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The relationship between gene density and chromosome banding patterns in mammalian nuclei

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Chromosomes Today

Abstract

Most species of eukaryotes examined so far exhibit some degree of chromosome banding (reviewed in Sumner, 1990). Of all eukaryotes, however, mammalian chromosomes respond to the widest range of banding techniques. Of all mammalian species, humans have been the most widely studied with respect to chromosome banding and physical gene mapping. However, the vast majority of banding patterns demonstrated in humans have also been shown in other mammalian species.

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References

  • Allfrey, V.G. (1980) Molecular aspects of regulation of eukaryotic transcription—nucleosomal proteins and their postsynthetic modification in the control of DNA conformation and template function. In Cell Biology: a Comprehensive Tratise, vol. 3, (eds L. Goldstein and D.M. Prestcott), Academic Press, New York.

    Google Scholar 

  • Ambros, P.F. and Sumner, A.T. (1987) Correlation of pachytene chromomeres and metaphase bands of human chromosomes, and distinctive properties of telomeric regions. Cytogenetics and Cell Genetics, 44, 223–8.

    Article  PubMed  CAS  Google Scholar 

  • Aparicio, O.M. and Gottschling, D.E. (1994) Overcoming telomeric silencing: a transactivator competes to establish gene expression in a cell cycle-dependent way. Genes and Development, 8, 1133–46.

    Article  PubMed  CAS  Google Scholar 

  • Bernardi, G. (1989). The isochore organisation of the human genome. Annual Review of Genetics, 23, 637–61.

    Article  PubMed  CAS  Google Scholar 

  • Bernardi, G. (1993) The vertebrate genome, isochores and evolution. Molecular Biology and Evolution, 10, 186–204.

    PubMed  CAS  Google Scholar 

  • Bernardi, G., Olofsson, B., Filipski, J. et al. (1985) The mosaic genome of warm blooded vertebrates. Science, 228, 953–8.

    Article  PubMed  CAS  Google Scholar 

  • Bickmore, W.A. and Bird, A.P. (1992) The use of restriction endonucleases to detect and isolate genes from mammalian cells, in Methods in Enzymology, vol. 216 (ed R Wu), Academic Press, San Diego, pp 224–45.

    Google Scholar 

  • Bird, A.P. (1986) CpG-rich islands and the function of DNA methylation. Nature, 321, 209–13.

    Article  PubMed  CAS  Google Scholar 

  • Bird A., Taggart M., Frommer M. et al. (1985) A fraction of the mouse genome that is derived from islands of nonmethylated CpG-rich DNA. Cell, 40, 91–9.

    Article  PubMed  CAS  Google Scholar 

  • Breneman J.W., Yau P., Teplitz R.L. and Bradbury E.M. (1993) A light microscope study of linker histone distribution in rat metaphase chromosomes and interphase nuclei. Experimental Cell Research, 206, 16–26.

    Article  PubMed  CAS  Google Scholar 

  • Camargo, M. and Cervenka, J. (1982). Patterns of DNA replication of human chromosomes. II. Replication map and replication model. America Journal of Human Genetics, 34, 757–80.

    CAS  Google Scholar 

  • Comings, D.E. (1978). Mechanisms of chromosome banding and implications for chromosome structure. Annual Review of Genetics, 12, 25–46.

    Article  PubMed  CAS  Google Scholar 

  • Craig, J.M. (1995) The functional significance of mammalian chromosome banding. PhD thesis, University of Edinburgh.

    Google Scholar 

  • Craig, J.M. and Bickmore, W.A. (1993) Chromosome bands — flavours to savour. BioEssays, 15, 349–54.

    Article  PubMed  CAS  Google Scholar 

  • Craig, J.M. and Bickmore, W.A. (1994) The distribution of CpG islands in mammalian chromosomes. Nature Genetics, 7, 376–82.

    Article  PubMed  CAS  Google Scholar 

  • Drouin, R. and Richer, C.-L. (1988). High resolution R banding R banding at the 1250-band level II. Schematic representation and nomenclature of human RBG-banded chromosomes. Genome, 32, 425–39.

    Article  Google Scholar 

  • Drouin, R., Lemieux, N. and Richer, C.-L. (1991). Chromosome condensation from prophase to late metaphase: Relationship to chromosome bands and their replication time. Cytogenetics and Cell Genetics, 57, 91–9.

