Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Antitumor Effects of Interferons

  • Chapter
Cancer Management in Man

Part of the book series: Cancer Growth and Progression ((CAGP,volume 10))

  • 162 Accesses

Abstract

Numerous studies have been reported, examining the effects of Interferons (IFNs) on tumors of different type and histology in various animal systems. Both IFNs and IFN inducers have been used to study inhibitory effects on virus, chemical and radiation induced tumors as well as transplantable and spontaneous tumors. These have been reviewed extensively elsewhere (2, 33, 83)

The opinions or assertions contained herein are the private views of the authors and should not be construed as official or necessarily reflecting the views of the Uniformed Services University of the Health Sciences or Department of Defense.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bagloini G: Interferon-induced enzymatic activities and their role in the antiviral state. Cell 17: 255, 1979

    Article  Google Scholar 

  2. Balkwill FR: Antitumor effects of interferons in animals. In: Interferons in vivo and clinical studies, edited by Finter, NB Oldham, RK pp. 23–46. Elsevier, Amsterdam, 1985

    Google Scholar 

  3. Balkwill FR, Taylor-Papadimitriou J: Interferon affects both G, and S + G, in cells stimulated from quiescence to growth. Nature (London) 274: 789, 1978

    Article  Google Scholar 

  4. Balkwill FR, Watling D, Taylor-Papadimitriou J: Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast. Int J Cancer 22: 258, 1978

    Article  PubMed  CAS  Google Scholar 

  5. Billiau A: Sensitivity of oncornavirus-carrier lines to the antiviral and growth inhibitory properties of interferon. In: Proc Symp Clin Use of Interferon. pp. 105–112. Zagreb, Yugoslavia. 1975

    Google Scholar 

  6. Billiau A: Hermans H, Allen PT, DeMaeyer-Guinard J, DeSomer P: Trapping of oncornavirus particles at the surface of Interferon-treated cells. Virology 73:537, 1976

    Article  PubMed  CAS  Google Scholar 

  7. Borecky L, Lackovic V, Waschke K: Immunological implications of interferon production in leukocytes. In: pp. 745–754.

    Google Scholar 

  8. Braun W, Levy HB: Interferon preparations as modifiers of immune responses. Proc Soc Exp Biol Med 141:769, 1972

    PubMed  CAS  Google Scholar 

  9. Brennan MB, Stark GR: Interferon pretreatment inhibits simian virus 40 replication by blocking the onset of early transcription. Cell 33::811, 1983

    Article  PubMed  CAS  Google Scholar 

  10. Brouty-Boye D, Gresser I, Baldwin C: Decreased sensitivity to interferon associated with in vitro transformation of Xray-transformed cells. Int J Cancer 24:261, 1979

    Article  PubMed  CAS  Google Scholar 

  11. Brouty-Boye D, and Tovey MG: Inhibition by interferon of thymidine uptake in chemostat culture of L1210 cells in vitro. Intervirology 9:243, 1977

    Article  CAS  Google Scholar 

  12. Cantell K: Why is interferon not in clinical use today? In: Interferon I (I. Gresser I (ed.). New York, Academic Press, pp. 1–28, 1979

    Google Scholar 

  13. Cerottini JC, Brunner KT, Lindahl P, Gresser I: Inhibitory effect of interferon preparations and inducers on the multiplications of transplanted allogenic spleen cells and syngenic bone marrow cells. Nature New Biol 242::152, 1973

    Google Scholar 

  14. Chang, EH, and Friedman RM: A large glycoprotein of Moloney leukemia virus derived from interferon-treated cells. Biochem Biophys Res Commun 77:392, 1977

    Article  PubMed  CAS  Google Scholar 

  15. Chang EH, Jay FT, Friedman RM: Physical, morphological and biochemical alterations in membranes of AKR cells after interferon treatment. Proc Natl Acad Sci USA 75: 1859, 1978

    Article  PubMed  CAS  Google Scholar 

  16. Chernyakhovskaya IY, Slavina EG, Svet-Moldaysky GJ: Antitumor effect of lymphoid cells activated by interferon. Nature 228:71, 1970

    Article  PubMed  CAS  Google Scholar 

  17. Chirigos MA, Pearson JA: Cure of murine leukemia with drug and interferon treatment. J Natl Cancer Inst 51:1367, 1973

    PubMed  CAS  Google Scholar 

  18. Collyn-d’Hooghe M, Brouty-Boye D, Malaise EP, Gresser I: Interferon and cell division XII prolongation by interferon of the intermitotic time of mouse mammary tumor cells in vitro. Exp Cell Res 105:73, 1977

    Google Scholar 

  19. Crane JL Jr, Glasgow LA, Kerr ER, Youngner JS: Inhibition of murine osteogenic sarcoma by treatment with type I or type II interferon. J Natl Cancer Inst 61:871, 1978

    PubMed  Google Scholar 

  20. Czarniecki CW, Sreevalsan T, Friedman RM, Panet A: Dissociation of interferon effects on murine leukemia virus and encephalomyocarditis in mouse cells J Virol 37:827, 1981

    PubMed  CAS  Google Scholar 

  21. Epstein DA, Czarniecki CW, Jacobsen J, Friedman RM, Panet A: A mouse cell line which is unprotected by interferon against lytic virus infection, lacks ribonuclease F activity. Eur J Biochem 118:9, 1981

    Article  PubMed  CAS  Google Scholar 

  22. Farrell PJ, Broeze RJ, Lengyel P: Accumulation of an mRNA and protein interferon treated Ehrlich ascites cells. Nature 279:523, 1979

    Article  PubMed  CAS  Google Scholar 

  23. Foon KA, Sherwin SA, Abrams PG, Longo DL, Fer MF, Stevenson HC, Ochs JJ, Bottino GC, Schoenberger CS, Zeffren J, Jaffe E, Oldham RK: Treatment of advanced non-Hodgkin’s lymphoma with recombinant leukocyte A interferon. New Engl J Med 311:11–48, 1984

    Article  Google Scholar 

  24. Foon KA, Sherwin SA, Abrams PG, Holmes P, Maluish AE, Oldham RK, Herberman RB: A phase I trial of recombinant gamma interferon in patients with cancer. Ca Immun Immunother, 1985

    Google Scholar 

  25. Frayssinet C, Gresser I, Tovey M., Lindahl P: Inhibitory effect of patent interferon preparations on liver regeneration. Nature (London) 245:146, 1973

    Article  CAS  Google Scholar 

  26. Friedman, RM: Antiviral activities of interferons. Bact Rev 41:543, 1977

    PubMed  CAS  Google Scholar 

  27. Friedman RM: Interferons: interactions with cell surfaces. In: Interferon I Edited by Gresser I, pp. 53–73. Academic Press, New York, 1979

    Google Scholar 

  28. Friedman RM, Chang EH, Ramseur JM, Meyers MW: Interferon-directed inhibition of chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers. J Virol 16:569, 1975

    PubMed  CAS  Google Scholar 

  29. Friedman RM, Pastan I: Interferon and cyclic-3’5’-adenosine monophosphate: potentiation of antiviral activity. Biochem Biophys Res Commun 36:735, 1969

    Article  PubMed  CAS  Google Scholar 

  30. Friedman RM, Ramseur JM: Inhibition of murine leukemia virus production in chronically infected AKR cells: a novel effect of interferon. Proc Natl Acad Sci USA 71:35–42, 1974

    Article  Google Scholar 

  31. Friedman RM, Vogel SN: Interferons with special emphasis on the immune system. Adv in Immunol 34:97, 1983

    Article  CAS  Google Scholar 

  32. Glasgow LA, Crane JL Jr, Kerr ER, Youngner JS: Antitumor activity of interferon against murine osteogenic sarcoma in vivo and in vitro. Cancer Treat Rep 62, 1881, 1978

    CAS  Google Scholar 

  33. Greenberg HB, Pollard RB, Lutwick LI, Gregory PB, Robinson WS, Merigan TC: Human leukocyte interferon and hepatitis B virus infection. New Engl J Med 295:517, 1976

