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Amish study of genetics of affective disorders

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Abstract

This paper will review the epidemiologic and genetic studies of major affective disorders among the Old Order Amish of Pennsylvania. The Amish Study has been funded for a 14 year period (1976–1990) by the National Institute of Mental Health. It was designed and directed by J.A. Egeland, who began a series of a studies on the Amish in 1959 and has developed close ties to the community over time. The academic base of the study has been the Department of Psychiatry of the School of Medicine, University of Miami, Florida. The work has fostered an interface between psychiatry, epidemiology, human genetics and molecular biology. There has been collaboration with eleven schools of medicine and a number of laboratories providing the research teams needed to address different clinical and genetic studies.

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Reference

  1. Egeland, JA and Hostetter, AM (1983). Amish study: I. Affective disorders among the Amish, 1976–1980. Am. J. Psychiatry 140: 56–61.

    PubMed  CAS  Google Scholar 

  2. Egeland, JA (1986). Cultural factors and social stigma for manic-depression: The Amish Study. Am. J. Soc. Psychiatry 6: 279–286.

    Google Scholar 

  3. Egeland, JA (1983). Bipolarity: The iceberg of affective disorders? Comp. Psychiatry 24: 4, 377–344.

    Article  Google Scholar 

  4. Egeland, JA and Sussex, JN (1985) Suicide and family loading for affective disorders. J. Am. Med. Assoc. 254: 915–918.

    Article  CAS  Google Scholar 

  5. Hostetter, AM, Egeland, JA and Endicott, J (1983). Amish Study: II. Concensus diagnoses and reliability results. Am. J. Psychiatry 140: 62–66.

    PubMed  CAS  Google Scholar 

  6. Kidd, KK, Egeland, JA, Molthan, L, Pauls, DL, Kruger, SD and Messner, KH (1984). Am. J. Psychiatry 141: 1042–1048.

    PubMed  CAS  Google Scholar 

  7. Gershon, ES, Targum, SD, Matthysse, S and Bunney, WE (1979). Colorblindness not closed linked to bipolar illness. Arch. Gen. Psychiatry 36: 1423–1430.

    PubMed  CAS  Google Scholar 

  8. Baron, M, Risch, N, Hamburger, R, Mandel, B, Kushner, S, Newman, M, Drumer, D and Belmaker, RH (1987). Genetic linkage between X-chromosome markers and bipolar affective illness. Nature 326: 289–292.

    Article  PubMed  CAS  Google Scholar 

  9. Goldin, LR, Clerget-Darpoux, F and Gershon, ES (1982). Relationship of HLA to major affective disorder not supported. J. Psychiatry Res. 7: 29–45.

    Article  CAS  Google Scholar 

  10. Pauls, DL and Egeland, JA (1988). Autosomal dominant inheritance of bipolar affective disorders: Segregation analyses of Old Order Amish families. (Submitted for publication)

    Google Scholar 

  11. Egeland, JA. Amish major affective disorders pedigrees, in 1985 and 1986/1987 Catalog of Cell Lines NIGMS Human Genetic Mutant Cell Repository. (eds.) NIH Publications 85–2011 and 87–2011. Washington, DC. US Department of Health and Human Services, 1985, pp 560–567, 1986/1987, pp. 298–306 and 489–496.

    Google Scholar 

  12. Kidd, JR, Egeland, JA, Pakstis, AJ, Castiglione, CM, Pletcher, BA, Morton, LA and Kidd, KK (1987). Searching for a major genetic locus for affective disorder in the Old Order Amish. J. Psychiat. Res. 21: 577–580.

    Article  CAS  Google Scholar 

  13. Gerhard, DS, Egeland, JA, Pauls, DL, Kidd, JR, Kramer, PL, Housman, DE and Kidd, KK (1984). Is a gene for affective disorder located on the short arm of chromosome 11? Am. J. Hum. Genet. 36: 3S.

    Google Scholar 

  14. Egeland, JA, Gerhard, DS, Pauls, DL, Sussex, JN, Kidd, KK, Allen, CR, Hostetter, AM and Housman, DE. (1987). Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325: 783–787.

    Article  PubMed  Google Scholar 

  15. Gerhard, DS, Egeland, JA, Pauls, DL and Housman, DE (1987) Search for a gene that predisposes individuals to BPI disorder. J. Psychiat. Res. 21: 569–575.

    Article  PubMed  CAS  Google Scholar 

  16. Gershon, ES, Merril, CR, Goldin LR, DeLisi, LE, Berrettini, WH and Nurnberger, JI (1987). The role of molecular genetics in psychiatry. Biol. Psychiatry 22: 1388–1405.

    Article  PubMed  CAS  Google Scholar 

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© 1990 Kluwer Academic Publishers

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Egeland, J.A. (1990). Amish study of genetics of affective disorders. In: Cazzullo, C.L., Sacchetti, E., Conte, G., Invernizzi, G., Vita, A. (eds) Plasticity and Morphology of the Central Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0851-2_15

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  • DOI: https://doi.org/10.1007/978-94-009-0851-2_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6870-3

  • Online ISBN: 978-94-009-0851-2

  • eBook Packages: Springer Book Archive

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