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Phylogeny and Ontogeny of Basophils, Mast Cells and Eosinophils

  • Chapter
Mast Cells, Mediators and Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 7))

Abstract

It has been traditionally assumed that basophils, eosinophils and neutrophils are derived from a common, myeloid bone marrow progenitor, by analogy to erythroid and megakaryocytic lineages. However, the hypothesis of a fixed, common granulocyte progenitor, present in the bone marrow and giving rise to all lineages of granulated (myeloid) cells, has only been partly supported by in vivo and in vitro observations.

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  1. J. A. Denburg
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Editors and Affiliations

  1. Immunopharmacology Group, Clinical Pharmacology, University of Southampton, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

  2. Faculty of Medicine, Level D, Centre Block, Southampton General Hospital, Southampton, SO9 4XY, UK

    S. T. Holgate (MRC Clinical Reasearch Professor of Immunopharmacology) (MRC Clinical Reasearch Professor of Immunopharmacology)

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Denburg, J.A. (1988). Phylogeny and Ontogeny of Basophils, Mast Cells and Eosinophils. In: Holgate, S.T. (eds) Mast Cells, Mediators and Disease. Immunology and Medicine Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1287-8_1

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