Skip to main content

Part of the book series: Elsevier Applied Biotechnology Series ((APBISE))

Abstract

Humans,like most other animals, need carotenoids but cannot synthesize them. Our main suppliers are the fruits and vegetables, with lesser, mostly indirect contributions from fungi, algae, and bacteria. Carotenoid production is rarely the main objective of a culture, but colourful products rich in carotenoids are obtained from various plants and algae. The oldest example is saffron (Crocus sativus), still planted in La Mancha, Spain, and elsewhere for the stigmas of its flowers. Many fields of central Mexico become bright orange in the summer with the flowers of cempasúchil (Tagetes tenuifolia, a kind of marigold), whose dried petals are fed to chicken for meat and egg yolk colour. Annatto is extracted from the seeds of a tropical tree, Bixa orellana. The most familiar carotenoid-rich product is probably paprika, a powder made by grinding red peppers (Capsicum annuum).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alvarez, M. I. & Eslava, A. P. (1983). Isogenic strains of Phycomyces blakesleeanus suitable for genetic analysis. Genetics, 105, 873–9.

    CAS  Google Scholar 

  • Anderson, R. F., Arnold, M., Nelson, G. E. N. & Ciegler, A. (1958). Microbiological production of beta-carotene in shaken flasks. J. Agric. Food Chem., 6, 543–5.

    Article  CAS  Google Scholar 

  • Andrewes, A. G. & Starr, M. P. (1976). (3R, 3’R)-Astaxanthin from the yeast Phaffia rhodozyma. Phytochem., 15, 1009–11.

    Article  CAS  Google Scholar 

  • Andrewes, A. G., Phaff, H. J. & Starr, M. P. (1976). Carotenoids of Phaffia rhodozyma, a red-pigmented fermenting yeast. Phytochem., 15, 1003–7.

    Article  CAS  Google Scholar 

  • Arnau, J., Murillo, F. J. & Torres-Martinez, S. (1988). Expression of Tn5-derived kanamycin resistance in the fungus Phycomyces blakesleeanus. Molec. Gen. Genet.,212, 375–7.

    Article  CAS  Google Scholar 

  • Austin, D. J., Bu’Lock, J. D. & Drake, D. (1970). The biosynthesis of trisporic acids from beta-carotene via retinal and trisporol. Experientia, 26, 348–9.

    Article  CAS  Google Scholar 

  • Avalos, J. & Cerdá-Olmedo, E. (1986). Chemical modification of carotenogenesis in Gibberella fujikuroi. Phytochem., 25, 1837–41.

    Article  CAS  Google Scholar 

  • Avalos, J. & Cerdá-Olmedo, E. (1987). Carotenoid mutants of Gibberella fujikuroi. Curr. Genet., 11, 505–11.

    Article  CAS  Google Scholar 

  • Barnett, H. L., Lilly, V. G. & Krause, R. F. (1956). Increased production of carotene by mixed + and — cultures of Choanephora cucurbitarum. Science, 123, 141.

    Article  CAS  Google Scholar 

  • Bauernfeind, J. C. (Ed.) (1981). Carotenoids as Colorants and Vitamin A Precursors. Technological and Nutritional Applications. Academic Press, New York.

    Google Scholar 

  • Bejarano, E. R. & Cerdá-Olmedo, E. (1989). Inhibition of phytoene dehydrogenation and activation of carotenogenesis in Phycomyces. Phytochem., 28, 1623–6.

    Article  CAS  Google Scholar 

  • Bejarano E. R., Govind, N. S. & Cerdá-Olmedo, E. (1987). Zeta-carotene and other carotenes in a Phycomyces mutant. Phytochem., 26, 2251–4.

    Article  CAS  Google Scholar 

  • Bejarano, E. R., Parra, F., Murillo, F. J. & Cerdá-Olmedo, E. (1988). End-product regulation of carotenogenesis in Phycornyces. Archs Microbiol., 150, 209–14.

    Article  CAS  Google Scholar 

  • Bergman, K., Eslava, A. P. & Cerdá-Olmedo, E. (1973). Mutants of Phy corny ces with abnormal phototropism. Molec. Gen. Genet., 123, 1–16.

    Article  CAS  Google Scholar 

  • Bindl, E., Lang, W. & Rau, W. (1970). Untersuchungen über die lichtabhängige Carotinoidsynthese. VI. Zeitlicher Verlauf der Synthese der einzelnen Carotenoide bei Fusarium aquaeductuum under verschiedenen Induktionsbedingungen. Planta, 94, 156–74.

    Article  CAS  Google Scholar 

  • Blakeslee, A. F. (1904). Sexual reproduction in the Mucorineae. Proc. Am. Acad. Arts Sei., 40, 205–319.

    Article  Google Scholar 

  • Bramley, P. M. & Mackenzie, A. (1988). The regulation of carotenoid biosynthesis. Curr. Topics Cell Regul., 29, 291–343.

    CAS  Google Scholar 

  • Burgeff, H. (1924). Untersuchungen über Sexualität und Parasitismus bei Mucorineen. Botan. Abhandl., 4, 1–135.

    Google Scholar 

  • Caglioti, L., Cainelli, G., Camerino, B., Mondelli, R., Prieto, A., Quilico, A., Salvatori, T. & Selva, A. (1966). The structure of trisporic-C acid. Tetrahedron Suppl., 7, 175–87.

    Article  Google Scholar 

  • Castillo, R. (1980). On the transformation of beta-carotene 15,15′-3H2 into astaxanthin by the hermit crab Clinabarius erythropus Latreille (1818), Crustacea, Decapoda, Anomoura. Comp. Biochem. Physiol., 66A, 695–7.

    Article  CAS  Google Scholar 

  • Cerdá-Olmedo, E. (1985). Carotene mutants of Phycornyces. Meth. Enzymol., 110, 220–43.

    Article  Google Scholar 

  • Cerdá-Olmedo E. (1987). Carotene. In Phycomyces, ed. E. Cerdá-Olmedo & E. D. Lipson. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 199–222.

    Google Scholar 

  • Cerdá-Olmedo, E. & Hüttermann, A. (1986). Förderung und Hemmung der Carotin-synthese bei Phycomyces durch Aromaten. Angew. Botanik, 60, 59–70.

    Google Scholar 

  • Cerdá-Olmedo, E. & Lipson, E. D. (Eds) (1987). Phycomyces. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

    Google Scholar 

  • Ciegler, A. (1965). Microbial carotenogenesis. Adv. Appl. Microbiol., 7, 1–34.

    Article  CAS  Google Scholar 

  • Ciegler, A., Arnold, M. & Anderson, R. F. (1959a). Microbiological production of carotenoids. IV. Effect of various grains on production of beta-carotene by mated strains of Blakeslea trispora. Appl. Microbiol., 7, 94–8.

    CAS  Google Scholar 

  • Ciegler, A. Arnold M. & AndersonR. F. (1959b). Microbiological production of carotenoids. V. Effect of lipids and related substances on production of beta-carotene. Appl. Microbiol., 7, 98–101.

    CAS  Google Scholar 

  • Ciegler, A., Nelson, G. E. N. & Hall, H. H. (1962). Microbiological production of carotenoids. VIII. Influence of hydrocarbon on carotenogenesis by mated cultures of Blakeslea trispora. Appl. Microbiol., 10, 132–6.

    CAS  Google Scholar 

  • Ciegler, A., Lagoda, A. A., Sohns, V. E., Hall, H. H. & Jackson, R. W. 1963a. Beta-carotene production in 20-liter fermentors. Biotechnol. Bioengin., 5, 109–21.

    Article  Google Scholar 

  • Ciegler, A., Nelson, G. E. N. & Hall, H. H. (1963b). Enhancement of beta-carotene synthesis by citrus products. Appl. Microbiol., 11, 128–31.

    CAS  Google Scholar 

  • Ciegler, A., Nelson, G. E. N. & Hall, H. H. (1963c). Enhancement of carotenogenesis in Blakeslea trispora by essential citrus oils. Nature, Lond., 198, 1305–6.

    Article  CAS  Google Scholar 

  • Ciegler, A., Pazola, Z. & Hall, H. H. (1964). Stimulation of carotenogenesis by microbial cells. Appl. Microbiol, 12, 150–54.

    CAS  Google Scholar 

  • De la Concha, A. & Murillo, F. J. (1984). Accumulation of a complex form of beta-carotene by Phycomyces blakesleeanus cytoplasmic mutants. Planta, 161,233–9.

    Article  Google Scholar 

  • De la Guardia, M. D., Aragon, C. M. G., Murillo, F. J. & Cerdá-Olmedo, E. (1971). A carotenogenic enzyme aggregate in Phycomyces: Evidence from quantitative complementation. Proc. natn. Acad. Sei. U.S.A., 68, 2012–15.

    Article  Google Scholar 

  • El-Jack, M., Mackenzie, A. & Bramley, P. M. (1988). The photoregulation of carotenoid biosynthesis in Aspergillus giganteus mut. alba. Planta, 174, 59–66.

    CAS  Google Scholar 

  • Engel, B. G., Würsch, J. & Zimmermann, M. (1953). Über den Einfluss von beta-Jonon auf die Bildung von beta-Carotin durch Phycomyces blakesleeanus. Helv. Chim. Acta, 36, 1771–6.

    Article  CAS  Google Scholar 

  • Eslava, A. P.(1987). Genetics.In Phycomyces, ed. E.Cerdá-Olmedo & E. D. Lipson. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 27–48.

    Google Scholar 

  • Eslava, A. P. & Cerdá-Olmedo, E. (1974). Genetic control of phytoene dehydrogena-tion in Phycomyces. Plant Sei. Lett., 2, 9–14.

    Article  CAS  Google Scholar 

  • Eslava, A. P., Alvarez, M. I. & Cerdá-Olmedo, E. (1974). Regulation of carotene biosynthesis in Phycomyces by vitamin A and beta-ionone. Eur. J. Biochem., 48, 617–23.

    Article  CAS  Google Scholar 

  • Feofilova, E. P. (1974). Pigmenty mikroorganizmov. Nauka, Moscow.

    Google Scholar 

  • Feofilova, E. P. & Bekhtereva, M. N. (1976). Effect of vitamin A on carotene biosynthesis by Blakeslea trispora (in Russian). Mikrobiologia, 45, 557–8.

    CAS  Google Scholar 

  • Feofilova, E. P., Ushanova, A. E. & Ivanova, G. B. (1982). Effect of dimilin on carotene production by Blakeslea trispora (in Russian). Mikrobiologia, 51, 267–71.

    CAS  Google Scholar 

  • Garber, E. D., Baird, M. L. & Weiss, L. M. (1978). Genetics of Ustilago violacea. II. Polymorphism of color and nutritional requirements of sporidia from natural populations. Bot. Gaz., 139,261–5.

    Google Scholar 

  • Gogek, C. J. (1968). Stabilization of crude carotene-containing mycelium. J. Agric. Food Chem., 16, 730–34.

    Article  CAS  Google Scholar 

  • Gooday, G. W., Fawcett, P., Green, D. & Shaw, G. (1973). The formation of fungal sporopollenin in the zygospore wall of Mucor mucedo: a role for the sexual carotenogenesis in the Mucorales. J. Gen. Microbiol., 74, 233–9.

    CAS  Google Scholar 

  • Goodwin, T. W. (Ed.) (1976). Chemistry and Biochemistry of Plant Pigments, 2nd edn, two vols. Academic Press, London.

    Google Scholar 

  • Goodwin, T. W.(1980). The Biochemistry of the Carotenoids. 2nd edn., Vol. 1, Plants. Chapman and Hall, London/Academic Press, London.

    Google Scholar 

  • Goodwin, T. W. (1986). Metabolism, nutrition, and function of carotenoids. Ann. Rev. Nutr., 6, 273–397.

    Article  CAS  Google Scholar 

  • Goodwin, T. W. (Ed.) (1988). Plant Pigments. Academic Press, London.

    Google Scholar 

  • Goodwin, T. W. & Griffiths, L. A. (1952). Studies in carotenogenesis. 5. Carotene production by various mutants of Phycomyces blakesleeanus and Phycomyces nitens. Biochem. J., 52, 499–501.

    CAS  Google Scholar 

  • Govind, N. S. & Cerdá-Olmedo, E. (1986). Sexual activation of carotenogenesis in Phycomyces blakesleeanus. J. Gen. Microbiol., 132, 2775–80.

