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Bile Acids in Health and Disease pp 301–306Cite as

Gallbladder Retention of 75 SeHCAT

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Abstract

75Se homocholic acid taurine (SeHCAT) is a synthetic gamma labelled bile acid that best fulfils the criteria of a substance suitable for investigating distal ileal function in man1. SeHCAT is exclusively absorbed by the active transport site in the terminal ileum2, since its pK is lower than the physiological intestinal pH and since it is poorly deconjugated by the intestinal bacteria. It is then resecreted in bile.

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References

  1. Fromm, H., Thomas, P J. and Hofmann, A.F. (1973). Sensitivity and specificity in tests of distal ileal function: prospective comparison of bile acid and vitamin B12 absorption in ileal resection patients. Gastroenterology, 64, 1077–90

    PubMed  CAS  Google Scholar 

  2. Ferraris, R., Jazrawi, R. and Northfield, T.C. (1984). Bile acid kinetics using a new gamma labelled bile acid. Clin Sci, 66, 12p

    Google Scholar 

  3. Van Blankenstein, M., Van Den Berg, J.W.O., de Groot, R. and Delhez, H. (1981). Radioisotopes in testing ileal function. Br. J. Radiol., 54, 702

    Article  Google Scholar 

  4. Thaysen, E.H., Orholm, M., Arnfred, T., Carl, J. and Rodbro, P. (1982). Assessment of ileal function by abdominal counting of the retention of a gamma emitting bile acid analogue. Gut, 23, 862–5

    Article  PubMed  CAS  Google Scholar 

  5. Nyhlin, H., Merrick, M.V., Eastwood, M.A. and Brydon, W.G. (1983). Evaluation of ileal function using 23-selena-25-homotaurocholate, a gamma labelled conjugated bile acid. Initial clinical assessment. Gastroenterology, 84, 63–8

    PubMed  CAS  Google Scholar 

  6. Dehlez, H., Van Den Berg, J.W.O., Van Blankenstein, M. and Maarwaldt, J.H. (1982). New method for the determination of bile acid turnover using 75-SeHCAT. Eur. J. Nucl Med., 7, 269–71

    Google Scholar 

  7. Ferraris, R., Jazrawi, R., Bridges, C. and Northfield, T.C. (1986). Use of a gamma labelled bile acid (75-SeHCAT) as a test of ileal function. Methods of improving accuracy. Gastroenterology, 90, 1129–36

    PubMed  CAS  Google Scholar 

  8. Northfield, T.C., Jazrawi, R. and Galatola, G. (1986). Behaviour of the gamma labelled bile acid 75-SeHCAT in the enterohepatic circulation in man. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 6–11 (Masson Press)

    Google Scholar 

  9. Jazrawi, R., Lanzini, A., Britten, A., Meller, S.T. and Northfield, T.C. (1984). Dynamics of gallbladder function and of enterohepatic circulation studies by labelled bile acid. Clin. Sci., 66, 10P

    Google Scholar 

  10. Jazrawi, R., Kupfer, R.M., Bridges, C., Joseph, A.E. and Northfield, T.C. (1983). Assessment of gallbladder storage function in man. Clin. Sci., 65, 185–91

    PubMed  CAS  Google Scholar 

  11. Jazrawi, R.P., Ferraris, R., Bridges, C. and Northfield, T.C. (1988). Kinetics for the synthetic bile acid 75SeHCAT in man: Comparison with 14C-taurocholate. Gastroenterology (In press)

    Google Scholar 

  12. Ferraris, R. (1986). 75-SeHCAT gallbladder retention in ileal dysfunction and diarrhoea. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenteroloy, pp. 41–44 (Masson Press)

    Google Scholar 

  13. Lindstedt, S. (1957). The turnover of cholic acid in man. Acta Physiol. Scand., 40, 1–9

    Article  PubMed  Google Scholar 

  14. Ferraris, R., Jazrawi, R., Bridges, C. and Northfield, T.C. (1985). Bile acid turnover using SeHCAT. In Barbara, L., Dowling, R.H., Hofmann, A.F., Roda, E. (eds) Recent Advances in Bile Acid Research, pp. 81–82. (New York: Raven Press)

    Google Scholar 

  15. Sciarretta, G., Vicini, G., Fagioli, G, Verri, A., Ginevra, A. and Malaguti, P. (1986). Use of 23-Selena-25-homocholyl taurine to detect bile acid malabsorption in patients with ileal dysfunction or diarrhoea. Gastroenterology, 91, 1–9

    PubMed  CAS  Google Scholar 

  16. Jazrawi, R., Ferraris, R. and Northfield, T.C. (1986). Daily ileal absorption efficiency for 75-SeHCAT in ileal dysfunction and diarrhoea. In Malaguti, P. and Sciarretta, G. (eds)New Radioisotope Tests in Gastroenterology, pp. 33–40 (Masson Press)

    Google Scholar 

  17. Low-Beer, T.S., Heaton, K.W., Heaton, S.T. and Read, A.E. (1971). Gallbladder inertia and sluggish enterohepatic circulation of bile salts in coeliac disease. Lancet, 1, 991–94

    Article  PubMed  CAS  Google Scholar 

  18. Ferraris, R., Colombatti, G., Fiorentini, M.T., Arossa, W. and De La Pierre, M. (1983). Diagnostic value of serum bile acids and routine liver function tests in hepatobiliary diseases; sensitivity, specificity and predictive value. Dig. Dis. Sci., 28, 129–36

    Article  PubMed  CAS  Google Scholar 

  19. Merrick, M.V., Eastwood, M.A. and Ford, M J. (1985). Is bile acid malabsorption underdiagnosed? An evaluation of accuracy of diagnosis by measurment of SeHCAT retention. Br. Med. J., 290, 665–8

    Article  CAS  Google Scholar 

  20. Hardison, W.G. (1986). Technology illuminates a shadowy syndrome. Gastroenterology, 91, 242–9

    PubMed  CAS  Google Scholar 

  21. De La Pierre, M., Barlotta, A., Ferraris, R. and Rolfo, P. (1986). 14C-Xylose breath test. In Malaguti, P. and Sciarretta, G. (eds). New Radioisotope Tests in Gastroenterology, pp. 62–5 (Masson Press)

    Google Scholar 

  22. Merrick, M.V. (1986). The clinical value of the SeHCAT retention test. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 14–19 (Masson Press)

    Google Scholar 

  23. Centi Colella, A., Liberatore, M., Scopinaro, F. and Valentini, G.L. (1986). Changes of 75SeHCAT whole body retention (WBR) induced by alcohol. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 20–1 (Masson Press)

    Google Scholar 

  24. Bagni, B., Pazzi, P., Putinati, S., Feggi, L.M., Prandini, N. and Trotta, F. (1986). Diagnostic value of 75SeHCAT abdominal retention in detecting malabsorption in detecting malabsorption with systemic sclerosis.In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 31–2

    Google Scholar 

  25. Fiorentini, M.T., Locatelli, L., Ceccopieri, B., Bertolino, F., Ostellino, O., Barlotta, A., Rolfo, P., Ferraris, R., De La Pierre, M. and Dellepiane, M. (1987). Physiology of ileoanal anastomosis with ileal reservoir for ulcerative colitis and adenomatosis coli. Dis Colon Rectum, 30, 267–72

    Article  PubMed  CAS  Google Scholar 

  26. Bracco, E., Argiro, G., Antonacci, P., Castellano, G., Podio, V. and Sategna-Guidetti, C. (1986). Assessment of ileal function by 75SeHCAT retention test. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 27–8 (Masson Press)

    Google Scholar 

  27. Hofmann, A. (1986). Bile acid absorption and malabsorption: state of the art. In Malaguti, P. and Sciarretta, G. (eds) New Radioisotope Tests in Gastroenterology, pp. 3–5(Masson Press)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Gastroenterology, Ospedale Mauriziano, Torino, Italy

    R. Ferraris

  2. Department of Medicine, St. Grorge’s Hospital Medical School, SW170RE, London, UK

    R. Ferraris

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  1. R. Ferraris
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Editor information

Editors and Affiliations

  1. Department of Medicine, St. George’s Hospital Medical School, London, UK

    Tim Northfield , Riadh Jazrawi  & Patrick Zentler-Munro ,  & 

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© 1988 Kluwer Academic Publishers

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Ferraris, R. (1988). Gallbladder Retention of 75 SeHCAT. In: Northfield, T., Jazrawi, R., Zentler-Munro, P. (eds) Bile Acids in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1249-6_24

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  • DOI: https://doi.org/10.1007/978-94-009-1249-6_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7054-6

  • Online ISBN: 978-94-009-1249-6

  • eBook Packages: Springer Book Archive

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