Abstract
Herpes simplex is an enveloped DNA virus able to cause both acute and recurrent diseases in man. There are two types, namely HSV-1 and HSV-2, but the latter is most often associated with genital lesions. The frequency of isolation of HSV-2 from genital episodes varies between investigators and may range from over 90% to as low as 60% 1. It is evident, therefore, that HSV-1 is also a major aetiological agent in genital herpes infections and both types will be considered in this chapter.
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References
Nahmias, A. J., Dannenbarger, J., Wickliffe, C. and Muther, J. (1981). Clinical aspects of infection with herpes simplex virus 1 and 2. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpesviruses. An Interdisciplininary Perspective, pp. 3–9. ( NY: Elsevier Press )
Rawls, W. E. and Campione-Piccardo, J. (1981). Epidemiology of herpes simplex type 1 and 2 infections. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpesviruses. An Interdisciplinary Perspective, pp. 137–152. ( NY: Elsevier Press )
Baringer, J. R. (1981). Latency of herpes simplex and varicella zoster viruses in the nervous system. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpesviruses. An Interdisciplinary Perspective, pp. 202–205. ( NY: Elsevier Press )
Wildy, P., Field, H. J. and Nash, A. A. (1982). Classical herpes latency revisited. In Mahy, B., Minson, A. C. and Darby, G. K. (eds.).Symposium 33, Society for General Microbiology, pp. 133–168. ( NY: Cambridge University Press )
Mims, C. A. (1964). Aspects of the pathogenesis of viral disease.Bacteriol. Rev,28, 30–71
Morahan, P. S., Kern, E. R. and Glasgow, L. A. (1977). Immunomodulator-induced resistance against herpes simplex virus.Proc. Soc. Exp. Biol. Med,154, 615–20
Morahan, P. S., Morse, S. S. and McGeorge, M. E. (1980). Macrophage extrinsic antiviral activity during herpes simplex virus infection.J. Gen. Virol,46, 291–300
Morahan, P. S. (1984). Interactions of herpesviruses with mononuclear phagocytes. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infection, pp. 71–89. ( Florida: CRC Press )
Morahan, P. S., Connor, J. R. and Leary, K. R. (1985). Viruses and the versatile macrophage.Br. Med. Bull,41, 15–21
Bianco, C. and Edelson, P. J. (1978). Plasma membrane expression of macrophage differentiation. In Lerner, R. A. (ed.).Molecular Basis of Cell-Cell Interaction (Birth Defects) vol.14( 2 ), pp. 119–124. ( New York: Alan R. Liss )
Rager-Zisman, B., Kunkel, M., Tanaka, Y. and Bloom, B. R. (1982). Role of macrophage oxidative metabolism in resistance to vesicular stomatitis virus.Infect. Immun,36, 1229–37
Stohlman, S. A., Woodward, J. G. and Frelinger, J. A. (1982). Macrophage antiviral activity: extrinsic versus intrinsic activity.Infect. Immun,36, 672–7
Hayashi, K., Kurata, T., Morishima, T. and Nassery, T. (1980). Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus.Infect. Immun,28. 350 - 8
Wildy, P., Gell, P. G. H., Rhodes, J. and Newton, A. (1982). Inhibition of herpes simplex virus multiplication by activated macrophages: a role for arginase?Infect. Immun,37, 40–5
Johnson, R. T. (1965). The pathogenesis of herpes virus encephalitis II. A cellular basis for the development of resistance with age.J. Exp. Med,120, 359–74
Lopez, C. (1984). Natural resistance mechanisms against herpes virus in health and disease. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infections, pp. 45–70. ( Florida: CRC Press )
Lopez, C. and Dudas, G. (1979). Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice.Infect. Immun,23, 432–7
Armerding, D., Mayer, P., Scriba, M., Hren, A. and Rossiter, H. (1981). In-vivo modulation of macrophage functions by herpes simplex virus type 2 in resistant and sensitive inbred mouse strains.Immunobiology,160, 217 - 27
Mintz, L., Drew, W. L., Hoo, R. and Finley, T. N. (1980). Age-dependent resistance of human alveolar macrophages to herpes simplex virus.Infect. Immun,28, 417–20
Morse, S. S. and Morahan, P. S. (1981). Activated macrophages mediate interferon- independent inhibition of herpes simplex virus.Cell. Immunol,58, 72–84