    CAS  Google Scholar 

  • Hanson, A. M. (1967). Production of pigments and vitamins. In Microbial Technology, ed. H. J. Peppier. Van Nostrand-Rheinhold, Princeton, pp. 222–50.

    Google Scholar 

  • Harding, R.W. & Shropshire, W. (1980). Photocontrol of carotenoid biosynthesis. Ann. Rev. Plant Physiol., 31, 217–38

    Article  CAS  Google Scholar 

  • Harding, R.W. & Turner, R. V. (1981). Photo regulation of the carotenoid biosynthetic pathway in albino and white collar mutants of Neurospora crassa. Plant Physiol.,68,745–9.

    Article  CAS  Google Scholar 

  • Harding, R. W., Huang, P. C. & Mitchell, H. K. (1969). Photochemical studies of the carotenoid biosynthetic pathway in Neurospora crassa. Archs Biochem. Biophys., 129, 696–707.

    Article  CAS  Google Scholar 

  • Hsu, W. J., Yokoyama, H. & Coggins, C. W. (1972). Carotenoid biosynthesis in Blakeslea trispora. Phytochem., 11, 2985–90.

    Article  CAS  Google Scholar 

  • Isler, O. (Ed.) (1971). Carotenoids. Birkhäuser Verlag, Basel.

    Google Scholar 

  • Johnson, E. A. & Lewis, M. J. (1979). Astaxanthin formation by the yeast Phaffia rhodozyma. J. Gen. Microbiol, 115, 173–83.

    CAS  Google Scholar 

  • Johnson, E. A., Conklin, D. E. & Lewis, M. J. (1977). The yeast Phaffia rhodozyma as a dietary pigment source for salmonids and crustaceans. J. Fish. Res. Board Can.,34, 2417–21.

    Article  CAS  Google Scholar 

  • Johnson, E. A., Villa, T. G., Lewis, M. J. & Phaff, H. J. (1978). Simple method for isolation of astaxanthin from the basidiomycetous yeast Phaffia rhodozyma. Appl. Environ. Microbiol., 35, 1155–9.

    CAS  Google Scholar 

  • Khabrova, A. M. & Zhdanov, V. G. (1979). Study of sex defective mutants of Blakeslea trispora. Mikrobiologia, 48, 1055–9.

    Google Scholar 

  • Krzeminiski, L. F. & Quackenbush, F. W. (1960). Stimulation of carotene synthesis in submerged cultures of Neurospora crassa by surface-active agents and ammonium nitrate. Archs Biochem. Biophys., 88, 64–7.

    Article  Google Scholar 

  • Lampila, L. E., Wallen, S. E. & Bullerman, L. B. (1985a). A review of factors affecting biosynthesis of carotenoids by the order Mucorales. Mycopathologia, 90,65–80.

    Article  CAS  Google Scholar 

  • Lampila, L. E., Wallen, S. E., Bullerman, L. B. & Lowry, S. R. (1985c). The effect of strain and type of whey on the production of beta-carotene and other parameters. Lebensmittel Wissenschaft-Technologie, 18, 366–9.

    Google Scholar 

  • Lampila, L. E., Wallen, S. E., Bullerman, L. B. & Lowry, S. R. (1985c). The effect of illumination on growth and beta-carotene content of Blakeslea trispora grown in whey. Lebensmittel-Wissenschaft-Technologie, 18, 370–73.

    CAS  Google Scholar 

  • Lilly, V. G., Barnett, H. L. & Krause, R. F. (1960). The production of carotene by Phycomyces blakesleeanus. West Virginia Univ. Agr. Exper. Sta., Bulletin 441T, Morgantown.

    Google Scholar 

  • Mackinney, G., Nakayama, T., Buss, C. D. & Chichester, C. O. (1952). Carotenoid production in Phycomyces. J. Am. Chem. Soc, 74, 3456–7.

    Article  CAS  Google Scholar 

  • Mackinney, G., Nakayama, T., Chichester, C. O. & Buss, C. D. (1953). Biosynthesis of carotene in Phycomyces. J. Am. Chem. Soc, 75, 236–8.

    Article  CAS  Google Scholar 

  • Murillo, F. J. & Cerdá-Olmedo, E. (1976). Regulation of carotene synthesis in Phycomyces. Molec. Gen. Genet., 148, 19–24.