    Article  PubMed  CAS  Google Scholar 

  • Dutrillaux, B. (1973) Nouveau systeme de marquage chromosomique des bandes T. Chromosoma 41, 395–402.

    Article  PubMed  CAS  Google Scholar 

  • Dutrillaux, B., Couturier, J., Richer, C-L. and Viegas-Péguinot, E. (1976). Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment. Chromosoma, 58, 51–61.

    Article  PubMed  CAS  Google Scholar 

  • Egel, R. (1984) 2 tightly linked silent cassettes in the mating-type region of Scizosaccharomyces pombe. Current Genetics, 8, 199–203.

    Article  Google Scholar 

  • Ferguson, B.M. and Fangman, W.L. (1992) A position effect on the time of replication origin activation in yeast. Cell, 68, 333–9.

    Article  PubMed  CAS  Google Scholar 

  • Fernández, J.L., Pereira, S., Campos, A. et al. (1994) An extra band within the human 9qh+ region that behaves like the surrounding constitutive heterochromatin. Journal of Medical Genetics, 31, 632–634.

    Article  PubMed  Google Scholar 

  • Francke, U. (1994) Digitised and differentially shaded human chromosome ideograms for genomic applications. Cytogenetics and Cell Genetics, 65, 206–19.

    Article  PubMed  CAS  Google Scholar 

  • Ganner, E. and Evans, H.J. (1971) The relationship between patterns of DNA replication and of quinacrine fluorescence in the human chromosome complement. Chromosoma, 35, 326–41.

    Article  PubMed  CAS  Google Scholar 

  • Giacalone, J., Freides, J. and Franke, U. (1992). A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes. Nature Genetics, 1, 137–43.

    Article  PubMed  CAS  Google Scholar 

  • Grant, S.G. and Chapman, V.M. (1988) Mechanisms of X chromosome regulation. Annual Review of Genetics, 22, 199–233.

    Article  PubMed  CAS  Google Scholar 

  • Gross, D.S. and Garrard, W.T. (1988) Nuclease hypersensitive sites in chromatin. Annual Review of Biochemistry, 57, 159–97.

    Article  PubMed  CAS  Google Scholar 

  • Hebbes, T.R., Thorne A.W. and Crane-Robinson C. (1988) A direct link between core histone acetylation and transcriptionally active chromatin. EMBO Journal, 7, 1395–402.

    PubMed  CAS  Google Scholar 

  • Holmquist, G.P. (1992). Chromosome bands, their chromatin flavors, and their functional features. American Journal of Human Genetics, 51, 17–37.

    PubMed  CAS  Google Scholar 

  • Hsieh, C-L. and Lieber, M.R. (1992). CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication. EMBO Journal, 11, 315–25.

    PubMed  CAS  Google Scholar 

  • ISCN (1985): An International System for Human Cytogenetic Nomenclature, (eds Harnden, D.G. and Klinger, H.P.), pp. 48–57. Published in collaboration with Cytogenetics and Cell Genetics (Karger, Basel 1985).

    Google Scholar 

  • Jeppesen, P. and Turner, B.M. (1993) The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenetic marker for gene expression. Cell, 74, 281–9.

    Article  PubMed  CAS  Google Scholar 

  • Keshet, L, Lieman-Hurwitz, J. and Cedar, H. (1986) DNA methylation affects the formation of active chromatin. Cell, 44, 535–43.

    Article  PubMed  CAS  Google Scholar 

  • Korenberg, J.R. and Engels, W.R. (1978) Base ratio DNA content and quinacrine brightness of human chromosomes. Proceedings of the National Academy of Science U.S.A., 75, 3382–6.

    Article  CAS  Google Scholar 

  • Larsen, F., Gundersen, G., Lopez, R. and Prydz, H. (1992). CpG islands as gene markers in the human genome. Genomics, 13, 1095–107.

    Article  PubMed  CAS  Google Scholar 

  • Mouchiroud, D., D’Onofrio, G., Aïssani, B., et al. (1991). The distribution of genes in the human genome. Gene, 100, 181–7.

    Article  PubMed  CAS  Google Scholar 

  • Nasir J., Maconochie M.K. and Brown S.D.M. (1991). Co-amplification of L1 line elements with localised low copy repeats in Giemsa dark bands: implications for genome organisation. Nucleic Acids Research, 19, 3255–60.

    Article  PubMed  CAS  Google Scholar 

  • Nickoloff J.A. (1992). Transcription enhances intrachromosomal homologous recombination in mammalian cells. Molecular and Cell Biology, 12, 5311–8.

