Skip to main content
SpringerLink
Log in

Cardiovascular structure and function after treatment with calcium entry inhibitors in hypertension

  • Chapter
The Heart in Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 98))

  • 112 Accesses

Abstract

An intense research in the field of the structural cardiovascular alterations in experimental and clinical hypertension has carefully evaluated the heterogeneous nature and the clinical and physiopathological implications of either cardiac hypertrophy [1] or its vascular counterpart [2]. Thus, the importance of nonemodynamic factors in myocardial hypertrophy development, such as sympathetic stimuli [3, 4], has been elucidated even through the study of the effect of antihypertensive treatment [5, 6]. The lack of changes in myocardial mass during treatment with arteriolar vasodilators such as hydralazine or minoxidil was instrumental in developing that concept [6]. This chapter will focus on another group of vasodilators, the so called calcium entry blocker (CEB)s [7–23], rather recently brought to the front stage of antihypertensive treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tarazi RC (1986): Cardiovascular hypertrophy in hypertension. Hypertension 8(suppl II): II 187–II 190.

    CAS  Google Scholar 

  2. Folkow B (1982): Physiological aspects of primary hypertension. Physiol Rev 62: 347–504.

    PubMed  CAS  Google Scholar 

  3. Frohlich ED, Tarazi RC (1979): Is arterial pressure the sole factor responsible for hypertensive cardiac hypertrophy? Am J Cardiol 44: 956–961.

    Article  Google Scholar 

  4. Tarazi RC, Sen S, Saragoca M, Khairallah P (1982): The multifactorial role of catecholamines in hypertensive cardiac hypertrophy. Eur Heart J 3(Suppl A): 103–110.

    PubMed  CAS  Google Scholar 

  5. Tarazi RC, Fouad FM (1984): Reversal of cardiac hypertrophy in humans. Hypertension 6(suppl III): III 140–III 146.

    CAS  Google Scholar 

  6. Sen S (1983): Regression of cardiac hypertrophy: Experimental models. Am J Med 75(Suppl 3): 87a–93a.

    Article  Google Scholar 

  7. Kazda S, Garthoff B, Dycka J, Iwai J (1982): Prevention of malignant hypertension in salt loaded’ s’Dahl rats with the calcium antagonist nifedipine. Clin Exp Hyp A4: 1231–1241.

    Article  CAS  Google Scholar 

  8. Kazda S, Garthoff B, Thomas G (1982): Antihypertensive effect of calcium antagonists in rat differs from that of other vasodilators. Clinical Science 63: 363s–365s.

    Google Scholar 

  9. Motz W, Ploeger M, Ringsawandl G, Goeldel N, Garthoff B, Kazda S, Strauer BE (1983): Influence of nifedipine on ventricular function and myocardial hypertrophy in spontaneously hypertensive rats. J Cardiovasc Pharmacol 5: 55–61.

    Article  PubMed  CAS  Google Scholar 

  10. Kobayashi K, Tarazi RC (1983): Effect of nitrendipine on coronary flow and ventricular hypertrophy in hypertension. Hypertension 5(suppl II): II 45–II 51.

    CAS  Google Scholar 

  11. Kobrin I, Sesoko S, Pegram BL, Frohlich ED (1984): Reduced cardiac mass by nitrendipine is dissociated from systemic or regional haemodynamic changes in rats. Cardiovasc Res 18: 158–162.

    Article  PubMed  CAS  Google Scholar 

  12. Lundin SA, Hallback-Nordlander M (1984): Regression of structural cardiovascular changes by antihypertensive therapy in spontaneously hypertensive rats. J Hypertension 2: 11–18.

    Article  CAS  Google Scholar 

  13. Zaahringer J, Stangl E, Danninger B, Aschauer W, Motz W, Strauer B (1985): Regression of heart muscle hypertrophy after nifedipine therapy: Changes in cardiac gene expression. J Hypertension 3(Suppl 3): s493–s495.

    Google Scholar 

  14. Nyborg CB, Mulvany MJ (1985): Lack of effect of antihypertensive treatment with felodipine on cardiovascular structure of young spontaneously hypertensive rats. Cardiovasc Res 19: 528–536.

    Article  PubMed  CAS  Google Scholar 

  15. Friberg P, Folkow B, Nordlander M (1986): Cardiac dimensions in spontaneously hypertensive rats following different modes of blood pressure reduction by antihypertensive treatment. J Hypertension 4: 85–92.

    Article  CAS  Google Scholar 

  16. McLeay RAB, Stallard TJ, Watson RDS, Littler WA (1983): The effect of nifedipine on arterial pressure and reflex cardiac control. Circulation 67: 1084–1090.

    Article  PubMed  CAS  Google Scholar 

  17. Ferrara LA, De Simone G, Mancini M, Fasano ML, Pasanisi F, Vallone G (1984): Changes in left ventricular mass during a double-blind study with chlortalidone and slow-release nifedipine. Eur J Clin Pharmacol 27: 525–528.

    Article  PubMed  CAS  Google Scholar 

  18. Strauer BE, Mahmoud MA, Mayer F, Bohn I, Motz U (1984): Reversal of left ventricular hypertrophy and improvement of cardiac function in man by nifedipine. Eur Heart J 5 (sF): 53–60.

    PubMed  Google Scholar 

  19. Ferrara LA, Fasano ML, De Simone G, Goro S, Gagliardi R (1985): Antihypertensive and cardiovascular effect of nitrendipine: A controlled study vs. placebo. Clin Pharmacol Ther 38: 434–438.

    Article  PubMed  CAS  Google Scholar 

  20. Drayer JIM, Hall WD, Smith VE, Weber MA, Wollam L, White WB (1986): Effect of the calcium channel blocker nitrendipine on left ventricular mass in patients with hypertension. Clin Pharmacol Ther 40: 679–685.

    Article  PubMed  CAS  Google Scholar 

  21. Muiesan G, Agabiti-Rosei E, Romanelli G, Muiesan ML, Castellano M, Beschi M (1986): Adrenergic activity and left ventricular function during treatment of essential hypertension with calcium antagonists. Am J Cardiol 57: 44D–49D.

    Article  PubMed  CAS  Google Scholar 

  22. Amodeo C, Kobrin I, Ventura HO, Messerli FH, Frohlich ED (1986): Immediate and short term hemodynamic effects of diltiazem in patients with hypertension. Circulation 73: 108–113.

    Article  PubMed  CAS  Google Scholar 

  23. Schmieder RE, Messerli FH, Garavaglia GE, Nunez BD (1987): Cardiovascular effects of verapamil in patients with essential hypertension. Circulation 75: 1030–1036.

    Article  PubMed  CAS  Google Scholar 

  24. Fleckenstein A (1977): Specific pharmacology of calcium, cardiac pacemakers and vascular smooth muscle Ann Rev Pharmacol Toxicol 17: 149–166.

    Article  CAS  Google Scholar 

  25. Schwartz A, Triggle DJ (1984): Cellular action of calcium channel blocking drugs. Ann Rev Med 35: 325–339.

    Article  PubMed  CAS  Google Scholar 

  26. Cauvin C, Loutzenhiser R, Van Breemen C (1983): Mechanisms of calcium antagonist-induced vasodilation. Ann Rev Pharmacol Toxicol 23: 373–396.

    Article  CAS  Google Scholar 

  27. Bolton TB (1979): Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59: 606–718.

    PubMed  CAS  Google Scholar 

  28. Pedrinelli R, Tarazi RC (1984): Interference of calcium entry blockade in vivo with pressor responses to alpha-adrenergic stimulation: Effects of two unrelated blockers on responses to both exogenous and endogenously released norepinephrine. Circulation 69: 1171–1176.

    Article  PubMed  CAS  Google Scholar 

  29. Pedrinelli R, Tarazi RC (1985): Calcium entry blockade by nitrendipine and alpha-adrenergic responsiveness in vivo: comparison of systemic vs local effects. J Pharmacol Exp Ther 233: 643–649.

    PubMed  CAS  Google Scholar 

  30. Pedrinelli R, Taddei S, Salvetti A: Interference by calcium entry blockade with vasoconstrictor responses to alpha adrenergic stimulation in human beings: Effects of two unrelated blockers on forearm vascular responses to exogenous norepinephrine. Clin Pharmacol Ther 45: 285–290.

    Google Scholar 

  31. Guazzi MD, Polese A, Fiorentini C, Bartorelli A, Moruzzi P (1983): Treatment of hypertension with calcium antagonists: A review. Hypertension 5(suppl II): II 85–II 90.

    CAS  Google Scholar 

  32. Zsoter TT, Church JG (1983): Calcium antagonists: Pharmacodynamic effects and mechanisms of action. Drugs 25: 93–112.

    Article  PubMed  CAS  Google Scholar 

  33. Guazzi M, Olivati MT, Polese A, Fiorentini C, Magrini F, Moruzzi P (1977): Treatment of hypertension with nifedipine, a calcium antagonist agent. Clin Pharmacol Ther 22: 528–553.

    PubMed  CAS  Google Scholar 

  34. Stornello M, Di Rao G, Iachello M, Pisani R, Scapellato L, Pedrinelli R, Salvetti A (1983): Hemodynamic and humoral interactions between Captopril and nifedipine. Hypertension 5(suppl III): III 154–III 156.

    Google Scholar 

  35. Fouad FM, Pedrinelli R, Bravo EL, Abi-Samra F, Textor SC, Tarazi RC (1984): Clinical and systemic hemodynamic effects of nitrendipine. Clin Pharmacol Ther 35: 768–775.

    Article  PubMed  CAS  Google Scholar 

  36. Pedrinelli R, Fouad FM, Tarazi RC, Bravo EL, Textor SC (1986): Nitrendipine, a calcium entry blocker: Renal and humoral effects in human arterial hypertension. Arch Intern Med 146: 62–65.

    Article  PubMed  CAS  Google Scholar 

  37. Motz W, Strauer BE (1983): Nifedipine in the long term management of hypertensive heart disease. Hypertension 5(suppl II): II 39–II 44.

    CAS  Google Scholar 

  38. Pfeffer JM, Pfeffer MA, Flethcher P, Fishbein MC, Braunwald E (1982): Favorable effects of therapy on cardiac performance in spontaneously hypertensive rats. Am J Physiol 242: H 776–H 784.

    CAS  Google Scholar 

  39. Sano T, Tarazi RC (1987): Differential structural responses of small resistance vessels to antihypertensive therapy. Circulation 75: 618–626.

    Article  PubMed  CAS  Google Scholar 

  40. Motz W, Strauer BE (1984): Regression of structural cardiovascular changes by antihypertensive therapy. Hypertension 6(suppl III): III 133–III 139.

    CAS  Google Scholar 

  41. Freslon JL, Giudicelli JF (1983): Compared myocardial and vascular effects of Captopril and dihydralazine during hypertension development in spontaneously hypertensive rats. Br J Pharmac 80: 533–543.

    CAS  Google Scholar 

  42. Frohlich ED (1987): Cardiac hypertrophy in hypertension. New Eng J Med 317: 831–833.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Roberto Pedrinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine and Hypertension Research Center, Broussais Hospital, Paris, France

    M. E. Safar

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    F. Fouad-Tarazi

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Pedrinelli, R. (1989). Cardiovascular structure and function after treatment with calcium entry inhibitors in hypertension. In: Safar, M.E., Fouad-Tarazi, F. (eds) The Heart in Hypertension. Developments in Cardiovascular Medicine, vol 98. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0941-0_31

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0941-0_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6913-7

  • Online ISBN: 978-94-009-0941-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation