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Neutrophil and Complement Defects: Recent Advances

  • Chapter
Immunodeficiency and Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 8))

Abstract

Although a great deal has been learnt about the physiology of phagocytic cells and the complement system from in vitro studies, one cannot necessarily relate such findings to their physiological importance in vivo. It is only by the study of patients with well defined abnormalities of complement or phagocyte function that one can learn how these systems actually function in vivo. Of particular value have been the studies of patients with inherited deficiencies of single proteins. Patients with neutrophil and monocyte abnormalities frequently suffer from recurrent pyogenic infections, those with complement deficiencies develop recurrent infections and also have a high prevalence of immune complex disease. Although patients with inherited deficiencies are extremely rare, nevertheless they have taught us a great deal about the normal biology of both phagocytic cells and the complement system. Such patients represent ‘experiments of nature’ and the frequency with which such individuals are encountered is often inversely related to the impact they have upon our understanding of the biology of phagocytic cells, the complement system and their role in host defence.

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  1. A. Segal
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  2. M. Walport
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  1. Division of Immunological Medicine, Clinical Research Centre, Harrow,Middlesex, UK

    A. D. B. Webster (Consultant Physician and Senior Scientist) (Consultant Physician and Senior Scientist)

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Segal, A., Walport, M. (1988). Neutrophil and Complement Defects: Recent Advances. In: Webster, A.D.B. (eds) Immunodeficiency and Disease. Immunology and Medicine Series, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1275-5_8

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