Abstract
Kolff (1) anticipated most of the problems that have been encountered in formulating a suitable dialysis fluid for haemodialysis. After many trials he advocated a low sodium, high potassium fluid (Table 1). The major problem was the high pH of the solution and the presence of bicarbonate which affected the solubility of calcium salts. Kolff attempted to adjust pH by bubbling CO2 into the dialysis fluid. He finally used tap water containing calcium 1.0 mmol/l and gave calcium gluconate intravenously post-dialysis. To avoid haemolysis, dextrose monohydrate was added.
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References
Kolff WJ: New Ways of Treating Uraemia. London, J & A Churchill, 1947
Diem K, Lentner C (Editors): Documenta Geigy Scientific Tables 7th Edn Basle, JR Geigy, 1970, p 523
Scribner BH, Hegstrom RM, Buri R: Treatment of chronic uremia by means of hemodialysis: a progress report, in Proc 1st Int Congr Nephrol,Basel, New York, S Karger, 1961, p 616
Cole JJ, Fritzen JR, Vizzo JE, van Paasschen WH, Grimsrud L: One year’s experience with a central dialysate supply system in a hospital. Trans Am Soc Artif Intern Organs 11: 22, 1965
Mion CM, Hegstrom RM, Boen SI, Scribner BH: Substitution of sodium acetate for sodium bicarbonate in the bath fluid for hemodialysis. Trans Am Soc Artif Intern Organs 10: 110, 1964
Wolf AV, Remp DG, Kiley JE, Currie GD: Artificial kidney function: kinetics of hemodialysis. J Clin Invest 30: 1062, 1951
Parsons FM, McCracken BH: The use and function of the artificial kidney. Br J Urol 30: 463, 1958
Stewart WK, Fleming LW, Manuel MA: Benefits obtained by the use of high sodium dialysate during maintenance haemodialysis. Proc Eur Dial Transplant Assoc 9: 111, 1972
Port FK, Johnson WJ, Klass DW: Prevention of dialysis disequilibrium syndrome by use of high sodium concentration in the dialysate. Kidney Int 3: 327, 1973
Stewart WK, Fleming LW: Blood pressure control during maintenance haemodialysis with isonatric (high sodium) dialysate. Postgrad Med J 50: 260, 1974
Liebau H, Eisenbach GM, Mariss P, Hilfenhaus M: Role of sodium and water in hypertensive patients on maintenance hemodialysis. Contrib Nephrol 8: 126, 1977
Locatelli F, Costanzo R, Di Filippo S, Pedrini L, Marai P, Pozzi C, Ponti R, Sforzini S, Redaelli B: Ultrafiltration and high sodium concentration dialysis: pathophysiological correlation. Proc Eur Dial Transplant Assoc 15: 253, 1978
Stewart WK, Fleming LW, McLean S: Is hyponatric dialysis appropriate? a survey of dialysate sodium concentration in the United Kingdom. Dial Transplant 6: 9, 1977
Moriarty MV, Parsons FM: Hypernatraemia during peritoneal dialysis. Proc Eur Dial Transplant Assoc 3: 359, 1966
Nolph KD, Hopkins CA, New D, Antwiler GD, Popovich RP: Differences in solute sieving with osmotic vs. hydrostatic ultrafiltration. Trans Am Soc Artif Intern Organs 22: 618, 1976
Haruyama T, Shitomi K, Kaneda H, Takeuchi M, Murata T: Development of malignant hypertension as a result of negative sodium balance. Nippon Jinzo Gakkai Shi 19: 441, 1977
Winney RJ, Kean DM, Best JKK, Smith MA: Changes in brain water with haemodialysis. Lancet 2: 1107, 1986
Drukker W, Jungerius NA, Alberts C: Report on regular dialysis treatment in Europe III. 1967. Proc Eur Dial Transplant Assoc 4: 3, 1967
Boquin E, Parnell S, Grondin G, Wollard C, Leonard D, Michaels R, Levin NW: Crossover study of the effect of different dialysate sodium concentrations in large surface area short-term dialysis. Proc Clin Dial Transplant Forum 7: 48, 1977
Gordon A, Maxwell MH: Water, electrolyte, and acid-base disorders associated with acute and chronic dialysis, in Clinical Disorders of Fluid and Electrolyte Metabolism, 3rd edn, edited by Maxwell MH, Kleeman CR, New York, McGraw-Hill, 1980, p 827
