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Hematological Problems of Dialysis Patients

  • Chapter
Replacement of Renal Function by Dialysis

Abstract

Recently, there have been numerous significant advances in our knowledge about the pathophysiology and management of the anemia of chronic renal failure. Aluminum, which dialysis patients receive as phosphate binders, can interfere with erythropoiesis (1, 2); significant evidence has been presented to suggest that uremic inhibitors play a minor, if any, role in the causation of the anemia (3, 4); an uremic, anemic sheep model corrected the anemia with infusions of plasma-rich sheep erythropoietin (Epo) and no in vivo nor in vitro erythroid marrow inhibition could be demonstrated (5, 6); and finally, recombinant human erythropoietin (rHuEpo) has been reproduced by recombinant genetic technology methods and has been shown in clinical trials to be effective in eliminating the anemia in almost all hemodialysis patients to which it has been given (7, 8). The measurement of Epo in plasma is now easier and more reliable with the use of radioimmunoassays to either human urinary or recombinant human Epo.

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  1. Joseph W. Eschbach
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  1. Nephrology Division, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    John F. Maher M.D., FACP (Professor of Medicine, Director) (Professor of Medicine, Director)

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© 1989 Kluwer Academic Publishers

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Eschbach, J.W. (1989). Hematological Problems of Dialysis Patients. In: Maher, J.F. (eds) Replacement of Renal Function by Dialysis. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1087-4_40

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  • DOI: https://doi.org/10.1007/978-94-009-1087-4_40

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