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Detection of Free Radicals in Biochemistry by Electron Spin Resonance Spectroscopy

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Free Radicals in Synthesis and Biology

Part of the book series: NATO ASI Series ((ASIC,volume 260))

Abstract

Free radical studies in biochemistry are mainly concerned with the detection and characterization of the radical species, rather than with the determination of the molecular details of the radical reaction. Two examples of electron spin resonance spectroscopy studies are described: the production of radicals from the favism-causing pyrimidine glucoside vicine, and the detection of radicals from anthracycline antitumor drugs in human blood. The results demonstrate the importance of working under conditions as close as possible to the ones found in intact biological systems.

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Author information

Authors and Affiliations

  1. Dept. of Biology, “Tor Vergata” University of Rome, Via O. Raimondo, 00173, Rome, Italy

    J. Z. Pedersen & G. Rotilio

  2. Dept. of Biochemical Sciences and CNR Center for Molecular Biology, “La Sapienza” University of Rome, Piazzale A. Moro 5, 00185, Rome, Italy

    G. Musci

Authors
  1. J. Z. Pedersen
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  2. G. Musci
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  3. G. Rotilio
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Editor information

Editors and Affiliations

  1. Department of Chemistry, Politecnico di Milano, P. L. da Vinci 32, 20133, Milano, Italy

    Francesco Minisci

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© 1989 Kluwer Academic Publishers

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Pedersen, J.Z., Musci, G., Rotilio, G. (1989). Detection of Free Radicals in Biochemistry by Electron Spin Resonance Spectroscopy. In: Minisci, F. (eds) Free Radicals in Synthesis and Biology. NATO ASI Series, vol 260. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0897-0_27

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  • DOI: https://doi.org/10.1007/978-94-009-0897-0_27

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6892-5

  • Online ISBN: 978-94-009-0897-0

  • eBook Packages: Springer Book Archive

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