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Mast Cells, Mediators and Disease pp 195–226Cite as

Stimulus-Secretion Coupling in Mast Cells and Basophils

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Part of the book series: Immunology and Medicine Series ((IMME,volume 7))

Abstract

Secretory granules are an outstanding feature of mast cell and basophil morphology, and their mediator contents represent major products of the cellular biosynthetic machinery. For example, human lung mast cell tryptase and rat mast cell neutral proteases constitute > 20% of total cell protein1–3. An optimal secretory stimulus is capable of releasing > 60% of the total granule contents, and yet this secretory event may have been initiated by the bridging of only several hundred to a thousand IgE-receptors at the cell surface4. The mechanism whereby a very small stimulus acting at the cell periphery is translated into the fusion of granules with each other and the plasma membrane with the resulting secretion of mediators is termed stimulus-secretion coupling.

References

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  1. R. C. Benyon
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Editors and Affiliations

  1. Immunopharmacology Group, Clinical Pharmacology, University of Southampton, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

  2. Faculty of Medicine, Level D, Centre Block, Southampton General Hospital, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

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Benyon, R.C. (1988). Stimulus-Secretion Coupling in Mast Cells and Basophils. In: Holgate, S.T. (eds) Mast Cells, Mediators and Disease. Immunology and Medicine Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1287-8_7

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  • DOI: https://doi.org/10.1007/978-94-009-1287-8_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7072-0

  • Online ISBN: 978-94-009-1287-8

  • eBook Packages: Springer Book Archive

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