Bergström J: Ultrafiltration without dialysis for removal of fluid and solutes in uremia. Clin Nephrol 9: 156, 1978
Wehle B, Asaba H, Castenfors J, Fürst P, Gunnarsson B, Shaldon S, Bergström J: Hemodynamic changes during sequential ultrafiltration and dialysis. Kidney Int 15: 411, 1979
Rodrigo F, Shideman J, McHugh R. Buselmeier T, Kjellstrand C: Osmolality changes during hemodialysis: natural history, clinical correlations, and influence of dialysate glucose and intravenous mannitol. Ann Intern Med 86: 554, 1977
Henrich WL, Woodard TD, Blachley JD, Gomez-Sanchez C, Pettinger W, Cronin RE: Role of osmolality in blood pressure stability after dialysis and ultrafiltration. Kidney Int 18: 480, 1980
Leski M, Niethammer T, Wyss T: Glucose-enriched dialysate and tolerance to maintenance hemodialysis. Nephron 24: 271, 1979
Arieff AI, Lazarowitz VC, Guisado R: Experimental dialysis disequilibrium syndrome: prevention with glycerol. Kidney Int 14: 270, 1978
Jenkins PG, Dreher WH: Dialysis-induced muscle cramps: treatment with hypertonic saline and theory as to etiology. Trans Am Soc Artif Intern Organs 21: 479, 1975
Kohnle W, Heimsch E, Schmidt-Wiederkehr P, Franz HE: Acid base status during treatment of chronic uremia with diafiltration. J Dial 1: 419, 1977
Henderson LW: Pre vs. post dilution hemofiltration. Clin Nephrol 11: 120, 1979
Kishimoto T, Yamagami S, Tanaka H, Ohyama T, Yamamoto T, Yamakawa M, Nishino M, Yoshimoto S, Maekawa M: Superiority of hemofiltration to hemodialysis for treatment of chronic renal failure: comparative studies between hemofiltration and hemodialysis on dialysis disequilibrium syndrome. Artif Organs 4: 86, 1980
Cambi V, Arisi L, Bignardi L, Garini G, Rossi E, Savazzi G, Migone L: Critical appraisal of hemofiltration and ultrafiltration. The development of ultra-short dialysis: preliminary results. J Dial 2: 143, 1978
Levine T, Falk B, Henriquez M, Raja RM, Kramer MS, Rosenbaum JL: Effects of varying dialysate sodium using large surface area dialyzers. Trans Am Soc Artif Intern Organs 24: 139, 1978
ManNK, PilsP, DiGuilioD, ZingraffJ, DrüekeT, JungersP, Funck-Brentano JL: Tolerance to high ultrafiltration rates during closed batch hemodialysis. Artif Organs 2: 154, 1978
Funck-Brentano JL: Ultrafiltration and diffusion techniques with the polyacrylonitrile membrane dialyzer. Proc Renal Physicians Assoc 2: 9, 1978
Schuenemann B, Borghardt J, Falda Z, Jacob I, Kramer P, Kraft B, Quellhorst E: Reactions of blood pressure and body spaces to hemofiltration treatment. Trans Am Soc Artif Intern Organs 24: 687, 1978
Cybulsky AVE, Matni A, Hollomby DJ: Effects of high sodium dialysate during maintenance hemodialysis. Nephron 41: 57, 1985
Bosch J, Ponti R, Glabman S, Lauer A: Sodium fluxes during hemodialysis. Nephron 45: 86, 1987
Eaves JA, Beare JE: The advantages of high sodium dialysate for children less than 24 kilogrammes, in Proceedings 7th British Symposium on Renal Technology, Warwick, edited by Deller A, Aldridge C, Kilvington M, Gambro, 1982, p 124
Murisasco A, France G, Leblond G, Durand C, El Mehdi M, Crevat A, Elsen R, Boobes Y, Baz M: Sequential sodium therapy allows correction of sodium-volume balance and reduces morbidity. Clin Nephrol 24: 201, 1985
Dadson IP: Conductivity and its relationship to dialysate composition. Am Assoc Nephrol Nurses Technicians J 9: 19, 1982
Ragon A, Reynier JP, Murisasco A, Elsen R, Leblond G: Dialysate sodium control during modeling in hemodialysis. Artif Organs 9: 63, 1985
Hampl H, Klopp HW, Michels N, Mahiout A, Schilling HP, Wolfgruber M, Schiller R, Hanefield F, Kessel M: Electroencephalogram investigations of the disequilibrium syndrome during bicarbonate and acetate dialysis. Proc Eur Dial Transplant Assoc 19: 351, 1982
Wilkinson R, Barber SG, Robson V: Cramps, thirst and hypertension in hemodialysis patients - the influence of dialysate sodium concentration. Clin Nephrol 7: 101, 1977
Robson M, Oren A, Ravid M: Dialysate sodium concentration, hypertension and pulmonary edema in hemodialysis patients. Dial Transplant 7: 678, 1978
Redaelli B, Sforzini S, Bondoldi G, Dadone C, Di Filippo S, Filoramo F, Limido D, Mimmo R, Pincella G, Vigano MR: Hemodialysis with ‘adequate’ sodium concentration in dialysate. Int J Artif Organs 2: 133, 1979
Locatelli F, Costanzo R, Di Filippo S: High sodium dialysate. Int J Artif Organs 2: 171, 1979
Swamy AP, Cestero RVM: Mannitol and maintenance hemodialysis. Artif Organs 3: 116, 1979
Van Stone JC, Meyer R, Murrin C, Cook J: Hemodialysis with glycerol dialysate. Trans Am Soc Artif Intern Organs 25: 354, 1979
Quellhorst EA, Schuenemann B, Mietzsch G: Long-term hemofiltration in ‘poor-risk’ patients. Trans Am Soc Artif Intern Organs 33: 758, 1987
Funck-Brentano J-L, Man NK: Optimization of Na content in dialysis fluid. Nephron 36: 197, 1984
Dumler F, Grondin G, Levin NW: Sequential high/low sodium hemodialysis: an alternative to ultrafiltration. Trans Am Soc Artif Intern Organs 25: 351, 1979
Maeda K, Saito A, Kawaguchi S, Asada A, Niwa T, Ohta K, Kobayashi K: Hemodiafiltration with sodium concentration-controlled dialysate. Artif Organs 4: 121, 1980
Chen W-T, Ing TS, Daugirdas JT, Humayun HM, Brescia DJ, Gandhi VC, Hano JE, Kheirbek AO: Hydrostatic ultrafiltration during hemodialysis using decreasing sodium dialysate. Artif Organs 4: 187, 1980
Locatelli F, Costanzo R, De Filippo S, Pedrini L, Marai P, Pozzi C, Ponti R, Sforzini S, Redaelli B: Controlled sequential ultrafiltration dialysis, iso-osmotic dialysis, isonatric dialysis: pathophysiological and clinical evaluations.Dial Transplant 8: 622, 1979
Merrill JP:The Treatment of Renal Failure. New York, Grune and Stratton Inc 1955, p 185
Oh MS, Levison SP, Carroll HJ: Content and distribution of water and electrolytes in maintenance hemodialysis. Nephron 14: 421, 1975
Butkus DE, Alfrey AC, Miller NL: Tissue potassium in chronic dialysis patients. Nephron 13: 314, 1974
Hagemann I, Schilling E, Krocker B, Precht K, Buchali K, Kruse I, Pietsch R, Eichhorst E, Seewald R: Untersuchungen des Elektrolytgehaltes in Erythrozyten im chronischen Hamodialyse-Programm bei Anwendung unterschiedlicher Spullosungen. (The electrolyte content in erythrocytes in the long-term dialysis programme during use of different irrigating solutions).Z Urol Neprhol 66: 255, 1974 (In German)
Boddy K, King PC, Lindsay RM, Briggs JD, Winchester JF, Kennedy AC: Total body potassium in non-dialysed and dialysed patients with chronic renal failure. Br Med J 1: 771, 1972
Morgan AG, Burkinshaw L, Robinson PJA, Rosen SM: Potassium balance and acid-base changes in patients undergoing regular haemodialysis therapy. Br Med J 1: 779, 1970
Cohn SH, Cinque TJ, Dombroski CS, LetteriJM: Determination of body composition by neutron activation analysis in patient with renal failure. J Lab Clin Med 79: 97, 1972
Atkinson PJ, Hancock DA, Acharya VN, Parsons FM, Proctor EA, Reed GW: Changes in skeletal mineral in patients on prolonged maintenance dialysis. Br Med J 4: 519, 1973
Maschio G, Bazzato G, Bertaglia E, Sardini D, Mioni G, D’Angelo A, Marzo A: Intracellular pH and electrolyte content of skeletal muscle in patients with chronic renal acidosis. Nephron 1: 481, 1970
Martin AM, Oduro-Dominah A, Gibbins JK, Devapal D, Mitchell DC: Regular short haemodialysis in end-stage renal failure. Br Med J 3: 758, 1975
Brynger H, Brunner FP, Chantier C, Donckerwolcke RA, Jacobs C, Kramer P, Seiwood NH, Wing AJ: Combined report on regular dialysis and transplantation in Europe, X, 1979. Proc Eur Dial Transplant Assoc 17: 4, 1980
Berlyne GM, Janabi K, Shaw AB, Hocken AG: Treatment of hyperkalaemia with a calcium-resin. Lancet 1: 169, 1966
Quintanilla AP, Wefer MI: Hyperkalemia in the patient on chronic dialysis. Int J Artif Organs 10: 17, 1987
Sandle GI, Gaiger S, Tapster S, Goodship THJ: Evidence for large intestinal control of potassium homeostasis in uraemic patients undergoing long-term haemodialysis. Clin Sci 73: 247, 1987
Edes TE, Sunderrajan EV: Heparin-induced hyperkalemia. Arch Intern Med 145: 1070, 1985
Wing AJ: Optimum calcium concentration of dialysis fluid for maintenance haemodialysis.Br Med J 4: 145, 1968
Bone JM, Davison AM, Robson JS: Role of dialysate calcium concentration in osteoporosis in patients on haemodialysis. Lancet 1: 1047, 1972
Denney JD, Sherrard DJ, Nelp WB, Chesnut CH, Baylink DJ, Murano RI, Hinn G: Total body calcium and long-term calcium balance in chronic renal disease. J Lab Clin Med 82: 226, 1973
Goldsmith RS, Furszyfer J, Johnson WJ, Beeler GW Jr, Taylor WF: Calcium flux during hemodialysis. Nephron 20: 132, 1978
Ritz E: Azotemic osteodystrophy - indications for intervention. Prog Biochem Pharmacol 17: 251, 1980
Johnson WJ: Persistent severe hypercalcemia during maintenance hemodialysis. Ann Intern Med 93: 272, 1980
Zawada ET Jr, Bennett EP, Stinson JB, Ramirez G: Serum calcium in blood pressure regulation during hemodialysis. Arch Intern Med 141: 657, 1981
Kuzela DC, Huffer WE, Conger JD, Winter SD, Hammond WS: Soft tissue calcification in chronic dialysis patients. Am J Pathol 86: 403, 1977
Zawada ET, Simmons J, Sica D: The importance of divalent ions to blood pressure regulation during hemodialysis. Int J Artif Organs 1: 245, 1984
Henrich WL, Hunt JM, Nixon JV: Increased ionized calcium and left ventricular contractility during hemodialysis. N Engl J Med 310: 19, 1984
HaddyFJ, ScottJB, EmersonTE, OverbeckHW, Daugherty RM: Effects of generalized changes in plasma electrolyte concentration and osmolarity on blood pressure in the anesthetized dog. Circ Res (Suppl) 24: I.59, 1969
Blachley JD, Blankenship DM, Menter A, Parker TF, Knöchel JP: Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 5: 237, 1985
Winney RJ, Bone JM, Anderson TJ, Robson JS: Treatment of renal osteodystrophy with 1 alpha-hydroxycholecalciferol (1 alpha-OH-D3) in conjunction with a high dialysate calcium. Calcif Tissue Res 22 (Suppl): 94, 1977
Goldsmith RS, Furszyfer J, Johnson WJ, Fournier AE, Sizemore GW, Arnaud CD: Etiology of hyperparathyroidism and bone disease during chronic hemodialysis III. Evaluation of parathyroid suppressibility. J Clin Invest 52: 173, 1973
Drüeke T, Bordier PJ, Man NK, Jungers P, Marie P: Effects of high dialysate calcium concentration on bone remodelling, serum bio-chemistry, and parathyroid hormone in patients with renal osteo-dystrophy. Kidney Int 11: 267, 1977
Bouillon R, Verberckmoes R, de Moor P: Influence of dialysate calcium concentration and vitamin D on serum parathyroid hormone during repetitive dialysis. Kidney Int 7: 422, 1975
Cundy T, Kanis JA, Earnshaw M, Woods CG: Comparative effects of alphacalcidol and parathyroidectomy with vitamin D in hyperparathyroid renal bone disease. Q J Med 60: 659, 1986
Carney SL, Gillies AHG: Effect of an optimum dialysis fluid calcium concentration on calcium mass transfer during maintenance hemodialysis. Clin Nephrol 24: 28, 1985
Massry SG: The clinical pathophysiology of magnesium: Contrib Nephrol 14: 64, 1978
Schmidt P, Kotzaurek R, Zazgornik J, Hysek H: Magnesium metabolism in patients on regular dialysis treatment. Clin Sci 41: 131, 1971
Brautbar N, Kleeman CR: Disordered divalent ion metabolism in kidney disease: comments on pathogenesis and treatment. Adv Nephrol 8: 179, 1979
Gonella M: Plasma and tissue levels of magnesium in chronically hemodialyzed patients: effects of dialysate magnesium levels. Nephron 34: 141, 1983
Heidland A, Wetzeis E: Discussion: magnesium metabolism. Contrib Nephrol 38: 203, 1984
Ahmad R: Magnesium induced neuropathy in patient undergoing haemodialysis. Br Med J 288: 1654, 1984 (unreviewed report)
Brunner FP, Thiel G: The use of magnesium-containing phosphate binders in patients with end-stage renal disease on maintenance haemodialysis [letter]. Nephron 32: 266, 1982
Drüeke T: Does Mg excess play a role in renal osteodystrophy.Contrib Nephrol 38: 195, 1984
Massry SG: Magnesium homeostasis in patients with renal failure. Contrib Nephrol 38: 175, 1984
Mandelbaum JM, Heistand ML, Schardin KE: Six months’ experience with PD-2 solution. Dial Transplant 12: 259, 1983
Johny KV, Lawrence JR, O’Halloran MW, Weilby ML: Effect of haemodialysis on erythrocyte and plasma potassium, magnesium, sodium and calcium. Nephron 8: 81, 1971
Stewart WK, Fleming LW: The effect of dialysate magnesium on plasma and erythrocyte magnesium and potassium concentrations during maintenance haemodialysis. Nephron 10: 222, 1973
Fleming LW, Lenman JAR, Stewart WK: Effect of magnesium on nerve conduction velocity during regular dialysis treatment. J Neurol Neurosurg Psychiatry 35: 342, 1972
Graf H, Kovarik J, Stummvoll HK, Wolf A: Disappearance of uraemic pruritus after lowering dialysate magnesium concentration. Br Med J 2: 1478, 1979
Burnell JM, Teubner E: Effects of decreasing dialysate magnesium in patients with chronic renal failure. Proc Clin Dial Transplant Forum 5: 191, 1976
Catto GRD, Reid IW, MacLeod M: The effect of low magnesium dialysate on plasma, ultrafiltrable, erythrocyte and bone magnesium concentrations from patients on maintenance haemodialysis. Nephron 13: 372, 1974
Alfrey AC, Miller NL: Bone magnesium pools in uraemia. J Clin Invest 52: 3019, 1973
Posner AS, Betts F, Blumenthal NC: Role of ATP and Mg in the stabilization of biological and synthetic amorphous calcium phosphates. Calcif Tissue Res 22 (Suppl): 208, 1977
Meema HE, Oreopoulos DG, Rapoport A: Serum magnesium level and arterial calcification in end-stage renal disease. Kidney Int 32: 388, 1987
Terasaki M, Rubin H: Evidence that intracellular magnesium is present in cells at a regulatory concentration for protein synthesis. Proc Nat Acad Sci USA 82: 7324, 1985
Kenny MA, Casillas E, Ahmad S: Magnesium, calcium and PTH relationships in dialysis patients after magnesium repletion. Nephron 46: 199, 1987
Freeman RM, Lawton RL: The hard-water syndrome. Med Instrum 8: 201, 1974
Drukker W: The hard water syndrome: a potential hazard during regular dialysis treatment. Proc Eur Dial Transplant Assoc 5: 284, 1968
Novello A, Kelsch RC, Easterling RE: Acetate intolerance during hemodialysis. Clin Nephrol 5: 29, 1976
Kaiser BA, Potter DE, Bryant RE, Vreman HJ, Weiner MW: Acid-base changes and acetate metabolism during routine and high-efficiency hemodialysis in children. Kidney Int 19: 70, 1981
Van Stone JC, Cook J: The effect of bicarbonate dialysate in stable chronic hemodialysis patients. Dial Transplant 8: 703, 1979
Kveim M, Nesbakken R: Utilization of exogenous acetate during hemodialysis. Trans Am Soc Artif Intern Organs 21: 138, 1975
Hakim RM, Pontzer MA, Tilton D, Lazarus JM, Gottlieb MN: Effects of acetate and bicarbonate dialysate in stable chronic dialysis patients. Kidney Int 28: 535, 1985
Mastrangelo F: Bicarbonate dialysis - pro. Int J Artif Organs 10: 145, 1987
Huyghebaert MF, Dhainaut J-F, Monsallier JF, Schlemmer B: Bicarbonate hemodialysis of patients with acute renal failure and severe sepsis. Critical Care Med 13; 840, 1985
Leunissen KML, Hoorntje SJ, Fiers HA, Dekkers WT, Mulder AW: Acetate versus bicarbonate hemodialysis in critically ill patients.Nephron 42: 146, 1986
Mastrangelo F, Rizzelli S, Corliano C, Montinaro AM, De Blasi V, Alfonso L, Aprile M, Napoli M, Laforgia R: Benefits of bicarbonate dialysis. Kidney Int 28 (Suppl 17): S188, 1985
Schilling H, Lehmann H, Hampl H: Studies on circulatory stability during bicarbonate hemodialysis with constant dialysate sodium versus acetate hemodialysis with sequential dialysate sodium. Artif Organs 9: 17, 1985
Uldall PR, Kennedy I, Craske H, Porrett E, Aid J, Woods F, Levine D: A double-blind controlled trial of acetate versus bicarbonate dialysate. Proc Clin Dial Transplant Forum 10: 220, 1980
Bijaphala S, Bell AJ, Bennett CA, Evans SM, Dawborn JK: Comparison of high and low sodium bicarbonate and acetate dialysis in stable chronic hemodialysis patients. Clin Nephrol 23: 179, 1985
Maggiore Q, Enia G, Catalano C, Polimeni RM: Bicarbonate dialysis - con. Int J Artif Organs 10: 151, 1987
Graefe U, Milutinovich J, Follette WC, Vizzo JE, Babb AL, Scribner BH: Less dialysis-induced morbidity and vascular instability with bicarbonate in dialysate. Ann Intern Med 88: 332, 1978
Hsu CH, Swartz RD, Somermeyer MG, Raj A: Bicarbonate hemodialysis: Influence on plasma refilling and hemodynamic stability. Nephron 38: 202, 1984
Leenen FHH, Buda AJ, Smith DL, Farrel S, Levine DZ, Uldall PR: Hemodynamic changes during acetate and bicarbonate dialysis. Artif Organs 8: 411, 1984
Wolff J, Pedersen T, Rossen M, Cleemann-Rasmussen K: Effects of acetate and bicarbonate dialysis on cardiac performance, transmural myocardial perfusion and acid-base balance. Int J Artif Organs 9: 105, 1986
Rorke SJ, Davidson WD, Guo SS, Morin RJ: Metabolic fate of 14C-acetate during dialysis. Proc Eur Dial Transplant Assoc 13: 394, 1976
Duarte R: Blood pressure, ventilation and lipid imbalance during hemodialysis: effect of dialysate composition. Blood Purify 199, 1985
Ksiazek A, Solski J, Sokolowska G: Sympathetic activity, plasma renin activity (PRA) and kininogen levels in patients haemodialysed with acetate and bicarbonate. Int Urol Nephrol 16: 337, 1984
Nissenson AR: Prevention of dialysis-induced hypoxemia by bicarbonate dialysis. Trans Am Soc Artif Intern Organs 26: 339, 1980
Dolan MJ, Whipp EJ, Davidson WD, Weitzman RE, Wasserman K: Hypopnea associated with acetate hemodialysis: carbon dioxide-flow-dependent ventilation. N Engl J Med 305: 72, 1981
Igarashi H, Kioi S, Gejyo F, Arakawa M: Physiologic approach to dialysis-induced hypoxemia.Nephron 41: 62, 1985
Raja R, Kramer M, Rosenbaum JL, Bollisay C, Krug M: Dialysis hypoxemia with varying dialyzers and dialysate - role of acetate in etiology. Abstracts Am Soc Artif Intern Organs 9: 60, 1980
De Backer WA, Verpooten GA, Borgonjon DJ, Vermeire PA, Lins RR, De Broe ME: Hypoxemia during hemodialysis: Effects of different membranes and dialysate compositions. Kidney Int 23: 138, 1983
Francos GC, Besarab A, Burke JF, Peters J, Tahamont MV, Gee MH, Flynn JT, Gzesh D: Dialysis-induced hypoxemia: Membrane dependent and membrane independent causes. Am J Kidney Dis 5: 191, 1985
Vaziri ND, Wilson A, Mukai D, Darwish R, Rutz A, Hyatt J, Moreno C: Dialysis hypoxemia - role of dialyser membrane and dialysate delivery system. Am J Med 11: 828, 1984
Craddock PR, Fehr J, Brigham KL, Kronenberg RS, Jacob HS: Complement and leucocyte-mediated pulmonary dysfunction in hemodialysis. N Engl J Med 296, 769, 1977
Gotch FA, Sargent JA, Keen M, Lam M, Prowitt MH: The solute kinetics of intermittent dialysis therapy. Proc 11th Annu Contractor’s Conf Artif Kidney Program of NIAMDD, Edited by Mackey BB, DHEW publ no (NIH) 79, 1442, 1978, p 110
Panzetta G, Tessitore N, Valvo E, Lupo A, Loschiavo C, Fabris A, Oldrizzi L, Gammaro L, Rugiu C, Bellotti Z, Maschio G: Biofiltration in the treatment of patients with acetate dialysis intolerance. Clin Nephrol 26: 33, 1986
Klein E, Ward RA, Harding GB: Calcium carbonate precipitation in bicarbonate hemodialysis. Artif Organs 10: 248, 1986
Keshaviah PR: Rapid dialysis therapy. Artif Organs 10: 173, 1986
Collins A, Ilstrup K, Hanson G, Berkseth R, Keshaviah P: Rapid-high-efficiency hemodialysis. Artif Organs 10: 185, 1986
Ghezzi PM, Sanz-Moreno C, Gervasio R, Migrelli S, Botella J: Technical requirements for rapid high efficiency therapy in uremic patients. Trans Am Soc Artif Intern Organs 33: 546, 1987
Manohar NL, Gorfien PC, Namba T, Louis BM, Lipner HI: Rapid improvement of uremic neuropathy on short high-efficiency hemodialysis with special reference to middle molecules. Trans Am Soc Artif Intern Organs 33: 274, 1987
Rubin JE, Berlyne GM: Long-term follow-up of patients on short-time dialysis. Trans Am Soc Artif Intern Organs 33: 540, 1987
Teschan PE: Clinical estimates of treatment adequacy. Artif Organs 10: 201, 1986
Raja RM, Kramer MS, Goldstein SJ, Mendez M, Kobrin SM: Factors affecting morbidity and mortality during long-term short dialysis. Trans Am Soc Artif Intern Organs 33: 538, 1987
Ebben JP, Hirsch DN, Luchmann DA, Collins A J, Keshaviah PR: Microbiologic contamination of liquid bicarbonate concentrate for hemodialysis. Trans Am Soc Artif Intern Organs 33: 269, 1987
Bland LA, Ridgeway MR, Aguero SM, Carson LA, Favero MS: Potential bacteriologic and endotoxin hazards associated with liquid bicarbonate concentrate. Trans Am Soc Artif Intern Organs 33: 542, 1987
von Brecht JH: Liquid bicarbonate dialysate: interdialytic and storage characteristics. Dial Transplant 14: 75, 1985
Nissenson AR, Ackerman RA, Meyers SA, Bridsall SK: Stable liquid bicarbonate hemodialysate (LBD). Dial Transplant 14: 78, 1985
Bjaeldager PAL, Christiansen E, Jensen HA, Pauley PK: Improved effect of hemodialysis on acidemic patients from an acetate concentration of 38 mmol/l. Nephron 21: 142, 1981
Wathen R, Keshaviah P, Hommeyer P, Caldwell K, Comty C: Role of dialysate glucose in preventing gluconeogenesis during hemodialysis. Trans Am Soc Artif Intern Organs 23: 393, 1977
Wathen RL, Keshaviah P, Hommeyer P, Caldwell K, Comty CM: The metabolic effects of hemodialysis with and without glucose in the dialysate.Am J Clin Nutr 31: 1870, 1978
Swamy AP, Cestero RVM, Campbell RG, Freeman RB: Long-term effect of dialysate glucose on the lipid levels of maintenance hemodialysis patients. Trans Am Soc Artif Intern Organs 22: 54, 1976
Ramirez G, Butcher DE, Morrison AD: Glucose concentration in the dialysate and lipid abnormalities in chronic hemodialysis patients. Int J Artif Organs 10: 31, 1987
Ramirez G, Bercaw BL, Butcher DE, Mathis HL, Brueggemeyer C, Newton JL: The role of glucose in hemodialysis: the effects of glucose-free dialysate.Am J Kidney Dis 7: 413, 1986
Ward RA, Shirlow MJ, Hayes JM, Chapman GV, Farrell PC: Protein-catabolism during hemodialysis. Am J Clin Nutr 32: 2443, 1979
Ward RA, Wathen RL, Williams TE, Harding GB: Hemodialysate composition and intradialytic metabolic, acid-base and potassium changes. Kidney Int 32: 129, 1987
Anonymous: Uraemic hypoglycaemia (Editorial). Lancet 1: 660, 1986
Grajower MM, Walter L, Albin J: Hypoglycemia in chronic hemodialysis patients: associated with propranolol use. Nephron 26: 126, 1980
Fassett RG, Oliver JR, Mathew TH: Hypoglycemia in end-stage renal disease. Dial Transplant 12: 543, 1983
Ganda OP, Aoki TT, Soldner JS, Morrison RS, Cahill GF Jr: Hormone-fuel concentrations in anephric subjects. J Clin Invest 57: 1403, 1976
Oreopoulos DG, Taves DR, Rabinovich S, Meema HE, Murray T, Fenton SS, de Veber GA: Fluoride and dialysis osteodystrophy: results of a double-blind study. Trans Am Soc Artif Intern Organs 20: 203, 1974
Erben J, Hajakova B, Pantucek M, Kubes L: Fluoride metabolism and renal osteodystrophy in regular dialysis treatment. Proc Eur Dial Transplant Assoc 21: 421, 1984
McIvor M, Baltazar RF, Beltram J, Mower MM, Wenk R, Lustgarten J, Solomon J: Hyperkalemia and cardiac arrest from fluoride exposure during hemodialysis. Am J Cardiol 51: 901, 1983
Parsons V, Davies C, Ogg CS, Siddiqui JY, Goode GC: The ionic composition of bone from patients with chronic renal failure and on RDT, with special reference to fluoride and aluminium.Proc Eur Dial Transplant Assoc 8: 139, 1971
Chaleil D, Simon P, Tessier B, Cartier F, Allain P: Blood plasma fluoride in haemodialysed patients. Clin Chim Acta 156: 105, 1986
Johnson WJ, Taves DR: Exposure to excessive fluoride during hemodialysis. Kidney Int 5: 451, 1974
D’Amico G, Petrella E: Standardization of hemodialysis materials. Kidney Int 28 (Suppl 7): S105, 1985
British Pharmacopoeia 1980, Addendum 1983, p 295, and Appendix XVIIIE, (6/84) pA58
Stephens D: The origin and control of rust-coloured precipitates in bicarbonate dialysate lines.Dial Transplant 15: 250, 1986
Alfrey AC: Aluminium metabolism. Kidney Int 29 (Suppl 18): S8, 1986
European Economic Community Resolution 86/C 184.04 Official J Eur Comm C184. 16 July 1986
Kolmos HJ: Hygienic problems in dialysis. Danish Med Bull 32: 338, 1985
Bommer K, Ritz E: Water quality - a neglected problem in hemodialysis. Nephron 46: 1, 1987
Shaldon S, Deschodt G, BrangerB, GranollerasC, Baldamus CA, Koch KM, Lysaght MJ, Dinarello CA: Haemodialysis hypotension: the interleukin hypothesis re-stated. Proc Eur Dial Transplant Assoc 22: 229, 1985
Schmidt M, Baldamus CA, Schoeppe W: Back filtration in hemodialysis with highly permeable membranes. Blood Purif 2: 108, 1984
Thayse C, Vanherweghem J-L, Verbanck P, Walleman P, Durieux A: Description of a central proportioning and delivery system for bicarbonate dialysis. Nephron 29: 198, 1981
Brueggemeyer CD, Ramirez G: Dialysate concentrate: A potential source for lethal complications. Nephron 46: 397, 1987
Berkes SL, Kahn SI, Chazan JA, Garella S: Prolonged hemolysis from overheated dialysate.Ann Intern Med 83: 363, 1975
Lindholm T, Thysell H, Yamamoto Y, Forsberg B, Gullberg CÅ: Temperature and vascular stability in hemodialysis. Nephron 39: 130, 1985
Mareen R, Quereda C, Lamas S, Orofono L, Teruel JL, Ortuno J: Hypoxemia and dialysate temperature. Nephron 45: 74, 1987
Von Hartitzsch B, Hoenich NA, Johnson J, Brewis RAL, Kerr DNS: The problem of de-aeration - cause, consequence, cure. Proc Eur Dial Transplant Assoc 9: 605, 1972
Drukker W, v d Werff B, Meinsma K: De-aeration of dialysis fluid. Dial Transplant 3: 33, 1974
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© 1989 Kluwer Academic Publishers
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Stewart, W.K. (1989). The Composition of Dialysis Fluid. In: Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1087-4_8
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