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Organ Culture: Use in Experimental Oncology for Comparisons Among Species

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Book cover Fundamental Aspects of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 1))

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Abstract

Organ culture has been defined as “The maintenance or growth of organ primordia or the whole or parts of an organ in vitro in a way that may allow differentiation and preservation of the architecture and/or function.” (63). During the past two decades organ culture has become a valued technique in many areas of modern biology and medicine. Everything from fetal guinea pig inner ear (18) to adult mouse intestine (23) have been successfully maintained or propagated as organ cultures outside the body of the donor animal. Although organ culture has been used most extensively in recent years, its history as a valuable scientific technique goes back much farther. During a Festschrift in her honor (7), Dame Honor Fell traced the early history of organ culture to the period before the First World War. Although some work was reported in the late 1800’s, she credited the pioneering experiments of Thompson (69) and Maximow (46) and, especially between the two world wars, the Strangeways Research Laboratory at Cambridge, Pieter Gallgard’s group in the Netherlands and the French under Professor Etienne Wolff (22) with maintaining the momentum of this science.

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Authors
  1. David G. Kaufman
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  2. Gene P. Siegal
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Editors and Affiliations

  1. Pittsburgh Cancer Institute, 3343 Forbes Avenue, Pittsburgh, Pennsylvania, 15213, USA

    Ronald H. Goldfarb Ph.D.

  2. Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

    Ronald H. Goldfarb Ph.D.

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© 1989 Kluwer Academic Publishers

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Kaufman, D.G., Siegal, G.P. (1989). Organ Culture: Use in Experimental Oncology for Comparisons Among Species. In: Goldfarb, R.H. (eds) Fundamental Aspects of Cancer. Cancer Growth and Progression, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1089-8_2

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  • DOI: https://doi.org/10.1007/978-94-009-1089-8_2

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