    Article  PubMed  CAS  Google Scholar 

  34. Gresser I: Antitumor effects of interferon. In: Cancer — A Comprehensive treatise, edited by Becker EF, Vol. 5, PP. 521571. Plenum Press, New York, 1977

    Google Scholar 

  35. Gresser I, Bourali C: Exogenous interferon and inducers of interferon in the treatment of Balb/c mice inoculated with RC19 tumor cells. Nature 223:844, 1969

    Article  PubMed  CAS  Google Scholar 

  36. Gresser I, Bourali C: Development of newborn mice during prolonged treatment with interferon. Eur J Cancer 6:553, 1970

    Article  PubMed  CAS  Google Scholar 

  37. Gresser I, Bourali C: Antitumor effects of interferon preparations in mice. J Natl Cancer Inst 45:365, 1970

    PubMed  CAS  Google Scholar 

  38. Gresser I, Bourali C: Inhibition by interferon preparations of a solid malignant tumor & pulmonary metastases in mice. Nature New Bio1 236:78, 1972

    Article  CAS  Google Scholar 

  39. Gresser I and Bouraly-Maury C: Antitumor effect of interferon in lymphocyte and macrophage depressed mice. Proc Soc Exp Biol and Med 144:898, 1973

    Google Scholar 

  40. Gresser I, Bourali C, Levy JP: Increased survival in mice inoculated with tumor cells and treated with interferon preparations. Proc Natl Acad Sci USA 63:51, 1969

    Article  PubMed  CAS  Google Scholar 

  41. Gresser I, De Maeyer-Guignard J, Tovey MG, De Maeyer E: Electrophoretically pure mouse interferon exerts multiple biological effects. Proc Natl Acad Sci USA 76:5308 1979

    Article  PubMed  CAS  Google Scholar 

  42. Gresser I, Maury C, Brouty-Boye D: On the mechanisms of the antitumor effect of interferon in mice. Nature 239:167, 1972

    Article  PubMed  CAS  Google Scholar 

  43. Gresser I, Maury C, Tovey MG: Efficacy of combined interferon-cyclophosphamide therapy after diagnosis of lymphoma in AKR mice. Eur J Cancer 14:97, 1978

    Article  PubMed  CAS  Google Scholar 

  44. Herberman RB, Djeu JY, Ortaldo JR, Holden HT, West WH, Bonnard GD: Role of interferon in augmentation of natural and antibody-dependent cell-mediated cytotoxicity. Cancer Treat Rep 62:1893, 1978

    PubMed  CAS  Google Scholar 

  45. Herberman RB, Ortaldo JR, Bonnard GD: Augmentation by interferon of human natural and antibody mediated cytotoxicity. Nature (London) 277:221, 1979

    Article  CAS  Google Scholar 

  46. Hooks JJ, Moulsopoulos HM, Notkins AL: The role of interferon in immediate hypersensitivity & autoimmune diseases. Ann NY Acad Sci 350:21, 1980

    Article  PubMed  CAS  Google Scholar 

  47. Hovenessian AG, Wood J, Meurs E, Montagnier K: Increased nuclease activity in cells treated with pppA2’p5’A2’p5A. Proc Natl Acad Sci USA 76:3261, 1979

    Article  Google Scholar 

  48. Janne J, Pogo H, and Raina A: Polyamines in rapid growth and cancer. Biochem Biophys Acta 473:241, 1978

    PubMed  CAS  Google Scholar 

  49. Jordan GW, Fried RP, Merigan TC: Administration of human leukocyte interferon in herpes zoster I safety, circulating antiviral activity and host responses to infection. J Infect Dis 130:56, 1974

    Article  PubMed  CAS  Google Scholar 

  50. Kimchi A, Shure H, Revel M: Regulation of lymphocyte mitogenesis by 2’S’-oligoisoadenylate. Nature 282:849, 1979

    Article  PubMed  CAS  Google Scholar 

  51. Knight E Jr, Korant BD: Fibroblast interferon induces synthesis of 4 proteins in human fibroblast cells. Biochem Biophys Res Commun 74:707, 1977

