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Immunosuppression

  • Chapter
Transplantation

Part of the book series: New Clinical Applications Nephrology ((NCNG,volume 9))

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Abstract

The rejection of organs transplanted between mismatched individuals of the same species (termed an allograft) represents a unique position in the repertoire of immune responses and is unlike the immune response to any other foreign antigen. The immune activity induced by an allograft represents a specific commitment of the immune system estimated at between 2–10% of the total T cell pool1. This probably occurs because the immune system is committed to the recognition of self-histocompatibility antigens (MHC) and responding to these products when they become ‘altered’ by the presence of a foreign antigen (termed MHC restriction)2. The presence as a result of a transplant of foreign MHC antigens causes confusion within the immune system, resulting in an overwhelming response. The exact nature of this immune confusion is currently the subject of much immunological research3.

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References

  1. Lindahl, K. E. and Wilson, D. B. (1977). Histocompatibility antigen-activated T lymphocytes. Estimates of the frequency and specificity of precursors. J. Exp. Med., 145, 508

    Article  PubMed  CAS  Google Scholar 

  2. Zinkernagel, R. M. and Doherty, P. C. (1974). Restriction of in vitro T cell mediated cytotoxicity in lymphocyte choriomeningitis with a syngeneic or semi allogeneic system. Nature (London), 248, 701

    Article  CAS  Google Scholar 

  3. Matzinger, P. (1981). A one receptor view of T cell behaviour. Nature (London), 292, 497

    Article  CAS  Google Scholar 

  4. Dallman, M. J. and Mason, D. W. (1982). Role of thymus derived and thymus independent cells in murine skin allograft rejection. Transplantation, 33, 221

    Article  PubMed  CAS  Google Scholar 

  5. Hamburger, J., Vagsse, J. and Crosnier, J. (1962). Renal homotransplantation in man after radiation of the recipient. Am. J. Med., 32, 854

    Article  PubMed  CAS  Google Scholar 

  6. Slavin, S., Strober, S., Fuks, Z. and Kaplon, H. S. (1976). Long term survival of skin allografts in mice treated with total lymphoid irradiations. Science, 193, 1252

    Article  PubMed  CAS  Google Scholar 

  7. Fuks, Z., Strober, S. and Bobrove, A.M. (1976). Long term effects of radiation on T and B lymphocytes in peripheral blood of patients with Hodgkin’s disease. J. Clin. Invest., 58, 803

    Article  PubMed  CAS  Google Scholar 

  8. Slavin, S., Kaplon, H. S. and Strober, S. (1976). Transplantation of allogeneic bone marrow without graft versus host disease using total lymphoid irradiation. J. Exp. Med., 147, 963

    Article  Google Scholar 

  9. Najarion, J. S., Ferguson, R. M., Sutherland, D. E. L., Slavin, S., Kim, T., Kersey, J. and Simons, R. L. (1982). Fractionated total lymphoid irradiation as preparative immunosuppression in high risk renal transplantation. Ann. Surg., 196, 442

    Article  Google Scholar 

  10. Schwartz, R. and Damashek, W. (1959). Drug induced tolerance. Nature (London), 183, 1682

    Article  CAS  Google Scholar 

  11. Calne, R. Y. (1960). The rejection of renal homografts inhibition in dogs by 6-mercaptopurine. Lancet, 1, 417

    Article  PubMed  CAS  Google Scholar 

  12. Calne, R. Y. and Murray, J. E. (1961). Inhibition of the rejection of renal homo-grafts in dogs with B20–322. Surg. Forum, 12, 118

    PubMed  CAS  Google Scholar 

  13. Murray, J. E., Merill, J. P., Harrison, J. H., Wilson, R. E. and Dammin, G. J. (1963). Prolonged survival of human kidney homografts by immunosuppressive drug therapy. N. Engl. J. Med., 268, 1315

    Article  PubMed  CAS  Google Scholar 

  14. Goodwin, W. E., Kaufman, J. J., Mimms, M. M., Turner, R. D., Glassock, K. R., Goldman, R. and Maxwell, M.M. (1963). Human renal transplantation clinical experiences with six cases of renal homotransplantation. J. Urol., 89, 13

    PubMed  CAS  Google Scholar 

  15. McGeown, M. G., Douglas, J. E., Brown, M. D., Donaldson, R. A. and Hill, C. M. (1980). Advantages of low dose steroids from the day after transplantation. Transplantation, 29, 287

    Article  PubMed  CAS  Google Scholar 

  16. Borel, J. F. (1976). Comparative study of in vitro and in vivo drug effects on cell mediated cytotoxicity. Immunology, 31, 631