Stevens, J. G. and Cook, M. L. (1971). Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction.J. Exp. Med,133, 19–38
Rinaldo, C. R., Jr., Richter, B. S., Black, P. H. and Hirsch, M. S. (1979). Persistent infection of human lymphoid and myeloid cell lines with herpes simplex virus.Infect. Immun,25, 521–5
Frank, U., Schindling, B., Lindermann, J. and Falke, D. (1978). Multiplication of herpes simplex virus types 1 and 2 in macrophages of NMRI and C57/BL mice.Acta Virol,22, 193–202
Daniels, C. A., Kleinerman, E. S. and Snyderman, R. (1978). Abortive and productive infections of human mononuclear phagocytes by type 1 herpes simplex virus.Am. J. Pathol,91, 119–29
Johnson, R. B., Jr. (1978). Oxygen metabolism and the microbicidal activity of macrophages.Fed. Proc,37, 2759–64
Sethi, K. K. (1983). Contribution of macrophage arginase in the intrinsic restriction of herpes simplex virus replication in permissive macrophage cultures induced by gamma- interferon containing products of activated spleen cells.Immunobiology,165, 459–74
Stohlman, S. A., Woodward, J. G. and Frelinger, J. A. (1982). Macrophage antiviral activity: extrinsic versus intrinsic activity.Infect. Immun,36, 672–7
Linnavuori, K. and Hovi, T. (1983). Restricted replication of herpes simplex virus in human monocyte cultures: role of interferon. Virology,130, 1–9
Isaacs, A. and Lindenmann, J., (1956). Virus interference. I. The interferons.Proc. R. Soc. Lond. (Ser. B.),147, 258–67
Zawatzky, R., Gresser, I., DeMaeyer, E. and Kirchner, H. (1982). The role of interferon in the resistance of C57BL/6 mice to various doses of herpes simplex virus type 1.J. Infect. Dis,146, 405–10
Gresser, I., Tovey, M. G., Maury, C. and Bandu, M.-T. (1976). Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. II. Studies with herpes simplex virus, Maloney sarcoma, vesicular stomatitis, Newcastle disease and influenza viruses.J. Exp. Med,144, 1316–23
Hirt, H. M., Becker, H. and Kirchner, H. (1978). Induction of interferon production in mouse spleen cell cultures by Corynebacteriumparvum. Cell. Immunol.,38, 168–75
Barinskii, I. F., Popova, O. M., Konstantinova, I. V., Grebeniuk, V. N. and Kuznetsov, V. P. (1985). Indices of alpha-interferon and of lymphocyte natural killer activity in genital herpes and the effect on them of specific vaccination therapy and interferon therapy.Vopr. Virusol,30, 340–3
Panet, A., Gloger, I. and Falk, H. (1985). Mechanisms of herpes simplex virus inhibition by interferon. In Kirchner, H. and Schellekens, H. (eds.).The Biology of the Interferon System 1984, pp. 325–331. (Elsevier Science Publishers)
Haller, O. and Wigzell, H. (1977). Suppression of natural killer cell activity with radioactive strontium: effector cells are marrow dependent.J. Immunol,118, 1503–6
Lopez, C. (1978). Immunological nature of genetic resistance of mice to herpes simplex virus-type 1 infection. In de The, G., Henle, W. and Rapp, F. (eds.).Oncogenesis and Herpes Viruses, Vol.3, pp. 775–81. ( Lyon: WHO )
Schneweis, K. E., Olbrick, M., Saffig, V. and Scholz, R. (1982). Effects of genetic resistance against herpes simplex virus in vaginally infected mice.Med. Microbiol. Immunol,171, 161–9
Armerding, D., Simon, M. M., Hammerling, G. J. and Rossiter, H. (1981). Function, target cell preference and cell surface characteristics of herpes simplex virus type 2 induced non- antigen specific killer cells.Immunobiology,158, 347–68
El-Daher, N. and Betts, R. F. (1985). New observations regarding killing of fibroblasts infected with herpes simplex virus: co-operation between elutable factor and peripheral mononuclear cells.J. Inf. Dis,152, 1197–205
Rouse, B. T. and Lopez, C. (1984). Strategies for immune intervention against herpes simplex virus. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infections, pp. 145–155. ( Florida: CRC Press )
Gidlund, M. Orn, A., Wigzell, H., Senik, A. and Gresser, I. (1978). Enhanced NK cell activity in mice injected with interferon and interferon inducers.Nature(Lond.),273, 759–61
