Abstract
Patients with malignancy frequently develop significant degrees of compromised bone marrow function and increased loss and utilization of the formed elements of the blood as a consequence of the disease process. Surgical therapy frequently results in the external loss of blood components and significant suppression of bone marrow function occurs as the result of medical therapy for the malignancy. The availability of hematologic supportive therapy in the form of transfusion of blood products has, over the past several years, in conjunction with overall improved medical support, made it possible to deliver more effective antitumor therapy and palliative support to these patients. Modern transfusion techniques and practices now provide effective temporizing measures for use during the treatment of patients with a wide variety of malignancies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abramson N, Eisenberg PD, Aster RH: Post-transfusion purpura: immunologic aspects and therapy. N Engl J Med 291:1163, 1974
Adamson J, Hilman RD: Blood volume and plasma protein replacement following acute blood loss in man. JA MA 205:63, 1968
Alavi JB, Root RK, Djerassi I, Evans AE, Gluckman SJ, MacGregor RR, Guerry D, Schreiber AD, Shaw JM, Koch P, Cooper RA: A randomized clinical trial of granulocyte transfusions for infection of acute leukemia. N Engl J Med 296:706, 1977
Barton JC: Non hemolytic, non infectious transfusion reactions. Seminars in Hematology 18:95,1981
Betzhold J, Hong R: Fatal graft-versus-host disease after a small leukocyte transfusion in a patient with lymphoma and varicella. Pediatrics 62:63, 1978.
Bishop JF, McGrath K, Wolf MM, Mathews JP, De Luise T, Holdsworth R, Yuen K, Veale M, Whiteside MG, Cooper IA, Szer J: Clinical factors influencing the efficacy of pooled platelet transfusions. Blood 71:383, 1988
Bodey GP, Buckley M, Sather YS, Freireich EJ: Quantitative relationships between circulating leukocytes and infections in patients with acute leukemia.Ann Intern Med 64:328, 1966
Butler TP, Gullino PM: Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Research 35:512, 1975
Button LN, DeWolf WC, Newburger PE, Jacobson MS, Kevy SV: The effects of irradiation on blood components. Transfusion 21:419, 1981
Cavins JA, Farber S, and Roy AJ: Transfusion of fresh platelet concentrates to adult patients with thrombocytopenia. Transfusion 8:24, 1968
Cimo PL, Aster RH: Post-transfusion purpura. N Engl J Med 287:290, 1972
Clift RA, Sanders JE, Thomas ED, Williams B, Buckner CD: Granulocyte transfusions for the prevention of infection in patients receiving bone marrow transplants. N Engl J Med 298:1052, 1978
Cohen D, Weinstein H, Mihm M, Yankee R: Nonfatal graftversus-host disease occurring after transfusion with leukocytes and platelets obtained from normal donors. Blood 53:1053, 1979
Conrad ME: Disease transmissible by blood transfusion: viral hepatitis and other infectious disorders. Seminars in Hematology 18:122, 1981
Curran JW, Lawrence DN, Jaffe H, Kaplan JE, Zyla LD, Chamberland M, Weinstein R, Lui KJ, Schonberger LB, Spira TJ, Alexander WJ, Swinger G, Ammann A, Solomon S, Auerbach D, Mildvan D, Stoneburner R, Jason JM, Haverkos HW, Evatt BL: Acquired immunodeficiency syndrome (AIDS) associated with transfusions. NEngl Med 310 69–984
Dinsmore RE, Straus DJ, Pollack MS, Woodruff JM, Garrett TJ, Young CW, Clarkson BD, Dupont B: Fatal-graft-versushost disease following blood transfusion in Hodgkin’s disease documented by HLA typing. Blood 55;831, 19XX
Djerassi I, Kim JS, Suvansi J: Filtration leukopheresis: principles and techniques of harvesting and transfusion of filtered granulocytes and monocytes. Proceedings of the International Symposium on Leukocyte Separation and Transfusions. London, England, New York, Academic Press, 1974
Duke WW: The relation of blood platelets to hemorrhagic disease: descriptive of a method for determining the bleeding time and coagulation time and report of three cases of hemorrhagic disease relieved by transfusion. JAMA 55:1185, 1910
Eys JV, Thomas D, Olivos B: Platelet use in pediatric oncology: a review of 393 transfusions. Transfusion 18:169, 1978
Feinstone SM, Kapikian AZ, Purcell RH, Alater HJ, Holland PV: Transfusion-associated hepatitis not due to viral hepatitis type A or B.N Engl J Med 292:767, 1975
Ford JM, Cullen, MH, Lucey JJ, Tobias JS, Lister TA: Fatalgraft-versus-host disease following transfusion of granulocytes from normal donors. Lancet 1167, 1976
Fortuny IE, Bloomfield CD, Hadlock DC, Goldman A, Kennedy BJ, McCullough JJ: Granulocyte transfusion: a controlled study in patients with acute nonlymphocytic leukemia. Transfusion 15:548, 1975
Freireich EJ: Effectiveness of platelet transfusion in leukemia and aplastic anemia. Transfusion 6:50, 1966
Freireich EJ, Kliman A, Gaydos LA, Mantel N, Frei E: Response to repeated platelet transfusion from the same donor. Ann Intern Med 59:277,1963
Gaydos LA, Freireich EJ, Mantel N: The quantitative relation between platelet count and hemorrhage in patients with acute leukemia.N Engl J Med 266:905, 1962
Gmur J, von Felten A, Osterwalder B, Honegger H, Hormann A, Sauter C, Deubelbeiss K, Berchtold W, Metaxas M, Scali G, Frick PG: Delayed alloimmunization using random single donor platelet transfusions: a prospective study in thrombocytopenic patients with acute leukemia. Blood 62:473, 1983
Goldfinger D: Acute hemolytic transfusion reactions - a fresh look at pathogenesis and considerations regarding therapy. Transfusion 17:85, 1977
Graw RG Jr, Herzig G, Perry S, Henderson ES: Normal granulocyte transfusion therapy of septicemia due to gram-negative bacteria. N Engl J Med 287:367, 1972
Harker LA, Slichter SH: The bleeding time as a screening test for evaluation of platelet function. N Engl J Med 287:155, 1972
Heal JM, Blumberg N, Masel D: An evaluation of cross-matching, HLA, and ABO matching for platelet transfusions to refractory patients. Blood 70:23, 1987
Heinrich D, Mueller-Eckhardt C, Stier W: The specificity of leukocyte and platelet alloantibodies in sera of patients with non-hemolytic transfusion reactions. Vox Sang 25:442, 1973
Hersh EM et al.: Causes of death in acute leukemia. JAMA 193:105, 1965
Herzig RH, Herzig GP, Bull MI, Decter JA, Lohrmann HP, Stout F, Yankee RA, Graw RG Jr: Correction of poor platelet transfusion responses with leukocyte-poor HLA-A-matched platelet concentrates. Blood 46:743, 1975
Herzig RH, Herzig GP, Graw RG Jr, Bull MI, Ray KK: Successful granulocyte transfusion therapy for gram-negative septicemia. N Engl J Med 296:701, 1977
Higby DJ, Burnett D: Granulocyte transfusions: current status. Blood 55:2, 1980
Higby DJ, Cohen E, Holland JF, Sinks L: The prophylactic treatment of thrombocytopenic leukemic patients with platelets: a double blind study. Transfusion 14:440, 1974
Higby DJ, Yates JW, Henderson ES, Holland JF: Filtration leukopheresis for granulocyte transfusion therapy. N Engl J Med 292:761, 1975
Holt PDJ, Tandy NP, Anstee DJ: Screening of blood donors for IgA deficiency: a study of the donor population of South-West England. J Clin Path 30:1007, 1977
Huestis DW: Anti-IgA in blood donors. Transfusion 16:289, 1976
Hutchin P: History of blood transfusion: a tercentennial look. Surgery 64:685, 1968
Koistinen J: Selective IgA deficiency in blood donors. Vox Sang 29:192, 1975
Lee EJ, Schiffer CA: Serial measurement of lymphocytotoxic antibody and response to nonmatched platelet transfusions in alloimmunized patients. Blood 70:1727, 1987
Liotta LA, Kleinerman J, Saidel GM: The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Research 36:889, 1976
Lohrmann HP, Bull MI, Decter JA, Yankee RA, Graw RG: Platelet transfusions from HL-A compatible unrelated donors to alloimmunized patients. Ann Intern Med 80:9, 1974
McCredie KB, Freireich EJ, Hester JP: Leukocyte transfusion therapy for patients with host-defense failure. Transplant Proc 5:1285, 1973
Meltz DJ, David DS, Bertles JF, deCiutiis AC: Delayed hemolytic transfusion reactions with renal failure. Lancet 1348, 1971
Moore SB, Taswell HF, Pinedia AA, Sonnenberg CL: Delayed hemolytic transfusion reactions. Amer Jour Clin Path 74:94, 1980
Morse EE, Freireich EJ, Carbone PP: The transfusion of leukocytes from donors with chronic myelocytic leukemia to patients with leukopenia. Transfusion 6:183, 1966
Murphy S, Koch PA, Evans AE: Randomized trial of prophylactic vs. therapeutic platelet transfusion in childhood acute leukemia. Clin Research 24:379A, 1976
Myhre BA: Fatalities from blood transfusion.JAMA 244:1333, 1980
National Institutes of Health Consensus Development Conference Statement: Perioperative Red Cell Transfusion. Vol. 7, Number 4, June 27–29, 1988
O’Donnell I, Nowicki B, Hill LR: Prevention of refractoriness using filtered blood products. Blood 71:1402, 1988
Parkman R, Mosier D, Umansky I, Cochran W, Carpenter CB, Rosen FS: Graft versus host disease after intrauterine and exchange transfusion for hemolytic disease of the newborn. N Engl J Med 290:359, 1974
Parpat AK: Whole blood preservation. J Clin Invest 26:641, 1947
Pineda AA, Brzica SM, Taswell HF Jr: Hemolytic transfusion reaction, recent experience in a large blood bank. Mayo Clin Proc 53:378, 1978
Pineda AA, Taswell HF, Brzica SM Jr: Delayed hemolytic transfusion reaction, an immunologic hazard of blood transfusion. Transfusion 18:1, 1978
Rabiner SF, Helbert JR, Lopas H, Friedman LH: Evaluation of stroma-free hemoglobin solution for use as a plasma expander. J Exp Mex 126:1127, 1967
Relihan M, Litwin MS: Effects of stroma free hemoglobin solution on clearance rate and renal function. Surgery 71:395, 1972
Rosen RC, Huestis DW, Corrigan JJ Jr: Acute leukemia and granulocyte transfusion: fatal graft-versus-host reaction following transfusion of cells obtained from normal donors. Journ Ped 93:268,1978
Roy AJ, Jaffe N, Djerassi J: Prophylactic platelet transfusions in children with acute leukemia: a dose response study. Transfusion 13:283, 1973
Schiffer CA, Aisner J, Daly PA, Schimpff SC, Wiernik PH: Alloimmunization following prophylactic granulocyte transfusion. Blood 54:766, 1979
Schmidt PJ, Holland PV: Pathogenesis of the acute renal failure associated with incompatible transfusion. Lancet 2:1169, 1967
Shulman NR, Aster RH, Leitner A et al.: Immunoreactions involving platelets. Post-transfusion purpura due to a complement-fixing antibody against genetically controlled platelet antigen: a proposed mechanism for thrombocytopenia and its relevance in “autoimmunity” J Clin Invest 40:1597, 1961
Shulman NR: Immunological considerations attending platelet transfusion. Transfusion 6:39, 1966
Slichter SJ: Controversies in platelet transfusion therapy. Ann Rev Med 31:509, 1980
Slichter SJ, Harker LA: Hemostasis in malignancy. Ann NY Acad Sci 230:252, 1974
Slichter SJ, Harker LA: Thrombocytopenia: mechanisms and management of defects in platelet production. Clinics in Haematology 7:523, 1978
Van Prooijen HC, Riemens TI, Akkerman JW: Clinical experience with transfusion of leukocyte-poor platelet concentrates prepared by filtration with prostacyclin. Blood 70:243, 1987
Vogler WR, Winton EV: A controlled study of the efficacy of granulocyte transfusions in patients with neutropenia.Am J Med 63:548, 1977
Vyas GN, Perkins HA, Yang YM, Basantani GK: Healthy blood donors with selective absence of immunoglobulin A: prevention of anaphylactic transfusion reactions caused by antibodies to IgA. J Lab Clin Med 85:838, 1975
Ward HN: Pulmonary infiltrates associated with leukoagglutinin transfusion reactions. Ann Intern Med 73:689, 1970
Weisberg JL, Linker CA: Prednisone therapy of post-transfusion purpura. Ann Intern Med 100:76, 1984
Winston DJ, Ho WG, Gale RP: Prophylactic granulocyte transfusions during chemotherapy of acute non-lymphocytic leukemia. Ann Intern Med: 94:616, 1981
Wintrobe MM, Lee GR, Boggs DR, Bithel TC, Foerster J, Athens JW, Lukens JN: Clinical Hematology Eighth Edition, Philadelphia, Lea & Febiger, 1981
Yankee RA, Grumet FC, Rogentine GN: Platelet transfusion therapy. N Engl J Med 281:1208, 1969
Yankee RA, Graff KS, Dowling R, Henderson ES: The selection of unrelated compatible platelet donors by lymphocyte HL-A matching.N Eng J Med 288:760, 1973
Zeigler Z, Murphy S, Gardner FH: Post-transfusion purpura: a heterogeneous syndrome. Blood 45:529, 1975
Zeigler ZR, Shadduck RK, Rosenfeld CS, Mangan KF, Winklestein A, Oral A, Ramsey GE, Duquesnoy RJ: High-dose intravenous gamma globulin improves responses to single-donor platelets in patients refractory to platelet transfusion. Blood 70:1433, 1987
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Kluwer Academic Publishers
About this chapter
Cite this chapter
Phares, J.C. (1989). Hematologic Support of the Patient with Malignancy. In: Woolley, P.V. (eds) Cancer Management in Man. Cancer Growth and Progression, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1095-9_17
Download citation
DOI: https://doi.org/10.1007/978-94-009-1095-9_17
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-6983-0
Online ISBN: 978-94-009-1095-9
eBook Packages: Springer Book Archive