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Modulation of Mast Cell Mediator Secretion by Drugs used in the Treatment of Allergic Diseases

  • Chapter
Mast Cells, Mediators and Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 7))

Abstract

Mast cells are pivotally involved in many diseases with an allergic basis, e.g. asthma and urticaria. In human airways, mast cells constitute 0.5% of the cells lining the bronchi1 where they are ideally situated to interact with inhaled allergens. Evidence for mast cell activation, at least in allergen provocation experiments, derives from the detection of elevated mast cell mediators in bronchoalveolar lavage fluid2 and in blood plasma3,4. Similarly, provocation of urticarial reactions with allergen5 or non-immunological stimuli6–9 is associated with a local elevation of mast cell mediators. The possible therapeutic benefit of drugs which inhibit mast cell mediator release would, therefore, appear to be great. This chapter describes the effects on mast cells of drugs used in the treatment of allergic diseases.

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  1. M. K. Church
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Editors and Affiliations

  1. Immunopharmacology Group, Clinical Pharmacology, University of Southampton, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

  2. Faculty of Medicine, Level D, Centre Block, Southampton General Hospital, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

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Church, M.K. (1988). Modulation of Mast Cell Mediator Secretion by Drugs used in the Treatment of Allergic Diseases. In: Holgate, S.T. (eds) Mast Cells, Mediators and Disease. Immunology and Medicine Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1287-8_10

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