    Article  PubMed  CAS  Google Scholar 

  52. Kohn LD, Friedman RM, Holmes JM, Lee G: Use of thyrotropin and cholera toxin to probe the mechanism by which interferon initiates its antiviral activity. Proc Natl Acad Sci USA 73:3695, 1976

    Article  PubMed  CAS  Google Scholar 

  53. Krause F, Silverman RH, Jacobsen H, Leisy SA, Samid D, Chang EH, Friedman RM: Regulations of ppp(A2’p)mRdependent RNase levels during interferon treatment and cell differentiation. Cur J Biochem 146:611, 1985

    Article  CAS  Google Scholar 

  54. Land H, Parada LF, Weinberg RA: Cellular oncogenes and multistep carcinogenesis. Science 22:771, 1983

    Google Scholar 

  55. Lee E, Sreevalsan T: Interferon as an inhibitor of polyamine enzymes. In: Advances in Polyamine Research, Vol. III, edited by Vincenzo Zappia. Raven Press, New York, 1981

    Google Scholar 

  56. Lindahl P, Leary P, Gresser I: Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes. Proc Natl Acad Sci USA 69:721, 1972

    Article  PubMed  CAS  Google Scholar 

  57. Lindahl P, Leary P, Gresser I: Enhancement by interferon of the exression of cell surface antigens on murine leukemia L1210 cells. Proc Natl Acad Sci USA 70:2785, 1973

    Article  PubMed  CAS  Google Scholar 

  58. Meldolesi MT, Friedman RM, Kohn LD: An interferon-induced increase in cyclic AMP precedes the establishment of the antiviral state. Biochem Biophys Res Commun 79:239, 1977

    Article  PubMed  CAS  Google Scholar 

  59. Merigan TC, Sikora K, Breeden JH, Levy R, Rosenberg SA: Preliminary observations on the effect of human leukocyte interferon on non-Hodgkin’s lymphoma. New Engl J Med 299:1449, 1978

    Article  PubMed  CAS  Google Scholar 

  60. Metz DH, Levin MJ, Oxman MN: Mechanism of interferon action: further evidence for transcription as the primary site of action in SV40 infection. J Gen Virol 32:227, 1976

    Article  PubMed  CAS  Google Scholar 

  61. Miller Z, Lovelace E, Gallo M, Pastan I: Cyclic guanosine monophosphate and cellular growth. Science 190:1213, 1975

    Article  PubMed  CAS  Google Scholar 

  62. Naso RB, Yeong-Huei CW, Edbauer CA: Antiretroviral effect of interferon: proposed mechanism. J Interferon Res 2:75, 1982

    Article  PubMed  CAS  Google Scholar 

  63. Oldham RK, Smalley RV: The role of interferon in the treatment of cancer. In: Interferon: Research, Clinical,Application, and Regulatory Consideration edited by Zoon KC, Noguchi PC, Lui TY, pp. 191–205. Elsevier Science Publishing, 1984

    Google Scholar 

  64. Oldham RK: Biologicals and biological response modifiers: The fourth modality of cancer treatment. Cancer Treat Rep 68:221, 1984

    PubMed  CAS  Google Scholar 

  65. Oldham RK: Biologicals and biological response modifiers: New strategies for clinical trials. In: Interferons, IV, edited by Finter NB., Oldham RK, pp. 235–249. Elsevier Science Publishers B.V. 1985

    Google Scholar 

  66. Oldham RK: Interferon: A model for future biologicals. In: Interferon VI,edited by Burke D, Cantell K, Gresser I, DeMaeyer E, Landy M, Revel A, Vilcek J, pp. 127–143. Academic Press, 1985

    Google Scholar 

  67. Oldham RK: Biologicals for cancer treatment: Interferons. Hospital Practice, December, 1985

    Google Scholar 

  68. Oldham RK: Biological response modifiers, In: Biological Response Modifiers, edited by Torrence PF. Academic Press, 1985

    Google Scholar 

  69. Oxman MM, Rowe WP, and Black PH: Studies of adenovirus-SV40 hybrids VI differential effects of interferon on SV40 virus, adenovirus and adenovirus-SV40 hybrids viruses. Proc Natl Acad Sci USA 57:941, 1967

    Article  PubMed  CAS  Google Scholar 

  70. Panet A, Czarniecki CW, Falk H, Friedman RM: Effect of 2’5’-oligoadenylic acid on a mouse cell line partially resistant to interferon. Virology 114:567, 1981

    Article  PubMed  CAS  Google Scholar 

  71. Paucker K, Cantell K, Henle W: Quantitative studies on viral interference in suspended L-cells. III Effect of interfering viruses and interferon on the growth rate of cells. Virology 17:324, 1962

    Article  PubMed  CAS  Google Scholar 

  72. Pitha PM, Fernie B, Maldarelli F, Hattman T, Wivel NA: Effect of interferon on mouse leukemia virus (MuLV) V. Abnormal proteins in virions of Rauscher MuLV produced in the presence of interferon. J Gen Virol 46:97, 1980

    Article  PubMed  CAS  Google Scholar 

  73. Pitha PM, Rowe WP, Oxman MM: Effect of interferons on exogenous, endogenous and chronic murine leukemia virus infection. Virology 70:324, 1976

    Article  PubMed  CAS  Google Scholar 

  74. Revel M: Molecular mechanisms involved in the antiviral effects of interferon. In: Interferon I’ edited by Gresser I, pp. 101–163. Academic Press, New York, 1979

    Google Scholar 

  75. Rozengurt E: Synergistic stimulation of DNA synthesis by cyclic AMP derivatives and growth factors in mouse 3T3 cells. In: Surface of Normal and Malignant Cells’ edited by Hynes RO,pp. 323–343. John Wiley, 1979

    Google Scholar 

  76. Salvin SB, Youngner JS, Nishio J, Neta R: Tumor suppression by a lymphokine released into circulation of mice with delayed hypersensitivity. J Natl Cancer Inst 55:1233, 1975

    PubMed  CAS  Google Scholar 

  77. Samid D, Chang EH, Friedman RM: Biochemical correlates of phenotypic reversion in interferon-treated mouse cells transformed by a human oncogene. Biochem Biophys Res Comm 126:509, 1984

    Article  Google Scholar 

  78. Schroeder EW, Chou IN, Jaken S, Black P: Interferon inhibits the release of plasminogen activator from SV3T3 cells. Nature 276:828, 1978

    Article  Google Scholar 

  79. Schultz RM: Macrophage activation by interferons. In: Lymphokine Reports, Vol. I, edited by Pick E. Academic Press, New York, 1980

    Google Scholar 

  80. Sherwin SA, Knost JA, Fein S, Abrams PG, Foon KA, Ochs JJ, Schoenberger C, Maluish AE, Oldham RK: A multiple dose Phase I trial of recombinant leukocyte A interferon in cancer patients. J Am Med Assoc 248:2461, 1982

    Article  CAS  Google Scholar 

  81. Sonnenfeld G: Modulation of immunity by interferon. In: Lymphokine Reports, Vol.l, edited by Pick E. Academic Press, New York, 1980

    Google Scholar 

  82. Sonnenfeld G, Mandel AD, Merigan TC: Time and dosage-dependence of immunoenhancement by murine type II interferon preparation. Cell Immunol 34:193, 1977

    Article  PubMed  CAS  Google Scholar 

  83. Sreevalsan T, Rozengurt E, Taylor-Papadimitriou J, Burch-ell J: Differential effect of interferon on DNA synthesis, 2 deoxyglucose uptake and orithine decarboxylase activity in 3T3 cells stimulated by polypeptide growth factors and tumor promoters. J Cell Physiol 104:1, 1979

    Article  Google Scholar 

  84. Sreevalsan T, Taylor-Papadimitriou J, Rozengurt E: Differential effect of interferon on DNA synthesis, 2 deoxyglucose uptake and ornithine decarboxylase activity in 3T3 cells stimulated by polypeptide growth factors and tumor promoters. J Cell Physiol 104:1, 1980