Djeu, J. Y., Heinbaugh, J. A., Holden, H. T. and Herberman, R. B. (1979). Augmentation of mouse natural killer cell activity by interferon inducers.J. Immunol,122, 175–81
Ullberg, M. and Jondal, M. (1981). Recycling and target-binding capacity of human natural killer cells.J. Exp. Med, 153, 615–28
Kohl, S., Loo, L. S., Schmalstieg, F. S. and Anderson, D. C. (1986). The genetic deficiency of leukocyte surface glycoprotein Mac-1, LFA-1, p150, 95 in humans is associated with defective antibody dependent cellular cytotoxicity in vitro and defective protection against herpes-simplex virus infection in vivo.J. Immunol,137, 1688–94
Borysiewicz, L. K., Graham, S. and Sissons, J. G. (1986). Human natural killer cell lysis of virus-infected cells. Relationship to expression of the transferrin receptor.Eur. J. Immunol,16, 405–11
Hall, M. J. and Katrak, K. (1986). The quest for a herpes simplex virus vaccine: background and recent developments.Vaccine,4, 138–50
Shore, S. L. and Feorino, P. M. (1981). Immunology of primary herpes virus infections in humans. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpesviruses. An Interdisciplinary Perspective, pp. 267–288. ( NY: Elsevier Pres )
Norrild, B., Emmertsen, H., Krebs, H. J. and Pedersen, B. (1984). Antibody-dependent immune mechanisms and herpes simplex virus infections. In Rouse, B. T., and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infection, pp. 91–105. ( Florida: CRC Press )
Sundquist, V. A., Linde, A. and Wahren, B. (1984). Virus-specific immunoglobin G subclasses in herpes simplex and varicella-zoster virus infections.J. Clin. Microbiol,20, 94–8
Bernstein, D. I., Lovett, M. A. and Bryson, Y. J. (1984). Serological analysis of first-episode non-primary genital herpes simplex virus infection. Presence of type 2 antibody in acute serum samples.Am. J. Med,77, 1055–60
Devillechabrolle, A., Hugnes-Dorin, F., Fortier, B., Catalan, F. and Huraux, J. M. (1985). Prevelance of serum antibodies to herpes simplex virus types 1 and 2: application of an ELISA technique to 100 cases of anogenital herpes.Sex Transm. Dis,12, 40–3
Courtney, R. J. (1984). Virus-specific components of herpes simplex virus involved in the immune response. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infection, pp. 33–44. ( Florida: CRC Press )
Balachandran, N., Bacchetti, S. and Rawls, W. E. (1982). Protection against lethal challenge of BALB/c mice by passive transfer of monoclonal antibodies to five glycoproteins of herpes simplex virus type 2.Infect. Immun,37, 1132–7
Roberts, P. L., Duncan, B. E., Raybould, T. J. G. and Watson, D. H. (1985). Purification of Herpes virus glycoproteins B and C using monoclonal antibodies and their ability to protect mice against lethal challenge - hybridoma generation, monoclonal antibody production and vaccine purification.J. Gen. Virol,66, 1073–85
Lee, F. K., Coleman, R. M., Pereira, L., Bailey, P. D., Tatsuno, M. and Nahmias, A. J. (1985). Detection of herpes simplex virus type 2-specific antibody with glycoprotein G.J. Clin. Microbiol,22, 641–4
Eberle, R., Mou, S. W. and Zaia, J. A. (1984). Polypeptide specificity of the early antibody response following primary and recurrent genital herpes simplex virus type 2 infections.J. Gen. Virol,65, 1839–43
Eberle, R., Mou, S. W. and Zaia, J. A. (1985). The immune response to herpes simplex virus: comparison of the specificity and relative titres of serum antibodies directed against viral polypeptides following primary herpes simplex type 1 infections.J. Med. Virol,16, 147–62
Ashley, R., Benedetti, J. and Corey, L. (1985). Humoral immune response to HSV-1 and HSV-2 viral proteins in patients with primary genital herpes.J. Med. Virol,17, 153 - 66
Lum, L. G., Orcutt-Thordarson, N. and Seigneuret, M. C. (1985). Regulatory roles of human OKT4/ OKT8 subsets in polyclonal immunoglobulin production induced by herpes simplex type 1 virus.Immunobiology,169, 319–29