    CAS  Google Scholar 

  • Nishioka Y., Dolan B.M., Fiorellino A. and Prado V.F. (1992). Nucleotide sequence analysis of a mouse Y chromosomal DNA fragment containing BKM and LINE elements. Genetica, 87, 7–15.

    Article  PubMed  CAS  Google Scholar 

  • Okada T.A. and Comings D.E. (1974). Mechanisms of chromosome banding. III. Similarities between G-bands of mitotic chromosomes and chromomeres of meiotic chromosomes. Chromosoma, 48, 65–71.

    Article  PubMed  CAS  Google Scholar 

  • Oliver S.G., Van der Aart Q.J.M., Agostini-Carbone M.L. et al. (1992) The complete DNA sequence of yeast chromosome III. Nature, 357, 38–46.

    Article  PubMed  CAS  Google Scholar 

  • Riggs A.D. and Pfeifer G.P. (1992). X-chromosome inactivation and cell memory. Trends in Genetics, 8, 169–74.

    PubMed  CAS  Google Scholar 

  • Saccone S., De Sario A., Della Valle G. and Bernardi G. (1992). The highest gene concentrations in the human genome are in T bands of metaphase chromosomes. Proceedings of the National Academy of Science U.S.A., 89, 4923–17.

    Article  Google Scholar 

  • Saccone S., De Sario A., Wiegant J., et al. (1993) Correlations between isochores and chromosomal bands in the human genome. Proceedings of the National Academy of Science U.S.A., 90, 11929–33.

    Article  CAS  Google Scholar 

  • Sumner A.T. (1990) Chromosome Banding, Unwin Hyman, London.

    Google Scholar 

  • Tazi J. and Bird A. (1990) Alternative chromatin structure at CpG islands. Cell, 60, 909–20.

    Article  PubMed  CAS  Google Scholar 

  • Turner B.M. (1991) Histone acetylation and control of gene expression. Journal of Cell Science, 99, 13–20.

    PubMed  CAS  Google Scholar 

  • Verma, R.S., Luke, S., Brennan, J.P. et al. (1993) Molecular topography of the secondary constriction region (qh) of human chromosome 9 with an unusual euchromatic band. American Journal of Human Genetics, 52, 981–986.

    PubMed  CAS  Google Scholar 

  • Wu T-.C. and Lichten M. (1994) Meiosis-induced double-strand break sites determined by yeast chromatin structure. Science, 263, 515–8.

    Article  PubMed  CAS  Google Scholar 

  • Yunis J.J. and Tsai M.Y. (1978). Mapping of polysomal messenger RNA and heterogeneous nuclear RNA to the lightly staining G-bands of human chromosomes. Cytogenetics and Cell Genetics, 22, 364–7.

    Article  PubMed  CAS  Google Scholar 

  • Yunis J.J., Tien Kuo M. and Saunders G.F. (1977) Localisation of sequences specifying messenger RNA to light-staining G-bands of human chromosomes. Chromosoma, 61, 355–44.

    Article  Google Scholar 

  • Yunis, J.J. (1981) Mid prophase human chromosomes. The attainment of 2000 bands. Human Genetics, 56, 293–8.

    Article  PubMed  CAS  Google Scholar 

  • Yunis, J.J. (1981) Mid prophase human chromosomes. The attainment of 2000 bands. Chromosoma, 61, 335–44.

    Article  Google Scholar 

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Authors
  1. J. M. Craig
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  2. W. A. Bickmore
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Editor information

Editors and Affiliations

  1. Department of Genetics, University of San Pablo, Madrid, Spain

    N. Henriques-Gil

  2. The University of Cambridge, UK

    J. S. Parker (Professor of Plant Cytogenetics) (Professor of Plant Cytogenetics)

  3. Department of Genetics, University of Complutense, Madrid, Spain

    M. J. Puertas

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© 1997 The Organizing Committee of the 12th International Chromosome Conference, Madrid, Spain

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Craig, J.M., Bickmore, W.A. (1997). The relationship between gene density and chromosome banding patterns in mammalian nuclei. In: Henriques-Gil, N., Parker, J.S., Puertas, M.J. (eds) Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1537-4_5

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  • DOI: https://doi.org/10.1007/978-94-009-1537-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7186-4

  • Online ISBN: 978-94-009-1537-4

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