Abstract
As a result of genetic polymorphism and post-translational glycosylation with sialic acid, apolipoprotein E (apoE), which is distributed mainly between the triglyceride-carrying lipoproteins and the high density lipoproteins (HDL), shows heterogeneity when submitted to isoelectric focusing (Zannis and Breslow, 1981). The three common genetic isoforms of apoE are designated E-4, E-3 and E-2 and contain zero, one and two cysteine residues per molecule, respectively (Weisgraber et al., 1981). These isoforms can be easily separated by isoelectric focusing, but co-migration of sialoforms with the true genetic isoforms complicates the patterns. According to the currently accepted genetic model, three apoE alleles (ε4, ε 3 and ε 2) can occur at a single gene locus, and specify six apoE phenotypes: E4/4, E3/3, E2/2, E4/3, E4/2 and E3/2 (Zannis et al., 1982).
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© 1988 Springer Science+Business Media Dordrecht
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Rawlings, A.V., Deegan, T. (1988). An Erroneous Apolipoprotein E-3 Band in High Density Lipoprotein Fractions. In: Pollitt, R.J., Harkness, R.A., Addison, G.M. (eds) Studies in Inherited Metabolic Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1259-5_13
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DOI: https://doi.org/10.1007/978-94-009-1259-5_13
Publisher Name: Springer, Dordrecht
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