    PubMed  CAS  Google Scholar 

  17. Calne, R. Y., White, D. J. G., Rolles, K., Thiru, S., Evans, D. B., McMaster, P. and Dunn, D. C. (1979). Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases and 2 livers. Lancet, 2, 1033

    Article  PubMed  CAS  Google Scholar 

  18. Multi-author (1982). European multicentre trial. Cyclosporin A as sole immunosuppressive agent in recipients of kidneys from cadaver donors. Lancet, 2, 57

    Google Scholar 

  19. Morris, P. J., French, M.F., Ting, A., Frostick, S. and Hunniset, A. (1982). A controlled trial of cyclosporin A in renal transplantation. In White, D. J. G. (ed.) Cyclosporin A, p. 355. (Amsterdam: Elsevier Biomedical)

    Google Scholar 

  20. Borel, J. F. (ed.) (1985). Cyclosporin. (Basel: Karger)

    Google Scholar 

  21. Woodruff, M. F. A. and Anderson, N. A. (1963). Effect of lymphocyte depletion by thoracic duct fistula and administration of anti-lymphocyte serum on the survival of skin homografts in rats. Nature (London), 200, 702

    Article  CAS  Google Scholar 

  22. Starzl, T. E., Marchioro, T. L., Porter, K. A., Iwasaki, Y. and Cerilli, G. J. (1967). The use of heterologous antilymphoid agents in canine renal and liver homo-transplantation and in human renal homotransplantation. Surg. Gynecol. Obstet. 301–318

    Google Scholar 

  23. Mee, A. D. and Evans, D. B. (1970). Antilymphocyte-serum preparations in treatment on renal-allograft rejection. Lancet, 2, 16

    Article  PubMed  CAS  Google Scholar 

  24. Köhler, G. and Milstein, C. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (London), 256, 495

    Article  Google Scholar 

  25. Hale, G., Bright, S., Chumbley, G. etal. (1983). Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood, 62, 873–882

    PubMed  CAS  Google Scholar 

  26. Kung, P. C., Goldstein, G., Reinherz, E. L. and Schlossman, S. F. (1979). Monoclonal antibodies defining distinctive human T cell surface antigens. Science, 206, 347–349

    Article  PubMed  CAS  Google Scholar 

  27. Tighe, H. P., Friend, P. J., Collier, St J. et al. (1988). Delayed allograft rejection in primates treated with anti-IL2 receptor monoclonal antibody Campath-6. Transplantation, 45, 226–228

    Article  PubMed  CAS  Google Scholar 

  28. Shapiro, M.E., Kirkman, R. L., Reed, M.H. etal. (1987). Monoclonal anti-IL2 receptor antibody in primate renal transplantation. Transplant. Proc., 19, 594–598

    PubMed  CAS  Google Scholar 

  29. Soulillou, J. P., Le Mauff, B., Olive, D. et al. (1987). Prevention of rejection of kidney transplants by monoclonal antibody directed against interleukin-2 Lancet, 2, 1339–1342

    Article  Google Scholar 

  30. Ortho Multicenter Transplant Study Group (1985). A randomized clinical trial of OKT3 monoclonal antibody for acute rejection of cadaveric renal transplants N. Engl. J. Med., 313, 337–342

    Article  Google Scholar 

  31. Debure, A., Chkoff, N., Chatenoud, L. et al. (1988). One month prophylactic use of OKT3 in cadaver kidney transplant recipients. Transplantation, 45, 546–553

    Article  PubMed  CAS  Google Scholar 

  32. Friend, P. J., Calne, R. Y., Hale, G., Waldmann, H. et al. (1987). Prophylactic use of an antilymphocyte monoclonal antibody following renal transplantation — a randomised controlled trial. Transplant. Proc., 19, 1898–1900

    PubMed  CAS  Google Scholar 

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Authors
  1. D. J. G. White
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  2. P. Friend
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  3. R. Y. Calne
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Editor information

Editors and Affiliations

  1. University of Aberdeen, UK

    G. R. D. Catto MD, DSc, FRCP (Lond., Edin. and Glas.) (Professor of Medicine and Therapeutics) (Professor of Medicine and Therapeutics)

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© 1989 Kluwer Academic Publishers

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White, D.J.G., Friend, P., Calne, R.Y. (1989). Immunosuppression. In: Catto, G.R.D. (eds) Transplantation. New Clinical Applications Nephrology, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0855-0_5

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  • DOI: https://doi.org/10.1007/978-94-009-0855-0_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6872-7

  • Online ISBN: 978-94-009-0855-0

  • eBook Packages: Springer Book Archive

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