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Microbial Synthesis of Vitamin B1 (Thiamine)

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Biotechnology of Vitamins, Pigments and Growth Factors

Part of the book series: Elsevier Applied Biotechnology Series ((APBISE))

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Abstract

Thiamine was discovered in the course of a search for an agent that would cure beriberi. The conquest of beriberi began in 1885 when Takaki (1885) practically eradicated the disease among the Japanese navy by introducing fish, vegetables, meat and barley into the diet. In 1897 Eijkman (1897) showed that an experimental polyneuritis in fowl, which closely resembled the polyneuritic symptoms of beriberi, could be produced by feeding the birds on a diet of polished rice. When they were fed on unpolished rice they did not develop the disease. In 1926 Jansen & Donath (1926) isolated a crystalline hydrochloride of the antineuritic factor from rice bran.

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Authors and Affiliations

  1. Department of Biochemistry, Kyoto Prefectural University of Medicine, Kyoto, Japan

    A. Iwashima

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  1. A. Iwashima
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Editors and Affiliations

  1. Laboratory of General and Industrial Microbiology, State University of Ghent, Belgium

    Erick J. Vandamme

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© 1989 Elsevier Science Publishers Ltd

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Iwashima, A. (1989). Microbial Synthesis of Vitamin B1 (Thiamine). In: Vandamme, E.J. (eds) Biotechnology of Vitamins, Pigments and Growth Factors. Elsevier Applied Biotechnology Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1111-6_9

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  • DOI: https://doi.org/10.1007/978-94-009-1111-6_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6991-5

  • Online ISBN: 978-94-009-1111-6

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