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In Vivo Detection of Free Radical Metabolites

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Free Radicals in Synthesis and Biology

Part of the book series: NATO ASI Series ((ASIC,volume 260))

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Abstract

In the last two decades since the introduction of the ESR spin trapping technique the ESR study of free radical formation in vitro due to xenobiotic metabolism has been significantly enhanced. Although this ESR technique has proven useful in vitro, it has only recently been applied to drug metabolism in vivo. Spin trapping has successfully been employed to study the metabolism of halocarbons and hydrazines in perfused organs and in whole animals. The results of these current studies are detailed herein. In addition, the merits and pitfalls associated with the in vivo application of spin trapping are discussed.

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Authors and Affiliations

  1. Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences National Institutes of Health, P.O. Box 12233, Research Triangle Park, NC, 27709, USA

    Kirk R. Maples, Kathryn T. Knecht & Ronald P. Mason

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  1. Kirk R. Maples
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  2. Kathryn T. Knecht
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  3. Ronald P. Mason
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Editors and Affiliations

  1. Department of Chemistry, Politecnico di Milano, P. L. da Vinci 32, 20133, Milano, Italy

    Francesco Minisci

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© 1989 Kluwer Academic Publishers

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Maples, K.R., Knecht, K.T., Mason, R.P. (1989). In Vivo Detection of Free Radical Metabolites. In: Minisci, F. (eds) Free Radicals in Synthesis and Biology. NATO ASI Series, vol 260. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0897-0_31

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  • DOI: https://doi.org/10.1007/978-94-009-0897-0_31

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6892-5

  • Online ISBN: 978-94-009-0897-0

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