McDermott, M. R., Smiley, J. R., Leslie, P., Brais, J., Rudzroga, H. E. and Bienenstock, J. (1984). Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex type 2.J. Virol,51, 747–53
Merriman, H., Woods, S., Winter, C., Fahnlander, A. and Corey, L. (1984). Secretory IgA antibody in cervicovaginal secretions from women with genital infection due to herpes simplex virus.Inf. Dis,149, 505–10
Lagace-Simard, J., Portnoy, J. D. and Wainberg, M. A. (1986). High levels of IgE in patients suffering from frequent recurrent herpes simplex lesions. J. Allergy Clin. Immunol.,77, 582 - 5
Pass, R. F., Whitley, R. J., Whelchel, J. D., Diethelm, A. G., Reynolds, D. W. and Alford, C. (1980). Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation.J. Inf. Dis,140, 487–92
Kohl, S. (1984). The immune response of the neonate to herpes simplex virus infection. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infections, pp. 121–130. ( Florida: CRC Press )
Kohl, and Loo, L. S. (1982). Protection of neonatal mice against herpes simplex virus infection. Probable in vivo antibody-dependent cellular cytotoxicity. J. Immunol.,129, 370–6
Gonik, B., Loo, L. S., Bigelow, R. and Kohl, S. (1985). Influence of menstrual cycle variations on natural killer cytotoxicity and antibody dependent cellular cytotoxicity to cells infected with herpes simplex virus.J. Reprod. Med,30, 493–6
Gonik, B., Loo, L. S., Bigelow, R. and Kohl, S. (1984). Influence of naproxen therapy on natural killer cytotoxicity and antibody-dependent cellular cytotoxicity against cells infected with herpes simplex virus.J. Reprod. Med,29, 722–6
Oldstone, M. B. A. (1981). Lysis of human cells infected with a variety of RNA and DNA viruses is dependent on the alternative complement pathway and specific divalent antibody. In, Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpes Viruses. An Interdisciplinary Perspective, pp. 326–29. ( NY: Elsevier Press )
Smiley, M. L., Hoxie, J. A. and Friedman, H. M. (1985). Herpes simplex virus type 1 infection of endothelial, epithelial and fibroblast cells induces a receptor for C3b.J. Immunol,134, 2673–8
Rouse, B. T. (1984). Cell-mediated immune mechanisms. In Rouse, B. T. and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infections, pp. 107–120. ( Florida: CRC Press )
Schmid, D. S., Larson, H. and Rouse, B. T. (1981). The role of accessory cells and T-cell growth factor in induction of cytotoxic T-lymphocytes against herpes simplex virus antigens.Immunology,44, 755–63
Ferrar, W. L., Johnson, H. M. and Ferrar, J. J. (1981). Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2.J. Immunol,126, 1120–5
Schmid, D. S., Larsen, H. S. and Rouse, B. T. (1982). Role of la antigen expression and secretory function of accessory cells in induction of cytotoxic T lymphocyte responses against herpes simplex virus.Infect. Immun,37, 1138–47
Yasukawa, M. and Zarling, J. M. (1985). Human cytotoxic T-cell clones directed against herpes simplex virus infected cells. Ill Analysis of viral glycoproteins recognised by CTL clones by using recombinant herpes simplex virus.J. Immunol,134, 2679–82
Zarling, J. M., Moran, P. A., Burke, R. L., Pachl, C., Berman, P. W. and Lasky, L. A. (1986). Human cytotoxic T-cell clones directed against herpes simplex virus-infected cells. IV. Recognition and activation by cloned glycoproteins gB and gD.J. Immunol,136, 4669–73
Yasukawa, M. and Zarling, J. M. (1984). Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. I. Lysis restricted by HLA class II MB and DR antigens.J. Immunol,133, 422–7
Wainberg, M. A., Portnoy, J. D., Clecner, B., Hubschman, S., Lagace-Simard, J., Rabinovitch, N., Remer, Z. and Mendelson, J. (1985). Viral inhibition of lymphocyte proliferation responsiveness in patients suffering from recurrent lesions caused by herpes simplex virus.J. Inf. Dis,152, 441–8
Andervont, H. B. (1929). Activity of herpetic virus in mice. J. Infect. Dis.,44, 383–93
Nahmias, A. J. and Visintine, A. M. (1976). Herpes simplex. In Remington, J. S. and Klein, J. O. (eds.).Infectious Diseases of the Foetus and Newborn Infant, p. 156. ( Philadelphia: W. B. Saunders )
Yeager, A. S., Arvin, A. M., Urbani, L. J. and Kemp, L. A. (1980). Relationship of antibody to outcome in neonatal herpes simplex virus infection.Infect. Immun,29, 532–8
Whitley, R. J., Nahmias, A. J., Visintine, A. M., Fleming, C. L. and Alford, C. A. (1980). The natural history of herpes simplex virus infections of mother and newborn.Pediatrics,66, 489–94
Sullender, W. M., Miller, J. L., Yasukawa, L. L., Bradley, J. S., Black, S. B., Yeager, A. S., and Arvin, A. M. (1987). Humoral and cell mediated immunity in neonates with herpes simplex virus infection.J. Inf. Dis,155, 28–37
Hayward, A., Herberger, M. and Corey, L. (1986). IgG subclass of anti-HSV antibodies following neonatal HSV infections.Eur. J. Pediatr,145, 250–1
Baron, S., Georgiades, J. and Worthington, M. (1981). Potential for post exposure prophylaxis of neonatal herpes using passive antibody. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.). The Human Herpesviruses.An Interdisciplinary Perspective, pp. 491–495. ( NY: Elsevier Press )
Pass, R. F., Dworsky, M. E., Whitley, R. J., August, A. M., Stagno, S. and Alford, C. A., Jr. (1981). Specific lymphocyte blastogenic responses in children with cytomegalovirus and herpes simplex virus infections acquired early in infancy.Infect. Immun,34, 166–70
Leibson, P. J., Hunter-Laszlo, M., Douvas, G. S. and Hayward, A. R. (1986). Impaired neonatal natural killer-cell activity to herpes simplex virus: decreased inhibition of viral replication and altered response to lymphokines.J. Clin. Immunol,6, 216–24
Frazier, J. P., Kohl, S., Pickering, L. K. and Loo, L. S. (1982). The effect of route of delivery on neonatal natural killer cytotoxicity and antibody-dependent cellular cytotoxicity to herpes simplex virus-infected cells.Pediatr. Res,16, 558–60
Miller, M. E. (1978). Host Defences in the Human Neonate. ( NY: Grune and Stratton )
Blyth, W. A. and Hill, T. J. (1984). Establishment, maintenance and control of herpes simplex virus latency. In Rouse, B. T., and Lopez, C. (eds.).Immunobiology of Herpes Simplex Virus Infection, pp. 10–32. ( Florida: CRC Press )
Klein, R. J. (1985). Initiation and maintenance of latent herpes virus infections: the paradox of perpetual immobility and continuous movement.Rev. Inf. Dis,7, 21–30
Openshaw, H., Tsuyoshi, S., Wohlenberg, C. and Notkins, A. L. (1981). The role of immunity in latency and reactivation of herpes simplex virus. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.).The Human Herpesviruses. An Interdisciplinary Perspective, pp. 289–296. ( NY: Elsevier Press )
Yasumoto, S., Okabe, N. and Mori, R. (1986). Role of epidermal Langerhans cells in resistance to herpes simplex virus infection.Arch. Virol,90, 261–71
Wrzos, H. and Rapp, H. (1985). Experimental model for activation of genital herpes simplex virus. J. Inf. Dis.,151, 349–54
Scriba, M. (1976). Recurrent genital herpes simplex virus (HSV) infection in guinea pigs.Med. Microbiol Immunol, 162, 201–8
Baker, D. A. and Thomas, J. (1985). The effect of prostaglandin E2 on the initial immune response to herpes simplex virus infection.Am. J. Obstet. Gynecol,151, 586–90
Merigan, T. C. (1981). Immunosuppression and herpes viruses. In Nahmias, A. J., Dowdle, W. R. and Schinazi, R. F. (eds.). The Human Herpesviruses.An Interdisciplinary Perspective, pp. 309–316. ( NY: Elsevier Press )
Sheridan, J. F., Beck, M., Aurelian, L. and Radowsky, M. (1985). Immunity to herpes simplex virus: virus reactivation modulates lymphokine activity.J. Inf. Dis,152, 449–56
Rola-Pleszczynski, M. and Lieu, H. (1984). Natural cytotoxic cell activity linked to time of recurrence of herpes labialis.Clin. Exp. Immunol,55, 224–8
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Hall, M.J., Jeffries, D.J. (1988). Immunobiology of Sexually Transmitted Disease: Herpes Simplex Virus. In: Wright, D.J.M. (eds) Immunology of Sexually Transmitted Diseases. Immunology and Medicine, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1255-7_8
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