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Microbial Production of Biotin

  • Chapter
Biotechnology of Vitamins, Pigments and Growth Factors

Part of the book series: Elsevier Applied Biotechnology Series ((APBISE))

Abstract

In 1927, Boas described a skin injury produced in rats by feeding raw egg white, as well as the occurrence in various foodstuffs of a ‘protective factor X’ that prevented and cured this injury (Boas, 1927). György et al. (1939) tracked down this protective factor and called it vitamin H after the German Haut for skin. Kögl & Tönnis (1936) isolated a yeast growth factor, biotin vitamin B8 from egg yolk in the form of its crystalline methyl ester and Kögl (1937) determined its empirical formula. Biotin was later shown to be identical to vitamin H, the protective factor X, and to coenzyme R. Melville et al. (1942) determined the correct structure of biotin, which was later confirmed by total chemical synthesis in the Merck laboratories (Harris et al., 1943, 1944a,b, 1945) and verified by X-ray crystallography (Traub, 1956; Trotter & Hamilton, 1966).

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  1. Department of Agricultural Chemistry, Kyoto University, Kyoto, 606, Japan

    Y. Izumi & H. Yamada

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  1. Y. Izumi
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  2. H. Yamada
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  1. Laboratory of General and Industrial Microbiology, State University of Ghent, Belgium

    Erick J. Vandamme

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© 1989 Elsevier Science Publishers Ltd

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Izumi, Y., Yamada, H. (1989). Microbial Production of Biotin. In: Vandamme, E.J. (eds) Biotechnology of Vitamins, Pigments and Growth Factors. Elsevier Applied Biotechnology Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1111-6_14

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  • DOI: https://doi.org/10.1007/978-94-009-1111-6_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6991-5

  • Online ISBN: 978-94-009-1111-6

  • eBook Packages: Springer Book Archive

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