    Article  PubMed  CAS  Google Scholar 

  85. Stewart II WE: The Interferon System, edited by Stewart H WE, Springer-Verlag. Wien, New York, 1979

    Google Scholar 

  86. Strander H: Interferons: antineoplastic drugs? Blut 35:277, 1977

    Article  PubMed  CAS  Google Scholar 

  87. Strander H, Einhorn S: Effect of human leukocyte interferon on the growth of human osteosarcoma cells in tissue culture. Int J Cancer 19:468, 1977

    Article  PubMed  CAS  Google Scholar 

  88. Svet-Moldaysky GJ, Chernyakhovskaya IY: Interferon and the interactions of allogenic normal and immune lymphocyte with L-cells. Int J Cancer 19:468, 1967

    Google Scholar 

  89. Taylor-Papadimitriou J: Effect of interferons on cell growth and function. Nature 215:1299, 1980

    Google Scholar 

  90. Tovey MG, Rochette-Egly C, Castagna M: Antiviral activity induced by culturing lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer cell activity by interferon and antagonistic inhibition of susceptibility of target cells lysis. Proc Natl Acad Sci USA 76:3890, 1979

    Article  PubMed  CAS  Google Scholar 

  91. Trinchieri G, Santoli D: Retroviruses as mutagens: insertion and excision of a non-transforming provirus alter expression of a resident transforming provirus. J Exp Med 147:1314, 1978

    Article  PubMed  CAS  Google Scholar 

  92. Varmus HE, Quintnell N, Orgiz S: Immunosuppressive effects of lymphocyte (Type II) and leukocyte. Cell 26:23, 1981

    Article  Google Scholar 

  93. Virelizier JL, Chan EL, Allison AC: (Type I) interferon on primary antibody responses in vivo and in vitro. Clin Exp Immunol 30:299, 1977

    CAS  Google Scholar 

  94. Weber JM, Stewart RB: Interaction of interferon with cells: limited heterologous reactivity or chick and mouse interferon. J Gen Virol 28:363, 1975

    Article  PubMed  CAS  Google Scholar 

  95. Williams BRG, Kerr IM: Inhibition of protein synthesis by 2’5’-linked adenine oligonucleotides in intact cells. Nature 282:88, 1978

    Article  Google Scholar 

  96. Wood JN, Hovanessian AG: Interferon enhances 2’-5’ A synthetase in embroyonal carcinoma cells. Nature 282:74, 1979

    Article  PubMed  CAS  Google Scholar 

  97. Yamamoto K, Yamaguchi N, Oda K: Mechanisms of interferon-induced inhibition of early Simian virus 40 (SV0.0) functions. Virology 68:58, 1975

    Article  PubMed  CAS  Google Scholar 

Postscript References

  1. Aune TM: Role and function of antigen nonspecific suppressor factors. CRC Crit Rev Immunol 7(2):93, 1987

    CAS  Google Scholar 

  2. Boiron M: Interferons in hemato-cancerology. Nouv Rev Fr Hematol 291(1):49, 1987

    Google Scholar 

  3. Boiron M: Future developments in interferon therapy. Int J Cancer (Suppl) 1:41, 1987

    Article  CAS  Google Scholar 

  4. Fahey JL, Sarna G, Gale RP, Seeger R: Immune interventions in disease (published erratum appears in Ann Intern Med 1987 106(6):783). Ann Intern Med 106(2):257, 1987

    CAS  Google Scholar 

  5. Fauci AS, Rosenberg SA, Sherwin SA et al: NIH conference. Immunomodulators in clinical medicine. Ann Intern Med 106(3):421, 1987

    PubMed  CAS  Google Scholar 

  6. Figlin RA: Biotherapy with interferon in solid tumors. Oncol Nurs Forum 14(6 Suppl):23, 1987

    PubMed  CAS  Google Scholar 

  7. Goldstein D, Laszlo J: The role of interferon in cancer therapy: a current perspective. CA 38(5):258, 1988

    PubMed  CAS  Google Scholar 

  8. Guillou PJ: Potential impact of immunobiotechnology on cancer therapy. Br J Surg 74(8):705, 1987

    Article  PubMed  CAS  Google Scholar 

  9. Kirchner H: The interferon system as an integral part of the defense system against infections. Antiviral Res 6(1):1, 1986

    Article  PubMed  CAS  Google Scholar 

  10. Kulesh DA, Greene JJ: Shape-dependent regulation of proliferation in normal and malignant human cells and its alteration by interferon. Cancer Res 46(6):2793, 1986

    PubMed  CAS  Google Scholar 

  11. Lindemann A, Oster W, Herrmann F, Mertelsmann R: Cytokines in tumor therapy. Arzneimittelforsch 38(3A):466, 1988

    PubMed  CAS  Google Scholar 

  12. Melchiori A, Allavene G, Bohm J et al: Interference inhibit chemotaxis of transformed cells and their invasion of a reconstituted basement membrane. Anticancer Res 7(3 Pt B):475, 1987

    PubMed  CAS  Google Scholar 

  13. Ohno R: Clinical studies on interferon in cancer therapy in Japan. Gan To Kagaku Ryoho 143(5 Pt 1):1194, 1987

    Google Scholar 

  14. Quesada JR, Talpam M, Rios A et al: Clinical toxicity of interferons in cancer patients: a review. J Clin Oncol 4(2):234, 1986

    PubMed  CAS  Google Scholar 

  15. Rios A, Stringfellow DA, Fitzpatrick Fa et al: Phase I study of 2-amino-5-brorno-6-phenyl-4(3H)-pyrimidinone (ABPP): an oral interferon inducer, in cancer patients. J Biol Response Mod 5(4):330, 1986

    PubMed  CAS  Google Scholar 

  16. Robert KH, Juliusson G, Einhorn S et al: Activation of malignant B-lymphocytes: pathophysiologic and clinical importance. Scand J Haematol 37(5):363, 1986.

    Article  PubMed  CAS  Google Scholar 

  17. Roth MS, Foon KA: Biotherapy with interferon in hematologic malignancies. Oncol Nurs Forum 14(6 Suppl):16, 1987

    PubMed  CAS  Google Scholar 

  18. Sager R: Genetic suppression of tumor formation: a new frontier in cancer research. Cancer Res 46(4 Pt 1):1573, 1986

    PubMed  CAS  Google Scholar 

  19. Satoh M, Inagawa H, Shimada Y et al: Endogenous production of tumor necrosis factor in normal mice and human cancer patients by interferons and other cytokines combined with biological response modifiers of bacterial origin. J Biol Response Mod 6(5):512, 1987

    PubMed  CAS  Google Scholar 

  20. Schneider FJ: The interferon system. A review of biological principles and clinical uses. Z Gesamte Inn Med 41(22):613, 1986

    PubMed  CAS  Google Scholar 

  21. Stahel RA: Current status and perspectives in the treatment of tumor with biological substances. Ther Umsch 45(6):358, 1988

    PubMed  CAS  Google Scholar 

  22. Stanton GJ, Weigent DA, Fleischmann WR Jr et al: Interferon review. Invet Radiol 22(3):259, 1987

    Article  CAS  Google Scholar 

  23. Strander H: Interferon treatment of human neoplasia. Adv Cancer Res 46:1, 1986

    Article  PubMed  CAS  Google Scholar 

  24. Welander CE: Overview of preclinical and clinical studies of interferon alfa-2b in combination with cytotoxic drugs. Invest New Drugs 5 Supp1:547, 1987.

    Google Scholar 

Download references

Authors
  1. Robert M. Friedman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Robert K. Oldham
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Oncology, Vincent T. Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington, D.C., USA

    Paul V. Woolley

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Friedman, R.M., Oldham, R.K. (1989). Antitumor Effects of Interferons. In: Woolley, P.V. (eds) Cancer Management in Man. Cancer Growth and Progression, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1095-9_2

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-1095-9_2

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6983-0

  • Online ISBN: 978-94-009-1095-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation