9. Lemmer B, Bruguerolle B. Chronopharmacokinetics, are they clinically relevant? Clin Pharmacokinet 1994; 26: 419–27.

    Article  PubMed  CAS  Google Scholar 

  10. Norwegian Multicenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 1981; 304: 801–7.

    Article  Google Scholar 

  11. Muller JE, Stone PH, Turi ZG et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313: 1315–22.

    Article  PubMed  CAS  Google Scholar 

  12. Willich SN, Linderer T, Wegscheider K et al. Increased morning incidence of myocardial infarction in the ISAM study: absence with prior ß adrenergic blockade. Circulation 1989; 80: 853–8.

    Article  PubMed  CAS  Google Scholar 

  13. Woods KL, Fletcher S, Jagger C. Modification of the circadian rhythm of onset of acute myocardial infarction by long-term antianginal treatment. Br Heart J 1992; 68: 458–61.

    Article  PubMed  CAS  Google Scholar 

  14. Peters RW, Muller JE, Goldstein S, Byington R, Friedman LM for the BHAT Study Group. Propranolol and the morning increase in the frequency of sudden cardiac death (BHAT study). Am J Cardiol 1989; 63: 1518–20.

    Article  PubMed  CAS  Google Scholar 

  15. Kleiman NS, Schechtman KB, Young PM, Goodman DA, Boden WE, Pratt CM, Roberts R, and the Diltiazem Reinfarction Study investigators. Lack of diurnal variation in the onset of non-Q wave infarction. Circulation 1990; 81: 548–55.

    Article  PubMed  CAS  Google Scholar 

  16. Cohn PF, Lawson WE, Gennaro V, Brady D. Effects of long-acting propranolol on am and pm peaks in silent myocardial ischemia. Am J Cardiol 1989; 63: 872–3.

    Article  PubMed  CAS  Google Scholar 

  17. Imperi GA, Lambert CR, Coy K, Lopez L, Pepine CJ, Shephard C. Effects of titrated beta blockade (metoprolol) on silent myocardial ischemia in ambulatory patients with coronary artery disease. Am J Cardiol 1987; 60: 519–24.

    Article  PubMed  CAS  Google Scholar 

  18. Coy KM, Imperi G, Lambert CR, Pepine CJ. Application of time series analysis to circadian rhythms: effect of beta-adrenergic blockade upon heart rate and transient myocardial ischemia. Am J Cardiol 1990; 66: 22G–4G.

    Article  PubMed  CAS  Google Scholar 

  19. Willich SN, Pohjola-Sintonen S, Bhatia SJS et al. Suppression of silent ischemia by metoprolol without alteration of morning increase of platelet aggregability in patients with stable coronary artery disease. Circulation 1989; 79: 557–65.

    Article  PubMed  CAS  Google Scholar 

  20. Egstrup K. Attenuation of circadian variation by combined antianginal therapy with suppression of morning and evening increases in transient myocardial ischemia. Am Heart J 1991; 122: 648–55.

    Article  PubMed  CAS  Google Scholar 

  21. Mulcahy D, Cunningham D, Crean P et al. Circadian variation of total ischaemic burden and its alteration with anti-anginal agents. Lancet 1988; II: 755–9.

    Article  Google Scholar 

  22. Deedwania PC, Carbajal EV, Nelson JR, Hait H. Anti-ischemic effects of atenolol versus nifedipine in patients with coronary artery disease and ambulatory silent ischemia. J Am Coll Cardiol 1991; 17: 963–9.

    Article  PubMed  CAS  Google Scholar 

  23. Kostis JB. Comparison of the duration of action of atenolol and nadolol for treatment of angina pectoris. Am J Cardiol 1988; 62: 1171–5.

    Article  PubMed  CAS  Google Scholar 

  24. Quyyumi AA, Wright C, Mockus L, Fox KM. Effect of partial agonist activity in ß blockers in severe angina pectoris: a double blind comparison of pindolol and atenolol. Br Med J 1984; 289: 951–3.

    Article  CAS  Google Scholar 

  25. Quyyumi AA, Crake T, Wright CM, Mockus LJ, Fox KM. Medical treatment of patients with severe exertional and rest angina: double blind comparison of ß blocker, calcium antagonist, and nitrate. Br Heart J 1987; 57: 505–11.

    Article  PubMed  CAS  Google Scholar 

  26. Bowles MJ, Khurmi NS, O’Hara MJ, Raftery EB. Usefulness of bevantolol for chronic, stable angina pectoris. Am J Cardiol 1986; 58: 28–34.

    Article  Google Scholar 

  27. Benhorin J, Banai S, Model M et al. Circadian variations in ischemic threshold and their relation to the occurrence of ischemic episodes. Circulation 1993; 87: 808–14.

    PubMed  CAS  Google Scholar 

  28. Prager G, Prager W, Honig B. Effect of ß-adrenergic blockade on the circadian rhythm of myocardial ischemia in ambulatory patients with stable angina. J Cardiovasc Pharmacol 1989; 13: 638–43.

    PubMed  CAS  Google Scholar 

  29. Gillis AM, Peters RW, Mitchell LB, Duff HJ, McDonald M, Wyse DG. Effects of left ventricular dysfunction on the circadian variation of ventricular premature complexes in healed myocardial infarction. Am J Cardiol 1992; 69: 1009–14.

    Article  PubMed  CAS  Google Scholar 

  30. Lichtstein E, Morganroth J, Harrist R, Hubble E. for the BHAT Study Group. Effect of propranolol on ventricular arrhythmia. The beta-blocker heart attack trial experience. Circulation 1983; 67: 5–10.

    Google Scholar 

  31. Andrews TC, Fenton T, Toyosaki N et al. Subsets of ambulatory myocardial ischemia based on heart rate activity: circadian distribution and response to anti-ischemic medication. Circulation 1993; 88: 92–100.

    PubMed  CAS  Google Scholar 

  32. Langner B, Lemmer B. Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjects. Eur J Clin Pharmacol 1988; 33: 619–24.

    Article  PubMed  CAS  Google Scholar 

  33. Semenowicz-Siuda K, Markiewicz A, Korczynska-Wardecka J. Circadian bioavailability and some effects of propranolol in healthy subjects and liver cirrhosis. Int J Clin Pharmacol Ther Toxicol 1984; 22: 653–8.

    PubMed  CAS  Google Scholar 

  34. Koopmans R, Oosterhuis B, Karemaker JM, Werner J, van Boxtel CJ. The effect of Oxprenolol dosage time on its pharmacokinetics and haemodynamic effects during exercise in man. Eur J Clin Pharmacol 1993; 44: 171–6.

    Article  PubMed  CAS  Google Scholar 

  35. Joy M, Pollard CM, Nunan TO. Diurnal variation in exercise responses in angina pectoris. Br Heart J 1982; 48: 156–60.

    Article  PubMed  CAS  Google Scholar 

  36. Yasue H, Omote S, Takizawa A, Nagao M, Miwa K, Tanaka S. Circadian variation of exercise capacity in patients with Prinzmetal’s variant angina: role of exercise-induced coronary arterial spasm. Circulation 1979; 59: 938–48.

    PubMed  CAS  Google Scholar 

  37. Nesto RW, Phillips RT, Kett KG, McAuliffe LS, Roberts M, Hegarty P. Effect of nifedipine on total ischemic activity and circadian distribution of myocardial ischemic episodes in angina pectoris. Am J Cardiol 1991; 67: 128–32.

    Article  PubMed  CAS  Google Scholar 

  38. Parmley WW, Nesto RW, Singh BN, Deanfield J, Gottlieb SO, and the N-CAP Study Group. Attenuation of the circadian patterns of myocardial ischemia with nifedipine GITS in patients with chronic stable angina. J Am Coll Cardiol 1992; 19: 1380–9.

    Article  PubMed  CAS  Google Scholar 

  39. Juneau M, Théroux P, Waters D, for the Canadian Multicenter Diltiazem Study Group. Effect of diltiazem slow-release formulation on silent myocardial ischemia in stable coronary artery disease. Am J Cardiol 1992; 69: 30B–5B.

    Article  PubMed  CAS  Google Scholar 

  40. Gould BA, Mann S, Kieso H, Balasubramanian V, Raftery EB. The 24-hour ambulatory blood pressure profile with verapamil. Circulation 1982; 65: 22–7.

    Article  PubMed  CAS  Google Scholar 

  41. Raftery EB. Lacidipine and circadian variation in blood pressure: considerations for therapy. J Cardiovasc Pharmacol 1991; 17(Suppl 4): S20-S6.

    PubMed  Google Scholar 

  42. Carr AA, Bottini PB, Feig P et al. Effectiveness of once-daily monotherapy with a new sustained release calcium antagonist. Am J Cardiol 1992; 69: 28E–32E.

    Article  PubMed  CAS  Google Scholar 

  43. Floras JS. Antihypertensive treatment, myocardial infarction, and nocturnal myocardial ischemia. Lancet 1988; II: 994–6.

    Article  Google Scholar 

  44. Raby KE, Vita JA, Rocco MB et al. Changing vasomotor responses of coronary arteries to nifedipine. Am Heart J 1993; 126: 333–8.

    Article  PubMed  CAS  Google Scholar 

  45. Taylor SH. Amlodipine in post-infarction angina. Cardiology 1992; 80(Suppl 1): 26–30.

    Article  PubMed  Google Scholar 

  46. Deanfield JE for the CAPE investigators. Amlodipine reduces the total ischemic burden of patients with coronary disease: double-blind circadian anti-ischemia program in Europe (CAPE) trial. J Am Coll Cardiol 1994; 23: 710–1.

    Google Scholar 

  47. Lemmer B, Nold G, Behne S, Kaiser R. Chronopharmacokinetics and cardiovascular effects of nifedipine. Chronobiol Int 1991; 8: 485–94.

    Article  PubMed  CAS  Google Scholar 

  48. Hla KK, Latham AN, Henry JA. Influence of time of administration on verapamil pharmacokinetics. Clin Pharmacol Ther 1992; 51: 366–70.

    Article  PubMed  CAS  Google Scholar 

  49. Jespersen CM, Frederiksen M, Fischer Hansen J et al. Circadian variation in the pharmacokinetics of verapamil. Eur J Clin Pharmacol 1989; 37: 613–5.

    PubMed  CAS  Google Scholar 

  50. Hausmann D, Nikutta P, Daniel WG, Hatwig CA, Wenzlaff P, Lichtlen PR. Hochdosierte Einmalgabe Isosorbiddinitrat: Einfluß auf die tageszeitliche Verteilung von transitorischen Myokardischämien bei Patienten mit stabiler Angina pectoris. Z Kardiol 1989; 78: 415–20.

    PubMed  CAS  Google Scholar 

  51. Wortmann A, Bachmann K. Chronotherapy in coronary heart disease: comparison of two nitrate treatments. Chronobiol Int 1991; 8: 399–408.

    Article  PubMed  CAS  Google Scholar 

  52. Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med 1991; 325: 986–90.

    Article  PubMed  CAS  Google Scholar 

  53. Ganzinger U. Influence of isosorbide-5-mononitrate on the circadian rhythm of angina pectoris. Arzneim-Forsch/Drug Res 1992; 42: 307–10.

    CAS  Google Scholar 

  54. Lemmer B, Scheidel B, Stenzhorn G et al. Clinical chronopharmacology of oral nitrates. Z Kardiol 1989; 78(Suppl 2): 61–3.

    PubMed  Google Scholar 

  55. Lemmer B, Scheidel B, Blume H, Becker HJ. Clinical chronopharmacology of oral sustained-release isosorbide-5-mononitrate in healthy subjects. Eur J Clin Pharmacol 1991; 40: 71–5.

    Article  PubMed  CAS  Google Scholar 

  56. Scheidel B, Lemmer B. Chronopharmacology of oral nitrates in healthy subjects. Chronobiol Int 1991; 5: 409–19.

    Article  Google Scholar 

  57. Lewis HD, Davis JW, Archibald DG et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study. N Engl J Med 1983; 309: 396–403.

    Article  PubMed  Google Scholar 

  58. Toiler GH, Brezinski D, Schafer AI et al. Concurrent morning increase in platelet aggreg-ability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med 1987; 316: 1514–8.

    Article  Google Scholar 

  59. Ridker PM, Manson JE, Buring JE, Muller JE, Hennekens CH. Circadian variation of acute myocardial infarction and the effect of low-dose aspirin in a randomized trial of physicians. Circulation 1990; 82: 897–902.

    Article  PubMed  CAS  Google Scholar 

  60. Ogawa H, Yasue H, Oshima S, Okumura K, Matsuyama K, Obata K. Circadian variation of plasma fibrinopeptide A level in patients with variant angina. Circulation 1989; 80: 1617–26.

    Article  PubMed  CAS  Google Scholar 

  61. Fujita M, Araie E, Yamanishi K, Miwa K, Kida M, Nakajima H. Circadian variation in the success rate of intracoronary thrombolysis for acute myocardial infarction. Am J Cardiol 1993; 71: 1369–71.

    Article  PubMed  CAS  Google Scholar 

  62. Decousus HA, Croze M, Levi FA et al. Circadian changes in anticoagulant effect of heparin infused at a constant rate. Br Med J 1985; 290: 341–4.

    Article  CAS  Google Scholar 

  63. Witte K, Weisser K, Neubeck M et al .Cardiovascular effects, pharmacokinetics, and converting enzym inhibition of enalapril after morning versus evening administration. Clin Pharmacol Ther 1993; 54: 177–86.

    Article  PubMed  CAS  Google Scholar 

  64. Bruguerolle B, Bouvenot G, Bartolin R et al. Chronopharmacocinétique de la digoxine chez le sujet de plus de soixante-dix ans. Thérapie 1988; 43: 251–3.

    PubMed  CAS  Google Scholar 

  65. Goo RH, Moore JG, Greenberg E et al. Circadian variation in gastric emptying of meals in humans. Gastroenterology 1987; 93: 515–8.

    PubMed  CAS  Google Scholar 

  66. Lemmer B, Nold G. Circadian changes in estimated hepatic blood flow in healthy subjects. Br J Clin Pharmacol 1991; 32: 627–9.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Björn Lemmer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Klaus Witte
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute for Epidemiology, Social and Preventive Medicine, Humboldt University of Berlin, Klinikum Charité, Berlin, Germany

    Stefan N. Willich

  2. Institute for Prevention of Cardiovascular Disease, Deaconess Hospital, Harvard Medical School, Boston, USA

    James E. Muller

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Kluwer Academic Publishers

About this chapter

Cite this chapter

Lemmer, B., Witte, K. (1996). Chronopharmacological aspects of coronary heart disease. In: Willich, S.N., Muller, J.E. (eds) Triggering of Acute Coronary Syndromes. Developments in Cardiovascular Medicine, vol 170. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1577-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1577-0_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7205-2

  • Online ISBN: 978-94-009-1577-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation