Skip to main content
SpringerLink
Log in

Left ventricular diastolic function in hypertension

  • Chapter
The Heart in Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 98))

  • 109 Accesses

Abstract

Interest in left ventricular relaxation in hypertensive patients has increased in the past decade as a result of the availability of non-invasive techniques to examine indices of cardiac function in man [1–8]. Moreover, in contrast to alterations in left ventricular passive stiffness, changes in early diastol were shown to be dependent on modifiable factors such as heart rate [8, 9, 12], adrenergic tone [2, 13], end diastolic volume [14] and intracellular calcium kinetics [15–17]. Since left ventricular relaxation and filling influence left ventricular ejection and systolic performance [18], alterations of these determinants of relaxation may change the functional capacity of the heart as well as systemic hemodynamics.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Quereshi S, Wagner HN Jr, Alerson PO, Housholder DF, Douglass KH, Lotter MG, Nickoloff EL, Tanabe M, Knowles LG (1978): Evaluation of left ventricular function in normal persons and patients with heart disease. J Nucl Med 19: 135.

    Google Scholar 

  2. Fouad FM, Tarazi RC, Gallagher JH, MacIntyre WJ, Cook SA (1980): Abnormal left ventricular relaxation in hypertensive patients. Clin Sci 59: 411s.

    Google Scholar 

  3. Inouye I, Massie B, Loge D, Topic N, Silverstein D, Simpson P, Tubau J (1985): Abnormal left ventricular filling: an early finding in mild to moderate systemic hypertension. Am J Cardiol 53: 120.

    Article  Google Scholar 

  4. Smith VE, Katz AM (1984): Relaxation abnormalities, Part II: Clinical aspects. Hosp Prac 19: 149.

    CAS  Google Scholar 

  5. Hartford M, Wikstrand J, Wallentin I, Ljungman S, Wilhelmsen L, Berglund G (1984): Diastolic function of the heart in untreated primary hypertension. Hypertension 6: 329.

    PubMed  CAS  Google Scholar 

  6. Bonow RD, Vitale DF, Bacharach SL, Frederick TM, Kent KM, Green MV (1985): Asynchronous left ventricular regional function and impaired global diastolic Ming in patients with coronary artery disease: reversal after coronary angioplasty. Circulation 71: 197.

    Article  Google Scholar 

  7. Abi-Mansour P, Fouad FM, Rincon G, Kramer JR, Tarazi RC, Loop FD (1984): Improvement of left ventricular diastolic filling following coronary bypass surgery (CBPS). Tenth European Congress of Cardiology. Dusseldorf 1984.

    Google Scholar 

  8. Fifer MA, Borow KM, Colan S, Lorell BH (1983): Left ventricular diastolic filling rate: contributions of heart rate, age, and extent of systolic shortening. Circulation 68(suppl III): III 101.

    Google Scholar 

  9. Williams LE, Loken MK, Forstrom LA, Ponto RA, Frick MP (1979): Radionuclide left-ventricular dV/dt and its dependence on cardiac rate. J Nucl Med 20: 997.

    PubMed  CAS  Google Scholar 

  10. Upton MT, Gibson DG, Brown DJ (1976): Echocardiographic assessment of abnormal left ventricular relaxation in man. Br Heart J 38: 1001–1009.

    Article  PubMed  CAS  Google Scholar 

  11. Paulsen W, Magid N, Sagar RK, Mastillo A, Wolfgang TC, Lower RR, Hess H (1985): Left ventricular function of heart allografts during acute rejection. An echocardiographic assessment. Heart Transpl 19: 525–528.

    Google Scholar 

  12. Fouad FM (1987): Left ventricular diastolic function in hypertensive patients. Circulation 75(Suppl I): 148–155.

    Google Scholar 

  13. Sonnenblick EH, Siegel JH, Sarnoff SJ (1963): Ventricular distensibility and pressure-volume curve during sympathetic stimulation. Am J Physiol 204: 1.

    PubMed  CAS  Google Scholar 

  14. Hammermeister KE, Warbassee JR (1974): The rate of change of left ventricular volume in man, II: Diastolic events in health and disease. Circulation 49: 739.

    PubMed  CAS  Google Scholar 

  15. Katz AM (1977): Physiology of the Heart, 434 pp. New York: Raven Press Books.

    Google Scholar 

  16. Katz AM (1979): Role of the contractile proteins and sarcoplasmic reticulum in the response of the heart to catecholamines: An historical review. Adv Cyclic Nucleotide Res 11: 303.

    PubMed  CAS  Google Scholar 

  17. Limas CJ, Spier SS (1980): Effect of antihypertensive therapy on calcium transport by cardiac sarcoplasmic reticulum of SHRs. Cardiovasc Res 14: 692.

    Article  PubMed  CAS  Google Scholar 

  18. Bahler RC, Martin P (1985): Effects of loading conditions and inotropic state on rapid filling phase of left ventricle. Am J Physiol 248: 523.

    Google Scholar 

  19. Udelnov MG (1968): Autoregulatory mechanism of the heart (in Russian). Nauchn Kokl Bysshei Shkoly Biol Nauki 5: 37–55.

    Google Scholar 

  20. Meerson FZ, Kapelko VI (1974): Role of the interconnection between the intensity of the contractile function and the velocity of relaxation of the cardiac muscle in the adaptation of the heart to a great load (in Russian). Kardiologiia 7: 43–53.

    Google Scholar 

  21. Meerson FZ, Kapelko VI (1975): The significance of the interrelationship between the intensity of the contractile state and the velocity of relaxation in adapting cardiac muscle to function at high work loads. J Mol Cell Cardiol 7: 793–806.

    Article  PubMed  CAS  Google Scholar 

  22. Meerson FZ (1983): The failing heart: Adaptation and deadaptation, in: Katz AM (ed). New York: Raven Press.

    Google Scholar 

  23. Fouad FM, Slominski MJ, Bravo EL, Tarazi RC (1985): Effect of calcium entry blockade on left ventricular filling in hypertension. Twelfth Interamerican Congress of Cardiology, 1985.

    Google Scholar 

  24. Walsh RA, O’Rourke RA (1985): Direct and indirect effects of calcium entry blocking agents on isovolumic left ventricular relaxation in conscious dogs. J Clin Invest 75: 1426.

    Article  PubMed  CAS  Google Scholar 

  25. Carroll JD, Hess OM, Hirzel HO, Turina M, Krayenbuehl HP (1985): Left ventricular systolic and diastolic function in coronary artery disease: Effects of revascularization on exercise-induced ischemia. Circulation 72: 119.

    Article  PubMed  CAS  Google Scholar 

  26. Templeton GH, Wildenthal K, Mitchel JH (1972): Influence of coronary blood flow on left ventricular contractility and stiffness. Am J Physiol 223: 1216.

    PubMed  CAS  Google Scholar 

  27. Brutseart DL, Rademakers FE, Sys SU (1984): Triple control of relaxation: implications in cardiac disease (Editorial). Circulation 69: 190–196.

    Article  Google Scholar 

  28. Gaasch WH, Levine HJ, Quinones MA, et al. (1976): Left ventricular compliance: Mechanisms and clinical implications. Am J Cardiol 38: 645–653.

    Article  PubMed  CAS  Google Scholar 

  29. Frohlich ED, Tarazi RC, Ulrych M, Dustan HP, Page I (1967): Tilt test for investigating a neural component in hypertension. Circulation 36: 387–393.

    PubMed  CAS  Google Scholar 

  30. Mark AL, Kerber RE (1982): Augmentation of cardiopulmonary baroreflex control of forearm vascular resistance in borderline hypertension. Hypertension 4: 39.

    PubMed  CAS  Google Scholar 

  31. Zucker IH, Gilmore JP (1981): Atrial receptor modulation of renal function in heart failure, in: Abboud FM, Fozzard HA, Gilmore JP, Reis DJ (eds), Disturbances in Neurogenic Control of the Circulation. Bethesda: American Physiological Society.

    Google Scholar 

  32. Abboud FM (1982): The sympathetic system in hypertension. State-of-the-Art Review. Hypertension 4(suppl II): II 208–II 225.

    Google Scholar 

  33. Zoller RP, Mark AL, Abboud FM, Schmid PG, Heistad DD (1972): The role of low pressure baroreceptors in reflex vasoconstrictor responses in man. J Clin Invest 51: 2967–2972.

    Article  PubMed  CAS  Google Scholar 

  34. Fouad-Tarazi FM (1987): Factors contributing to resistant hypertension. Cardiac considerations. Hypertension 11(suppl II): II 84–II 87.

    Google Scholar 

  35. Fouad FM, Tarazi RC (1986): The sympathetic drive to the heart and hypertension, in: Lown B, Malliani A, Prosdocimi M (eds), Neural Mechanisms and Cardiovascular Disease, pp 225–232. Padova (Italy): Liviana Press; Berlin-Heidelberg-New York-Tokyo: Springer Verlag (Fidia Research Series, Vol 5).

    Google Scholar 

Download references

Authors
  1. Fetnat M. Fouad-Tarazi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine and Hypertension Research Center, Broussais Hospital, Paris, France

    M. E. Safar

  2. Cleveland Clinic Foundation, Cleveland, Ohio, USA

    F. Fouad-Tarazi

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Kluwer Academic Publishers

About this chapter

Cite this chapter

Fouad-Tarazi, F.M. (1989). Left ventricular diastolic function in hypertension. In: Safar, M.E., Fouad-Tarazi, F. (eds) The Heart in Hypertension. Developments in Cardiovascular Medicine, vol 98. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0941-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-0941-0_19

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6913-7

  • Online ISBN: 978-94-009-0941-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation