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Metallo-Organic Complexes and Carcinogenesis

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Part of the book series: Topics in Molecular Organization and Engineering ((MOOE,volume 4))

Abstract

In cancer research, two kinds of methods are currently practised. In the first series, chemicals or radiations are administered to animals or humans and after a while, a body count helps to establish the statistics of the disease or the cure rate and the effectiveness of a therapy (Figure 1). We call these the ‘black box methods’. In the other manner, people try to get to know what could happen inside the black box by examining the disease at the molecular scale.

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References

  1. J. Lascombe and P. V. Huong, Eds.: Raman Spectroscopy, Linear and Non-Linear, Wiley, New York (1982).

    Google Scholar 

  2. P.V. Huong: ‘Chemical Applications of Resonance Raman Spectroscopy’, in Vibrational Spectra and Structure, J.R. During, Ed., Elsevier, Amsterdam (1980).

    Google Scholar 

  3. P.V. Huong: ‘New Analytical Possibilities of Raman and Resonance Raman Spectroscopy’, in Reviews on Analytical Chemistry, L. Niinisto, Akademia Kiado, Budapest (1982).

    Google Scholar 

  4. P.V. Huong, E. Audry, R. Giege, D. Moras, J.C. Thierry, and M.B. Comarmond: ‘Conformationchangeinyeast-transfer-Ribonucleic-Acid Aspartate’. Biopolymers 23, 71(1984).

    Article  CAS  Google Scholar 

  5. P.V. Huong: ‘Drug Analysis by Raman and Micro-Raman Spectroscopy’. J. of Pharmaceutical and Biomedical Analysis 4, 811(1986).

    Article  CAS  Google Scholar 

  6. N. Vanbac, C. Moisand, A. Gouyette, G. Muzard, N. Datxuong, J. B. le Pecq, and C. Paoletti: ‘Metabolism and disposition studies of ellipticinesin animals’. Cancer Treatment Reports 64, 879 (1980).

    CAS  Google Scholar 

  7. P.V. Huong and S.R. Plouvier: ‘Blue particles in cancerous organs studied by Laser Micro-Raman Spectroscopy’. J. Mol. Structure 115, 489 (1984).

    Article  CAS  Google Scholar 

  8. S.R. Plouvier and P.V. Huong: ‘Microbial chromophore materials in circulating blood identified by Laser Micro-Raman Spectroscopy’. Biorheology, Suppl.I, 345 (1984).

    Google Scholar 

  9. R. Giege, P.V. Huong, and D. Moras: ‘Molecular dynamics in t-RNA. Crystallographic and Raman spectroscopic evidences’. Spectrochim. Acta 42A, 378(1986).

    Google Scholar 

  10. P. Carmona, P.V. Huong, and E. Gredilla: ‘Raman spectroscopic study of the binding of copper to nucleotides’, in Raman Spectroscopy, W. Peticolas and B. Hudson, Eds. (1986), p.2/15.

    Google Scholar 

  11. P.V. Huong, S.R. Plouvier, and P. Lambert: ‘Complexes organométalliques dans les tissus cancéreux’, in Spectroscopy of Biomolecules, Alix, Bernard, Manfait, Eds., New York (1985), p.946.

    Google Scholar 

  12. J. Lorosch, W. Haase, and P.V. Huong: ‘Resonance Raman spectroscopic investigations on phenolate-bridged binuclear Cu complexes: a basis for the identification of the endogenous bridging ligand in hemocyanin’. J. Inorg. Biochemistry 27, 53 (1986).

    Article  Google Scholar 

  13. P.V. Huong, P. Carmona, and J. Lorosch: ‘Metalloproteins and metallo-nucleotides’, in Raman Spectroscopy, W. Peticolas and B. Hudson, Eds. (1986), p.4/3.

    Google Scholar 

  14. P.V. Huong and J.C. Cornut: ‘Theinterconversionofthezwitterionanduncharged form of γ-amino-butyricacid (GABA)’. J. Chem. Phys. 65, 4748 (1976).

    Article  CAS  Google Scholar 

  15. M. Avignon, P.V. Huong, J. Lascombe, M. Marraud, and J. Neel: ‘Etude par spectroscopie infrarouge de la conformation de quelques composés peptidique smodèles’. Biopolymers 8, 69 (1969).

    Article  CAS  Google Scholar 

  16. M. Avignon and P.V. Huong: ‘Une méthode de dosage des isomères de rotation des dipeptides en solution par spectroscopic infrarouge’. Biopolymers 9, 427 (1970).

    Article  CAS  Google Scholar 

  17. M. Marraud, J. Neel, M. Avignon, and P.V. Huong: ‘Contribution à l’étude conformationnelle des composés peptidiques en solution’. J. Chim. Phys. 67, 959 (1970).

    CAS  Google Scholar 

  18. E. Frieden: ‘New perspectives on the essential trace elements’. J. Chem. Education 62, 917 (1985).

    Article  CAS  Google Scholar 

  19. F.W. Sunderman: ‘Mechanisms of Metal Carcinogenesis’, in The Clinical Biochemistry of Cancer, M. Fleisher Ed., AACC, Washington D.C. (1979).

    Google Scholar 

  20. W.A. Creasey: Cancer, Oxford University Press (1981).

    Google Scholar 

  21. K.D. Karlin and J. Zubieta, Eds.: Biological and Inorganic Copper Chemistry. Adenine Press, Guilderland N.Y. (1986).

    Google Scholar 

  22. P.V. Huong and J.C. Pommier: ‘Une relation entrefréquences Raman de résonance et rayondu coeur de cycle de smétalloporphyrines’. Compt. Rend. Acad. Sci. 285C, 519 (1977).

    Google Scholar 

  23. U. Mioc, P.V. Huong, and H. Ledon: ‘Effect of dimerization on the structure of molybdenium tetraphenylporphyrin’. J. Mol. Structure 142, 481 (1986).

    Article  CAS  Google Scholar 

  24. M. J. Murray and C. P. Flessel: ’Metal-polynucleotide interactions. A comparison of carcinogenic and non-carcinogenic metals in vitro’. Biochim. Biophys. Acta 425, 256 (1976).

    CAS  Google Scholar 

  25. Y. P. Blagoi, U. A. Sorokin, V. A. Valew, and G. O. Gladchenko: ‘Characteristics of the helix- coil transition in DNA in the region of GC and AT base-pairs. Relative stability inversion due to Cu2+ and Mn2+’. Dokl. Akad. Nauk. SSSR 240, 459 (1978).

    CAS  Google Scholar 

  26. L. A. Loeb, M. A. Sirover, and S. S. Agarwal: ‘Infidelity of DNA synthesis as related to mutagenesis and carcinogenesis’, in Inorganic and Nutritional Aspects of Cancer, G. N. Schrauzer, Ed., Plenum Press, New York (1978), p. 103.

    Google Scholar 

  27. J. W. Thompson and C. Voegtlin: ‘Glutathione content of normal animals’. J. Biol. Chem. 70, 793(1926).

    CAS  Google Scholar 

  28. P. V. Huong and S. P. Plouvier: in Molecular Structure and Spectra, J. R. Durig, Ed., Elsevier, Amsterdam (1988).

    Google Scholar 

  29. A. M. Novi: ‘Regression of Alflatoxin Bj Induced Hepatocellular Carcinomas by Reduced Glutathione’. Science 212, 541 (1981).

    Article  CAS  Google Scholar 

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© 1989 Kluwer Academic Publishers, Dordrecht, The Netherlands.

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Huong, P.V. (1989). Metallo-Organic Complexes and Carcinogenesis. In: Maruani, J. (eds) Molecules in Physics, Chemistry, and Biology. Topics in Molecular Organization and Engineering, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1173-4_6

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  • DOI: https://doi.org/10.1007/978-94-009-1173-4_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-90-277-2599-8

  • Online ISBN: 978-94-009-1173-4

  • eBook Packages: Springer Book Archive

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