    Article  CAS  Google Scholar 

  • Murillo, F. J., Calderón, I. L., López-Diaz, I. & Cerdá-Olmedo, E. 1978. Carotene-superproducing strains of Phycomyces. Appl. Environ. Microbiol., 36,639–42.

    CAS  Google Scholar 

  • Murillo, F. J., Torres-Martinez, S., Aragon, C. M. G. & Cerdá-Olmedo, E. (1981). Substrate transfer in carotene biosynthesis in Phycomyces. Eur. J. Biochem., 119, 511–16.

    Article  CAS  Google Scholar 

  • Ninet, L. & Renaut, J. (1979). Carotenoids. In Microbial Technology, 2nd edn, Vol. 1, ed. H. J. Peppier & D. Perlman. Academic Press, New York, pp. 529–44.

    Google Scholar 

  • Ninet, L., Renaut, J. & Tissier, R. (1969). Activation of the biosynthesis of carotenoids by Blakeslea trispora. Biotechnol. Bioeng., 11, 1195–210.

    Article  CAS  Google Scholar 

  • Rau, W. (1983). Photoregulation of carotenoid biosynthesis. In Biosynthesis of isoprenoid compounds, ed. J. W. Porter & S. L.Spurgeon. John Wiley, New York, pp. 123–57.

    Google Scholar 

  • Rau W. & Schrott, E. L. (1987). Blue light control of pigment biosynthesis— Carotenoid biosynthesis. In Blue Light Responses, Vol. I, ed. H. Senger. CRC Press, Boca Raton, Florida, pp. 43–63.

    Google Scholar 

  • Reyes, P., Chichester, C. O. & Nakayama, T. O. M. (1964). The mechanism of beta-ionone stimulation of carotenoid and ergosterol biosynthesis in Phycomyces blakesleeanus. Biochim. Biophys. Acta, 90, 578–92.

    CAS  Google Scholar 

  • Roncero, M. I. G. & Cerdá-Olmedo, E. (1982). Genetics of carotene biosynthesis in Phycomyces. Curr. Genet., 5, 5–8.

    Article  CAS  Google Scholar 

  • Suärez, T. & Eslava, A. P. (1988). Transformation of Phycomyces with a bacterial gene for kanamycin resistance. Molec. Gen. Genet., 212, 120–23.

    Article  Google Scholar 

  • Sutter, R. P. (1970). Effect of light on beta-carotene accumulation in Blakeslea trispora. J. Gen. Microbiol., 64, 215–21.

    CAS  Google Scholar 

  • Sutter, R. P. (1975). Mutations affecting sexual development in Phycomyces blakesleeanus. Proc. natn. Acad. Sei. USA, 72, 127–30.

    Article  CAS  Google Scholar 

  • Tada, M. & Shiroishi, M. (1982). Mechanism of photoregulated carotenogenesis in Rhodotorula minuta. I. Photocontrol of carotenoid production. Plant Cell Physiol., 23, 541–7.

    CAS  Google Scholar 

  • Valadon, L. R. G. & Mummery, R. S. (1973). Effect of certain inhibitors of carotenogenesis in Verticillium agaricinum. Microbios, 7, 173–80.

    CAS  Google Scholar 

  • Vaskivnyuk, V. Y. & Getman, E. I. (1984). Biosynthesis of carotenoids in light in continuous cultures of the yeast Rhodosporidium diobovatum (in Russian). Priklad. Biokhim. Mikrobiol., 20, 480–83.

    CAS  Google Scholar 

  • Will, O. H., Ruddat, M., Garber, E. D. & Kezdy, F. J. (1984). Characterization of carotene accumulation in Ustilago violacea using high-performance liquid chromatography. Curr. Microbiol., 10, 57–64.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Elsevier Science Publishers Ltd

About this chapter

Cite this chapter

Cerdá-Olmedo, E. (1989). Production of Carotenoids with Fungi. In: Vandamme, E.J. (eds) Biotechnology of Vitamins, Pigments and Growth Factors. Elsevier Applied Biotechnology Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1111-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1111-6_3

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6991-5

  • Online ISBN: 978-94-009-1111-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics